Systems biology approach reveals a common molecular basis for COVID-19 and non-alcoholic fatty liver disease (NAFLD)

Table 4 Potential drugs targeting common DEGs among COVID-19, SS, and NASH

Name	P - values	Molecular formula	Molecular weight	Structure formula
Digoxin HL60 UP	2.20E−24	C₄₁H₆₄O₁₄	780.9
8-Azaguanine PC3 UP	1.24E−22	C₄H₄N₆O	152.11
Ciclopirox HL60 UP	3.00E−21	C₁₂H₁₇NO₂	207.27
Ouabain HL60 UP	3.52E−21	C₂₉H₄₄O₁₂	584.7
Etoposide HL60 UP	6.43E−21	C₂₉H₃₂O₁₃	588.6
Menadione HL60 UP	7.85E−21	C₁₁H₈O₂	172.18
Cephaeline HL60 UP	1.03E−19	C₂₈H₃₈N₂O₄	466.6
ZINC CTD	5.39E−19	Zn	65.4	Zn
Cicloheximide PC3 UP	2.33E−18	C₁₅H₂₃NO₄	281.35
Pyrvinium HL60 UP	5.58E−18	C₂₆H₂₈N₃⁺	382.5

The top ten drugs are shown. DEGs, DEGs, differential expression genes; COVID-19, coronavirus disease-2019; SS, simple steatosis; NASH, non-alcoholic steatohepatitis