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Table 1 Demographic and clinical data of subjects enrolled in studies evaluating levels of Hcy, FIB and LPa in patients With PAD and control subjects

From: Relationship between serum homocysteine, fibrinogen, lipoprotein-a level, and peripheral arterial disease: a dose–response meta-analysis

No.

Authors

Years

Study design

Country

Number of participants

Men n(%)

Age

Exposure

OR

SMD/WMD

PAD

Controls

PAD

Controls

PAD

Controls

mean

SD

mean

SD

1

Thomas Mueller [39]

2005

Case–control study

Austria

433

433

306 (70.7)

306 (70.7)

68

11.85

68

11.11

Hcy

 

2

Mengyuan Liu [36]

2020

Cohort study

China

3119

NG

NG

NG

NG

NG

NG

NG

Hcy

 

3

Dan Rong [37]

2017

Case–control study

China

240

240

203 (84.6)

195 (80.0)

63.6

12

59.2

7.8

Hcy

4

Janaka Weragoda [40]

2016

Case–control study

Sri Lanka

79

158

NG

NG

NG

NG

NG

NG

Hcy

 

5

Monica L. Bertoia [41]

2014

Cohort study

Netherlands

Women: 143

Men: 143

424

428

NG

NG

59.9

65.4

5.2

8.1

60

65.3

5.2

8.1

Hcy

  

6

Tamam Mohamad [42]

2011

Cohort study

US

6590

NG

NG

NG

NG

NG

NG

NG

Hcy

 

7

Michelangelo Sartori [21]

2010

Cross-sectional study

Italy

CL: 181

CLI:110

210

118 (65.2)

69 (72.7)

122 (67.4)

68.7

72.2

9.4

9.4

68.6

5.8

FIB

 

8

Adriano Sabino [43]

2009

Case–control study

Brazil

44

37

26(59.1)

17 (45.9)

68.9

9.7

60.9

9.2

Hcy

 

9

L. Garofolo [44]

2007

Cross-sectional study

Brazil

1008

NG

NG

NG

NG

NG

NG

NG

Hcy

 

10

Eliseo Guallar [45]

2005

Cross-sectional study

US

310

4137

139 (44.8)

2011 (48.6)

68.5

10.2

55.5

3.4

Hcy

  

11

Matthew A. Allison [46]

2006

Cross-sectional study

US

275

6378

126 (45.8)

2981 (46.7)

70

9

62

10

FIB + Hcy

 

12

P. Eller [20]

2005

Cross-sectional study

Austria

241

241

164 (68.0)

164 (68.0)

68.6

11.8

69.3

11.4

Hcy

 

13

T. Mueller [47]

2004

Case–control study

Austria

100

100

47 (47)

47 (47)

76

7.4

76

8.1

Hcy

 

14

Maurice A. A. J. van den Bosch [48]

2003

Case–control study

Netherlands

220

629

0

0

48

7

44.8

8.3

Hcy

15

DG.M. Bloemenkamp [49]

2002

Case–control study

Netherlands

212

475

0

0

48.2

7

45.5

8.1

Hcy

 

16

D. G. M. Bloemenkamp [50]

2002

Case–control study

Netherlands

150

412

0

0

48.7

6.9

45.5

7.9

Hcy

 

17

H. Stricker [51]

2001

Case–control study

Switzerland

51

51

32 (62.7)

32 (62.7)

68.3

NG

68.5

NG

Hcy

18

Robert Loncar [52]

2001

Case–control study

Germany

40

40

NG

NG

51.8

7.5

45.6

6.8

Hcy

 

19

Daniel Bunout [53]

2000

Case–control study

Chile

32

24

NG

NG

69.6

11

71.8

9.9

Hcy

 

20

L. Todesco [54]

1999

Case–control study

Switzerland

63

106

29 (46.0)

58 (54.7)

74

10

76

16

Hcy

 

21

Wibert S. Aronow [55]

1998

Cross-sectional study

US

men: 51

women: 96

107

266

NG

NG

82

84

9

8

80

81

8

8

Hcy

 

