Table 2 Gene Ontology enrichment analysis of common DEGs among COVID-19, SS, and NASH

GO Biological Process

GO:0,045,893

Positive regulation of transcription, DNA-templated

1.06E−08

NFE2;CSF3;JUN;TGFB3;SLC11A1;LIF;FOS;NFKB2;IL6;NR4A3;IL1B;ZC3H12A;BCL3r;MAFF;HIVEP1;NCOA7;ATF3;CREB5

GO:0,071,345

Cellular response to cytokine stimulus

2.42E−08

SOCS3;CSF3;IL6;SOCS1;CCL20;IL1B;ZC3H12A;LIF;HAS2;IRAK3;FOS;PTGS2

GO:0,006,954

Inflammatory response

3.59E−08

IL6;TNFAIP6;CCL20;SLC11A1;IL1B;C5AR1;PROK2;PTX3;FOS

GO:0,019,221

Cytokine-mediated signaling pathway

3.77E−07

SOCS3;CSF3;IL6;SOCS1;CCL20;IL1B;LIF;MAP3K8;IRAK3;FOS;PTGS2;IFIT2

GO:0,045,944

Positive regulation of transcription by RNA polymerase II

5.43E−07

CSF3;JUN;TGFB3;SLC11A1;LIF;FOS;NFKB2;IL6;NR4A3;ZC3H12A;MAFF;HIVEP1;NCOA7;ATF3

GO:0,008,284

Positive regulation of cell population proliferation

1.81E−06

CSF3;IL6;NR4A3;TGFB3;IL1B;C5AR1;LIF;PROK2;HAS2;HBEGF

GO:1,904,893

Negative regulation of receptor signaling pathway via STAT

4.60E−06

SOCS3;SOCS1;BCL3

GO:0,070,555

Response to interleukin-1

6.97E−06

CCL20;IL1B;ZC3H12A;HAS2;IRAK3

GO:0,071,347

Cellular response to interleukin-1

8.45E−06

CCL20;IL1B;ZC3H12A;HAS2;MAP3K8;IRAK3

GO:0,032,496

Response to lipopolysaccharide

9.78E−06

CD274;IL6;SLC11A1;IL1B;ZC3H12A;IRAK3

GO Cellular Component

GO:0,005,634

Nucleus

1.17E−03

ZC3H12A;HIVEP1;ANXA9;IER3;KLF11;NFE2;JUN;PRRX1;GADD45B;IRAK3;SERPINB9;FOS;KIF22;PNRC1;NFKB2;MT1A;NR4A3;BCL3;MAFF;NCOA7;S100P;PADI4;ATF3;APOBEC3A;CREB5

GO:0,043,231

Intracellular membrane-bound organelle

4.42E−03

ZC3H12A;HIVEP1;ANXA9;IER3;KLF11;NFE2;JUN;PRRX1;GADD45B;TGFB3;IRAK3;SERPINB9;FOS;KIF22;PNRC1;NFKB2;MT1A;NR4A3;BCL3;MAFF;NCOA7;S100P;PADI4;ATF3;APOBEC3A;CREB5

GO:0,030,667

Secretory granule membrane

1.03E−02

RAB26;SLC11A1;C5AR1;PLAUR

GO:1,904,724

Tertiary granule lumen

1.26E−02

TNFAIP6;PTX3

GO:0,070,820

Tertiary granule

1.44E−02

TNFAIP6;SLC11A1;PTX3

GO:0,042,406

Extrinsic component of endoplasmic reticulum membrane

2.45E−02

ZC3H12A

GO:0,000,932

P-body

2.56E−02

ZC3H12A;APOBEC3A

GO:0,005,859

Muscle myosin complex

4.55E−02

MYH11

GO:0,070,013

Intracellular organelle lumen

4.70E−02

IL6;TNFAIP6;SDC4;PLAUR;PTX3;PTGS2

GO:0,005,640

Nuclear outer membrane

4.85E−02

PTGS2

GO Molecular Function

GO:0,035,497

cAMP response element binding

3.35E−06

JUN;NR4A3;CREB5

GO:0,005,125

Cytokine activity

1.58E−05

CSF3;IL6;TGFB3;CCL20;IL1B;LIF

GO:0,003,690

Double-stranded DNA binding

2.91E−05

KLF11;NFE2;JUN;MAFF;HIVEP1;FOS;BACH2;ATF3;CREB5;NFKB2

GO:0,043,565

Sequence-specific DNA binding

5.83E−05

KLF11;NFE2;JUN;MAFF;HIVEP1;FOS;BACH2;ATF3;CREB5;NFKB2

GO:1,990,837

Sequence-specific double-stranded DNA binding

6.19E−05

KLF11;NFE2;JUN;MAFF;HIVEP1;FOS;BACH2;ATF3;CREB5;NFKB2

GO:0,008,083

Growth factor activity

1.54E−04

CSF3;IL6;LIF;HBEGF

GO:0,000,978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1.82E−04

KLF11;NFE2;JUN;NR4A3;PRRX1;MAFF;HIVEP1;FOS;BACH2;ATF3;CREB5;NFKB2

GO:0,000,987

Cis-regulatory region sequence-specific DNA binding

1.82E−04

KLF11;NFE2;JUN;NR4A3;PRRX1;MAFF;HIVEP1;FOS;BACH2;ATF3;CREB5;NFKB2

GO:0,005,126

Cytokine receptor binding

3.17E−04

CSF3;IL6;IL1B;LIF

GO:0,070,851

Growth factor receptor binding

3.17E−04

CSF3;IL6;IL1B;HBEGF