Fig. 5

circ_0023404 promotes migration and invasion of endometrial cancers through by miR-217/MARK1 axis. Ishikawa cell co-transfected with si-circ_0023404, anti-miR-217 with si-MARK1 for 48 h and subjected to Transwell migration and invasion assay (A). The statistics of Transwell migration (B) and invasion (C) assay were analyzed. (D): schematic diagram of proposed mechanism for circ_0023404-miR-217 MARK1 axis in EC progression. circ_0023404 sponges and inhibits miR-217 which negatively regulates MAPK1 mRNA expression, subsequently leads to increased MAPK1 protein and promotes EC progression