Table 1 Baseline characteristics of patients with bladder cancer after local tumor excision and radical cystectomy
Variables | Total | 2–11 months | 12–59 months | 60–119 months | 120 + months | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Observed | Persons | Excess Risk | SMR (95%CI) | Observed | Persons | Excess Risk | SMR (95%CI) | Observed | Persons | Excess Risk | SMR (95%CI) | Observed | Persons | Excess Risk | SMR (95%CI) | Observed | Persons | Excess Risk | SMR (95%CI) | |
Local tumor excision | ||||||||||||||||||||
All | 20,780 | 45,655 | 353.65 | 1.85# (1.82–1.87) | 5453 | 45,655 | 1211.82 | 4.18# (4.07–4.29) | 8096 | 38,024 | 302.9 | 1.77# (1.73–1.81) | 4694 | 22,279 | 152.66 | 1.35# (1.31–1.39) | 2537 | 10,519 | 162.7 | 1.34# (1.28–1.39) |
Age, year | ||||||||||||||||||||
15–54 years | 782 | 4997 | 133.31 | 3.85# (3.58–4.13) | 226 | 4997 | 543.03 | 19.94# (17.42–22.71) | 291 | 4557 | 150.26 | 5.33# (4.74–5.98) | 153 | 3409 | 61.87 | 2.29# (1.95–2.69) | 112 | 2177 | 42.33 | 1.59# (1.31–1.91) |
55–64 years | 1987 | 8405 | 198.84 | 2.66# (2.54–2.77) | 450 | 8405 | 609.53 | 9.25# (8.42–10.15) | 703 | 7531 | 193.42 | 3.17# (2.94–3.41) | 489 | 5131 | 124.06 | 1.99# (1.82–2.17) | 345 | 2800 | 100.67 | 1.49# (1.34–1.65) |
65–74 years | 4684 | 12,338 | 289.68 | 1.95# (1.89–2) | 971 | 12,338 | 849.05 | 5.88# (5.52–6.26) | 1663 | 10,713 | 279.28 | 2.30# (2.19–2.42) | 1142 | 6583 | 157.82 | 1.49# (1.41–1.58) | 908 | 3185 | 133.06 | 1.20# (1.13–1.29) |
75–84 years | 8018 | 13,035 | 427.11 | 1.53# (1.49–1.56) | 1927 | 13,035 | 1524.27 | 4.15# (3.96–4.33) | 3088 | 10,553 | 317.92 | 1.47# (1.42–1.52) | 2042 | 5620 | 74.6 | 1.07# (1.03–1.12) | 961 | 2045 | 309.55 | 1.24# (1.16–1.32) |
85 + years | 5306 | 6860 | 1332.18 | 2.00# (1.95–2.06) | 1878 | 6860 | 2752.94 | 3.05# (2.91–3.19) | 2349 | 4652 | 797.49 | 1.60# (1.53–1.66) | 868 | 1521 | 977.88 | 1.75# (1.63–1.87) | 211 | 303 | 2704.32 | 3.13# (2.72–3.58) |
Year of diagnosis | ||||||||||||||||||||
2000–2007 | 11,960 | 19,150 | 288.4 | 1.67# (1.64–1.7) | 2326 | 19,150 | 1181.94 | 3.98# (3.82–4.14) | 3982 | 16,785 | 291.86 | 1.73# (1.68–1.78) | 3163 | 12,715 | 135.85 | 1.31# (1.26–1.35) | 2489 | 9398 | 158.96 | 1.33# (1.28–1.38) |
2008–2012 | 5426 | 12,194 | 367.15 | 1.92# (1.87–1.97) | 1453 | 12,194 | 1176.14 | 4.16# (3.95–4.38) | 2444 | 10,688 | 277.41 | 1.72# (1.65–1.79) | 1481 | 8090 | 186.85 | 1.43# (1.36–1.51) | 48 | 1121 | 428.7 | 1.94# (1.43–2.57) |