22

M.R. Malinow [56]

1989

Case–control study

US

47

29

26 (55.3)

18 (62.1)

70.1

10.6

65.9

3.9

Hcy

 

23

Lloyd M. Taylor [57]

1991

Case–control study

US

214

29

110 (51.4)

18 (62.1)

65

11.5

66

3.9

Hcy

 

24

Aeron M. Small [13]

2020

Cohort study

US

24,009

5373

1925

150,983

42,485

18,285

23,416 (97.5%)

5166 (96.1%)

1885 (97.9%)

138,753 (91.9%)

36,188 (85.2%)

16,400 (89.7%)

74.4

69.6

71.6

9.4

9.4

9.6

66.9

60.4

59.0

13.2

11.6

14.8

FIB

 

25

Savas Celebi [58]

2020

Cross-sectional study

Turkey

152

128

126 (82.90)

86 (67.18)

69.01

11.13

58.13

12.78

FIB

 

26

Alexandr Ceasovschih [22]

2020

Case–control study

Romania

216

80

176 (81.5)

64 (80)

69

15

68

16

FIB

 

27

C. Roncal Mancho [59]

2014

Case–control study

Spain

88

20

NG

NG

71

11

80

5

FIB

 

28

S. Marlene [60]

2014

Cohort study

US

113

727

113 (100)

727 (100)

68

10

67

11

FIB

 

29

Anetta Undas [61]

2010

Case–control study

Poland

106

106

82 (77.4)

79 (74.5)

57.1

6.9

56.4

6.8

FIB + Hcy

 

30

Emile L.E. de Bruijne [62]

2010

Case–control study

Netherlands

47

141

13 (27.7)

39 (27.7)

43.2

7.9

43

7.6

FIB

 

31

Laura M Reich [63]

2007

Cohort study

US

441

13,939

159 (36)

6273 (45)

57

7.4

54

7.4

FIB

 

32

Roberto Antonio Mangiafico [64]

2006

Case–control study

Italy

164

164

122 (74)

120 (73)

70

3.4

70.3

3.7

FIB

 

33

E.A. Kaperonis [65]

2006

Case–control study

Greece

51

30

43 (84.3)

21 (70)

70

7.3

67

13.6

FIB

 

34

Rachel P. Wildman [66]

2005

Cohort study

US

4787

NG

NG

NG

NG

NG

NG

NG

FIB

 

35

Khurram Nasir [67]

2005

Cross-sectional study

US

220

3729

72 (36)

1790 (48)

68

16.3

54

12.2

FIB

 

36

Elizabeth Selvin [6]

2004

Cross-sectional study

US

141

2033

65 (46.2)

980 (48.2)

68.7

1.5

55.7

0.4

FIB

 

37

A. Kursat Bozkurt [68]

2004

Case–control study

Turkey

20

20

20 (100)

20 (100)

58.5

8.5

49.6

9.2

FIB

 

38

Felicity B. Smith [69]

2003

Cross-sectional study

UK

104

663

56 (53.9)

317 (47.8)

65.8

5.1

63.7

5.1

FIB

 

39

Andrew J. Makin [70]

2003

Case–control study

UK

234

50

145 (62)

27 (54)

68.6

10

68.6

10

FIB

 

40

R. Giunta [71]

2001

Case–control study

Italy

27

20

15 (55.6)

11 (55.0)

66

11

65

10

FIB

 

41

Wouter T. Meijer [14]

2000

Cohort study

Netherlands

men:2589

women:3861

NG

NG

NG

NG

NG

NG

NG

FIB + Hcy

 

42

Andrew Blann [72]

1998

Cross sectional study

UK

95

120

75 (79)

84 (70)

62

9

56

13

FIB

 

43

Pavel Poredoš [73]

1996

Case–control study

Slovenia

33

19

12 (66.7); 9 (60.0)

16 (84.2)

63 ± 8.3

69 ± 10.4

NG

63

9.5

FIB

 

44

Thomas Herren [74]

1994

Case–control study

Switzerland

22

13

14 (63.6)

