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Table 3 Pathway enrichment analysis of common DEGs among COVID-19, SS, and NASH

From: Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Category

Pathways

P - values

Genes

WikiPathway 2021 Human

IL-18 signaling pathway WP4754

8.60E−14

JUN;SDC4;CCL20;RGS16;FOS;PTGS2;NFKB2;SOCS3;IL6;IL1B;ZC3H12A;PTX3;ATF3;IER3

 

Glucocorticoid receptor pathway WP2880

2.00E−09

JUN;GADD45B;CCL20;SERPINB9;S100P;PTGS2;NFKB2

 

Regulation of toll-like receptor signaling pathway WP1449

1.10E−08

JUN;IL6;SOCS1;IL1B;MAP3K8;IRAK3;FOS;NFKB2

 

Nuclear receptors meta-pathway WP2882

4.78E−08

JUN;GADD45B;CCL20;IL1B;MAFF;SERPINB9;S100P;PTGS2;HBEGF;NFKB2

 

Signal transduction through IL1R WP4496

5.39E−08

JUN;IL6;TGFB3;IL1B;IRAK3

 

Photodynamic therapy-induced NF-kB survival signaling WP3617

7.34E−08

IL6;BCL2A1;IL1B;PTGS2;NFKB2

 

Hypertrophy Model WP516

3.91E−07

NR4A3;CYR61;ATF3;HBEGF

 

Photodynamic therapy-induced AP-1 survival signaling. WP3611

4.62E−07

JUN;IL6;BCL3;FOS;HBEGF

 

Myometrial relaxation and contraction pathways WP289

5.27E−07

JUN;IL6;IL1B;RGS16;MAFF;FOS;ATF3

 

Hematopoietic stem cell differentiation WP2849

7.50E−07

NFE2;CSF3;IL6;IL1B;FOS

BioCarta 2016

Signal transduction through IL1R Homo sapiens h il1rPathway

1.25E−09

JUN;IL6;TGFB3;IL1B;IRAK3;FOS

 

Oxidative Stress induced gene expression Via Nrf2 Homo sapiens h arenrf2Pathway

2.24E−05

JUN;MAFF;FOS

 

TSP-1 Induced apoptosis in microvascular endothelial cell Homo sapiens h tsp1Pathway

1.97E−04

JUN;FOS

 

Pertussis toxin-insensitive CCR5 signaling in macrophage Homo sapiens h Ccr5Pathway

3.36E−04

JUN;FOS

 

IL-2 receptor beta chain in T cell activation Homo sapiens h il2rbPathway

4.72E−04

SOCS3;SOCS1;FOS

 

MAPKinase signaling pathway Homo sapiens h mapkPathway

6.99E−04

JUN;MAP3K8;FOS

 

Calcium signaling by HBx of Hepatitis B virus Homo sapiens h HBxPathway

9.67E−04

JUN;FOS

 

Repression of pain sensation by the Transcriptional Regulator DREAM Homo sapiens h dreampathway

9.67E−04

JUN;FOS

 

Cadmium induces DNA synthesis and proliferation in macrophages Homo sapiens h cdMacPathway

0.001103311

JUN;FOS

 

Nerve growth factor pathway (NGF) Homo sapiens h ngfPathway

0.001247926

JUN;FOS

Reactome 2016

MyD88:Mal cascade initiated on plasma membrane Homo sapiens R-HSA-166058

4.01E−07

JUN;SOCS1;MAP3K8;IRAK3;FOS;NFKB2

 

Toll like receptor TLR1:TLR2 cascade Homo sapiens R-HSA-168179

4.01E−07

JUN;SOCS1;MAP3K8;IRAK3;FOS;NFKB2

 

Toll like receptor TLR6:TLR2 cascade Homo sapiens R-HSA-168188

4.01E−07

JUN;SOCS1;MAP3K8;IRAK3;FOS;NFKB2

 

Toll like receptor 2 (TLR2) cascade Homo sapiens R-HSA-181438

4.01E−07

JUN;SOCS1;MAP3K8;IRAK3;FOS;NFKB2

 

Immune System Homo sapiens R-HSA-168256

6.13E−07

CD274;CSF3;JUN;SLC11A1;C5AR1;LIF;IRAK3;FOS;KIF22;IFIT2;NFKB2;SOCS3;IL6;SOCS1;IL1B;MAP3K8;IER3;HBEGF

 

Activated TLR4 signaling Homo sapiens R-HSA-166054

1.28E−06

JUN;SOCS1;MAP3K8;IRAK3;FOS;NFKB2

 

Toll Like Receptor 4 (TLR4) cascade Homo sapiens R-HSA-166016

2.12E−06

JUN;SOCS1;MAP3K8;IRAK3;FOS;NFKB2

 

Cytokine Signaling in Immune system Homo sapiens R-HSA-1280215

2.81E−06

SOCS3;CSF3;IL6;SOCS1;IL1B;LIF;MAP3K8;IRAK3;IFIT2;HBEGF;NFKB2

 

Signaling by interleukins Homo sapiens R-HSA-449147

3.16E−06

SOCS3;CSF3;IL6;IL1B;LIF;MAP3K8;IRAK3;HBEGF;NFKB2

 

Toll-like receptors cascades Homo sapiens R-HSA-168898

4.71E−06

JUN;SOCS1;MAP3K8;IRAK3;FOS;NFKB2

KEGG 2021 Human

TNF signaling pathway

4.11E−14

SOCS3;JUN;IL6;CCL20;IL1B;BCL3;LIF;MAP3K8;FOS;PTGS2;CREB5

 

IL-17 signaling pathway

1.61E−08

CSF3;JUN;IL6;CCL20;IL1B;FOS;PTGS2

 

Rheumatoid arthritis

4.28E−07

JUN;IL6;TGFB3;CCL20;IL1B;FOS

 

C-type lectin receptor signaling pathway

8.30E−07

JUN;IL6;IL1B;BCL3;PTGS2;NFKB2

 

Osteoclast differentiation

2.68E−06

SOCS3;JUN;SOCS1;IL1B;FOS;NFKB2

 

Leishmaniasis

4.04E−06

JUN;TGFB3;IL1B;FOS;PTGS2

 

Coronavirus disease

7.38E−06

CSF3;JUN;IL6;IL1B;C5AR1;FOS;HBEGF

 

Chagas disease

1.61E−05

JUN;IL6;TGFB3;IL1B;FOS

 

Malaria

1.73E−05

CSF3;IL6;TGFB3;IL1B

 

Toll like receptor signaling pathway

1.76E−05

JUN;IL6;IL1B;MAP3K8;FOS

  1. Only the top ten pathways for each category were shown. DEGs, DEGs, differential expression genes; COVID-19, coronavirus disease-2019; SS, simple steatosis; NASH, non-alcoholic steatohepatitis; KEGG, Human Kyoto Encyclopedia of Genes and Genomes