2013–2017 | 3233 | 12,273 | 628.45 | 2.66# (2.56–2.75) | 1513 | 12,273 | 1253.43 | 4.41# (4.19–4.63) | 1670 | 10,551 | 374.34 | 1.98# (1.88–2.07) | 50 | 1474 | 298.36 | 1.73# (1.28–2.28) | 0 | 0 | 0 | 0 (0–0) |
Race | ||||||||||||||||||||
White | 18,245 | 40,410 | 325.72 | 1.77# (1.74–1.8) | 4637 | 40,410 | 1138.43 | 3.95# (3.83–4.06) | 7046 | 33,881 | 275.42 | 1.69# (1.65–1.73) | 4230 | 20,212 | 141.37 | 1.32# (1.28–1.36) | 2332 | 9648 | 156.81 | 1.32# (1.27–1.37) |
Black | 1810 | 3254 | 792.24 | 2.83# (2.7–2.96) | 624 | 3254 | 2298.18 | 6.68# (6.17–7.23) | 746 | 2481 | 683.25 | 2.65# (2.46–2.85) | 318 | 1193 | 343.03 | 1.74# (1.56–1.95) | 122 | 476 | 233.05 | 1.49# (1.24–1.78) |
American Indian/Alaska Native | 48 | 107 | 710.02 | 4.71# (3.47–6.25) | 14 | 107 | 1601.65 | 9.70# (5.3–16.28) | 25 | 86 | 954.66 | 6.74# (4.36–9.94) | 2 | 41 | − 82.54 | 0.61 (0.07–2.22) | 7 | 24 | 661.59 | 3.94# (1.58–8.12) |
Asian or Pacific Islander | 677 | 1884 | 367.07 | 2.26# (2.1–2.44) | 178 | 1884 | 995.92 | 4.89# (4.2–5.67) | 279 | 1576 | 335.5 | 2.24# (1.98–2.51) | 144 | 833 | 187.63 | 1.61# (1.36–1.9) | 76 | 371 | 200.85 | 1.56# (1.23–1.95) |
Differentiation | ||||||||||||||||||||
Well-differentiated | 2425 | 6461 | 75.08 | 1.20# (1.15–1.25) | 214 | 6461 | 91.32 | 1.29# (1.12–1.47) | 864 | 6205 | 54.71 | 1.16# (1.08–1.24) | 801 | 4596 | 74.27 | 1.19# (1.11–1.27) | 546 | 2446 | 113.63 | 1.25# (1.15–1.36) |
Moderately differentiated | 5288 | 13,730 | 117.98 | 1.30# (1.26–1.33) | 639 | 13,730 | 248.61 | 1.76# (1.62–1.9) | 1850 | 13,009 | 81.56 | 1.23# (1.17–1.28) | 1695 | 8245 | 105.66 | 1.25# (1.19–1.31) | 1104 | 4617 | 144.5 | 1.31# (1.23–1.38) |
Poorly differentiated | 4902 | 7218 | 789.82 | 2.60# (2.53–2.68) | 1693 | 7218 | 2836.00 | 6.96# (6.63–7.3) | 1882 | 5479 | 691.45 | 2.46# (2.35–2.57) | 878 | 3119 | 285.37 | 1.57# (1.47–1.67) | 449 | 1537 | 229.89 | 1.42# (1.29–1.56) |
Undifferentiated | 5682 | 10,018 | 1,003.81 | 3.04# (2.96–3.12) | 2216 | 10,018 | 2634.29 | 6.64# (6.36–6.92) | 2465 | 7717 | 824.37 | 2.74# (2.63–2.85) | 745 | 2857 | 307.42 | 1.59# (1.48–1.71) | 256 | 1007 | 313.72 | 1.54# (1.35–1.74) |
Unknown | 2322 | 6190 | 263.09 | 1.69# (1.62–1.75) | 530 | 6190 | 740.43 | 3.11# (2.85–3.39) | 1035 | 5614 | 216.31 | 1.59# (1.5–1.69) | 575 | 3462 | 149.68 | 1.36# (1.25–1.48) | 182 | 912 | 154.56 | 1.35# (1.16–1.56) |