9 (69.2)

64.8

8

63

7.5

FIB

 

45

R. R. Fabsitz [75]

1998

Case–control study

US

women:145

men:81

2401

1597

NG

NG

60.3

59.6

7.9

8

56.1

55.5

7.8

8

FIB

 

46

Agnieszka Okraska-Bylica [76]

2012

Case–control study

Poland

 ≤ 55: 31

 > 55: 32

40

23 (74.2)

25 (78.1)

28 (70)

53

62

3

6.3

52.5

3.3

FIB

 

47

Shuai Bing Li [77]

2013

Cross sectional study

China

145

837

69 (47.5)

251 (30)

62.67

11.12

61.27

10.59

Hcy

FIB

48

G.C.Leng [78]

1995

Cross-sectional study

Scotland

131

722

63 (48.1)

377 (52.2)

66.8

5.7

63.6

5.4

FIB

 

49

Pirjo Mustonen [79]

1998

Case–control study

Finland

15

15

10 (66.7)

10 (66.7)

59

8

57

11

FIB

 

50

Azin Kheirkhah [80]

2020

Case–control study

Austria

248

251

NG

NG

58.3

6.3

56.9

9.5

LPa

 

51

Hugh Tunstall-Pedoe [81]

2017

Cohort study

Scotland

499

NG

NG

NG

    

Lpa

 

52

N. Tmoyan [82]

2017

Case–control study

Russian

61

130

49 (80)

55 (42)

64.1

10.5

54.7

10.5

LPa

53

Nketi I. Forbang [38]

2016

Cohort study

US

4618

NG

NG

NG

NG

NG

NG

NG

LPa

  

54

Anja Laschkolnig [83]

2014

Case–control study

Germany

241

246

241 (100)

246 (100)

58

6

56

9

LPa

 

55

Zi Ye [84]

2012

Case–control study

US

211

NG

NG

NG

NG

NG

NG

NG

LPa + FIB

 

56

Monica L. Bertoia [85]

2013

Case–control study

Korea

women: 144

men: 143

432

429

NG

NG

59.9

65.4

5.2

8.1

60

65.3

5.2

8.1

LPa

 

57

Annie M. Be´rard [86]

2013

Case–control study

French

113

241

89 (78.8)

186 (77.2)

39

7.8

33.1

6

Lpa + FIB + Hcy

58

Deepti Gurdasani [87]

2012

Cohort study

UK

596

212,385

NG

NG

NG

NG

NG

NG

LPa

  

59

Stefano Volpato [88]

2010

Cohort study

Italy

1002

NG

NG

NG

NG

NG

NG

NG

LPa

  

60

Aruna D. Pradhan [89]

2008

Cohort study

US

100

27,835

0

0

59.3

7.3

54.7

7.1

FIB

Hcy

LPa

 

61

Joachim H. Ix [90]

2008

Case–control study

US

104

164

49 (47)

77 (47)

69

10

68

9

Hcy + FIB

 

62

Benjamin Dieplinger [91]

2007

Case–control study

Austria

213

213

158 (74)

158 (74)

66

10.37

66

10.37

LPa

 

63

G.B. Vigna [92]

2006

 

Italy

67

NG

NG

NG

NG

NG

NG

NG

LPa

 

64

Francesco Sof [93]

2005

Case–control study

Italy

280

280

216 (77.1)

216 (77.1)

69

40.7

70

45.9

Hcy + LPa

 

65

Curt Diehm [94]

2004

Cross-sectional study

Germany

1230

NG

NG

NG

NG

NG

NG

NG

LPa

 

66

Paul M. Ridker [95]

2001

Case–control study

US

140

140

NG

NG

58

8.8

57.7

8.9

Hcy

FIB

 

67

Kim Sutton-Tyrrell [96]

1995

Cohort study

US

369

NG

NG

NG

NG

NG

NG

NG

LPa

 

68

Mark Trinder [97]

2020

Cohort study

UK

2283

NG

NG

NG

NG

NG

NG

NG

LPa