Table 2 Effects of donepezil on Aβ_25-35-induced cell viability and LDH release (n = 6, mean ± SD)

Control

100

100

Aβ_25-35

57.35 ± 3.95^*

164.57 ± 14.52^*

Aβ_25-35 + 1 μmol donepezil

71.83 ± 6.01

152.63 ± 11.35

Aβ_25-35 + 5 μmol donepezil

79.61 ± 7.72^**

129.26 ± 11.56^**

Aβ_25-35 + 10 μmol donepezil

86.37 ± 7.45^**

124.21 ± 7.44^**

Aβ_25-35 + 20 μmol donepezil

88.98 ± 9.36^**

129.66 ± 5.27^**

Aβ_25-35 + 50 μmol donepezil

87.35 ± 7.42^**

138.25 ± 5.93^**

P

0.004

0.000