Pathological type | ||||||||||||||||||||
8130/3: papillary transitional cell carcinoma | 13,058 | 34,058 | 171.44 | 1.42# (1.39–1.44) | 1888 | 34,058 | 346.59 | 1.96# (1.87–2.05) | 5254 | 30,448 | 161.19 | 1.42# (1.38–1.46) | 3774 | 18,797 | 127.75 | 1.30# (1.26–1.34) | 2142 | 9041 | 149.73 | 1.31# (1.25–1.36) |
8120/3: transitional cell carcinoma, NOS | 6089 | 9282 | 1190.93 | 3.51# (3.42–3.6) | 2660 | 9282 | 3861.82 | 9.18# (8.84–9.54) | 2328 | 6243 | 960.35 | 3.12# (2.99–3.25) | 775 | 2870 | 301.13 | 1.60# (1.49–1.72) | 326 | 1183 | 257.41 | 1.51# (1.35–1.68) |
8070/3: squamous cell carcinoma, NOS | 421 | 475 | 5377.79 | 13.35# (12.11–14.69) | 296 | 475 | 13,208.44 | 27.42# (24.38–30.72) | 100 | 168 | 2778.97 | 7.56# (6.16–9.2) | 21 | 47 | 1160.00 | 4.02# (2.49–6.15) | 4 | 14 | 284.77 | 1.75 (0.48–4.47) |
8010/3: carcinoma, NOS | 166 | 262 | 959.88 | 3.13# (2.68–3.65) | 78 | 262 | 4175.02 | 10.86# (8.58–13.55) | 55 | 172 | 700.93 | 2.73# (2.05–3.55) | 23 | 96 | 128.36 | 1.26 (0.8–1.88) | 10 | 42 | 184.47 | 1.37 (0.66–2.52) |
8140/3: adenocarcinoma, NOS | 162 | 250 | 1436.30 | 6.02# (5.13–7.02) | 65 | 250 | 3645.14 | 12.89# (9.95–16.43) | 74 | 172 | 1493.70 | 6.89# (5.41–8.65) | 15 | 73 | 321.54 | 2.07# (1.16–3.41) | 8 | 27 | 369.81 | 2.07 (0.89–4.08) |
8041/3: small cell carcinoma, NOS | 124 | 169 | 2688.94 | 6.60# (5.49–7.87) | 74 | 169 | 7167.67 | 16.55# (12.99–20.77) | 40 | 84 | 1758.03 | 4.96# (3.55–6.76) | 7 | 29 | 236.32 | 1.44 (0.58–2.97) | 3 | 8 | 738.72 | 2.14 (0.44–6.26) |
8071/3: squamous cell carcinoma, keratinizing, NOS | 117 | 129 | 6735.71 | 15.67# (12.96–18.78) | 94 | 129 | 17,566.75 | 35.52# (28.71–43.47) | 16 | 33 | 2062.71 | 5.26# (3–8.53) | 6 | 12 | 1339.84 | 3.91# (1.44–8.52) | 1 | 4 | 523 | 4.1 (0.1–22.87) |
8050/3: papillary carcinoma, NOS | 106 | 214 | 196.02 | 1.48# (1.21–1.79) | 20 | 214 | 818.66 | 3.23# (1.97–4.99) | 36 | 194 | 192.87 | 1.53# (1.07–2.11) | 26 | 133 | 59.45 | 1.14 (0.75–1.68) | 24 | 94 | 125.65 | 1.26 (0.81–1.88) |
Radical cystectomy | ||||||||||||||||||||
All | 3260 | 5385 | 1137.11 | 4.68# (4.52–4.84) | 1155 | 5385 | 2778.17 | 13.07# (12.32–13.84) | 1526 | 3957 | 1259.28 | 5.68# (5.4–5.97) | 376 | 1730 | 264.95 | 1.73# (1.56–1.91) | 203 | 773 | 294.24 | 1.65# (1.43–1.9) |
Age, year | ||||||||||||||||||||
15–54 years | 375 | 766 | 854.88 | 19.11# (17.22–21.15) | 125 | 766 | 2152.25 | 71.35# (59.39–85.01) | 201 | 605 | 1190.37 | 33.69# (29.19–38.68) | 34 | 305 | 231.88 | 5.55# (3.85–7.76) | 15 | 179 | 123.95 | 2.59# (1.45–4.28) |
55–64 years | 669 | 1281 | 1009.47 | 9.93# (9.19–10.71) | 216 | 1,281 | 2232.86 | 30.79# (26.82–35.18) | 352 | 994 | 1,282.28 | 15.40# (13.84–17.1) | 66 | 457 | 271.16 | 3.14# (2.43–3.99) | 35 | 226 | 232.02 | 2.12# (1.48–2.95) |
65–74 years | 1089 | 1801 | 1215.39 | 5.24# (4.93–5.56) | 372 | 1,801 | 2695.54 | 16.37# (14.75–18.12) | 523 | 1,328 | 1391.19 | 7.56# (6.93–8.24) | 116 | 549 | 306.46 | 1.95# (1.61–2.34) | 78 | 237 | 253.67 | 1.38# (1.09–1.72) |
75–84 years | 965 | 1337 | 1337.07 | 2.84# (2.67–3.03) | 365 | 1337 | 3544.89 | 8.90# (8.01–9.87) | 389 | 913 | 1100.31 | 2.80# (2.52–3.09) | 144 | 384 | 221.93 | 1.22# (1.03–1.44) | 67 | 121 | 807.78 | 1.62# (1.25–2.05) |
85 + years | 160 | 196 | 2044.26 | 2.54# (2.16–2.97) | 77 | 196 | 5197.02 | 4.84# (3.82–6.05) | 59 | 113 | 1152.30 | 1.86# (1.42–2.4) | 16 | 34 | 315.24 | 1.24 (0.71–2.02) | 8 | 9 | 2,665.53 | 3.16# (1.36–6.22) |
Year of diagnosis | ||||||||||||||||||||
2000–2007 | 1758 | 2275 | 983.27 | 3.85# (3.67–4.03) | 543 | 2275 | 3056.31 | 13.24# (12.15–14.4) | 748 | 1727 | 1261.04 | 5.34# (4.97–5.74) | 266 | 965 | 272.26 | 1.72# (1.52–1.94) | 201 | 685 | 297.14 | 1.66# (1.44–1.9) |
2008–2012 | 887 | 1434 | 1200.85 | 5.41# (5.06–5.77) | 328 | 1434 | 2905.97 | 14.02# (12.54–15.62) | 453 | 1098 | 1211.21 | 5.75# (5.23–6.31) | 104 | 627 | 237.05 | 1.72# (1.41–2.08) | 2 | 88 | 121.81 | 1.38 (0.17–4.98) |
2013–2017 | 596 | 1424 | 1631.79 | 8.00# (7.37–8.67) | 265 | 1424 | 2293.54 | 11.84# (10.46–13.36) | 325 | 1132 | 1326.86 | 6.50# (5.81–7.24) | 6 | 138 | 591.62 | 2.82# (1.04–6.14) | 0 | 0 | 0 | 0 (0–0) |
Race | ||||||||||||||||||||
White | 2750 | 4541 | 1108.75 | 4.43# (4.26–4.6) | 956 | 4541 | 2707.18 | 12.37# (11.6–13.18) | 1282 | 3361 | 1222.55 | 5.37# (5.08–5.68) | 330 | 1481 | 261.54 | 1.68# (1.51–1.88) | 182 | 658 | 316.37 | 1.66# (1.43–1.92) |
Black | 365 | 557 | 1464.79 | 6.39# (5.75–7.08) | 139 | 557 | 3365.11 | 16.23# (13.64–19.16) | 178 | 389 | 1724.63 | 7.96# (6.83–9.22) | 33 | 155 | 331.37 | 2.14# (1.48–3.01) | 15 | 71 | 150.01 | 1.39 (0.78–2.29) |
American Indian/Alaska Native | 11 | 21 | 1554.96 | 19.42# (9.69–34.74) | 7 | 21 | 4314.66 | 41.26# (16.59–85.01) | 3 | 14 | 718.68 | 10.48# (2.16–30.62) | 0 | 5 | -81.03 | 0 (0–34.78) | 1 | 1 | 23,765.73 | 224.52# (5.68–1250.94) |
Asian or Pacific Islander | 134 | 266 | 989.52 | 7.26# (6.08–8.59) | 53 | 266 | 2665.39 | 22.47# (16.83–29.4) | 63 | 193 | 1089.87 | 8.24# (6.33–10.54) | 13 | 89 | 223.1 | 2.20# (1.17–3.76) | 5 | 43 | 160.87 | 1.95 (0.63–4.56) |
Differentiation | ||||||||||||||||||||
Well-differentiated | 39 | 58 | 930.35 | 4.13# (2.94–5.65) | 12 | 58 | 2578.68 | 13.20# (6.82–23.06) | 15 | 46 | 822.44 | 4.16# (2.33–6.86) | 11 | 27 | 786.27 | 3.21# (1.6–5.75) | 1 | 9 | -125.31 | 0.67 (0.02–3.72) |
Moderately differentiated | 245 | 382 | 1095.85 | 5.31# (4.67–6.02) | 87 | 382 | 2963.45 | 16.48# (13.2–20.32) | 111 | 294 | 1183.86 | 6.34# (5.21–7.63) | 33 | 145 | 375.09 | 2.34# (1.61–3.28) | 14 | 74 | 194.28 | 1.52 (0.83–2.55) |
Poorly differentiated | 1245 | 1731 | 1235.17 | 4.81# (4.55–5.09) | 445 | 1731 | 3367.21 | 15.09# (13.72–16.55) | 565 | 1275 | 1446.01 | 6.14# (5.64–6.67) | 143 | 607 | 275.36 | 1.75# (1.48–2.06) | 92 | 318 | 291.88 | 1.66# (1.34–2.04) |
Undifferentiated | 1560 | 2692 | 1088.28 | 4.41# (4.2–4.64) | 540 | 2692 | 2467.14 | 11.41# (10.47–12.41) | 764 | 2126 | 1192.41 | 5.34# (4.97–5.74) | 172 | 851 | 220.4 | 1.57# (1.34–1.82) | 84 | 329 | 289.44 | 1.58# (1.26–1.95) |
Unknown | 152 | 270 | 998.55 | 5.41# (4.59–6.34) | 52 | 270 | 2425.40 | 13.81# (10.32–18.11) | 71 | 216 | 1012.22 | 5.61# (4.38–7.08) | 17 | 100 | 255.57 | 2.03# (1.18–3.24) | 12 | 43 | 677.04 | 3.67# (1.89–6.4) |
Pathological type | ||||||||||||||||||||
8120/3: transitional cell carcinoma, NOS | 1813 | 2906 | 1222.50 | 4.74# (4.52–4.96) | 637 | 2906 | 2846.27 | 12.88# (11.9–13.92) | 873 | 2127 | 1393.34 | 5.95# (5.56–6.35) | 195 | 885 | 249.03 | 1.64# (1.42–1.89) | 108 | 398 | 296.68 | 1.60# (1.32–1.94) |
8130/3: papillary transitional cell carcinoma | 767 | 1449 | 780.42 | 3.45# (3.21–3.7) | 212 | 1449 | 1732.85 | 8.33# (7.24–9.53) | 369 | 1154 | 905.2 | 4.27# (3.84–4.73) | 122 | 561 | 268.95 | 1.73# (1.44–2.06) | 64 | 246 | 277.35 | 1.60# (1.23–2.05) |
8070/3: squamous cell carcinoma, NOS | 219 | 324 | 1475.83 | 6.59# (5.75–7.53) | 116 | 324 | 5319.09 | 27.88# (23.04–33.44) | 74 | 200 | 1186.43 | 5.96# (4.68–7.48) | 17 | 98 | 182.44 | 1.59 (0.93–2.55) | 12 | 45 | 330.84 | 2.01# (1.04–3.51) |
8071/3: squamous cell carcinoma, keratinizing, NOS | 73 | 118 | 1335.20 | 5.66# (4.44–7.12) | 42 | 118 | 5275.67 | 24.35# (17.55–32.91) | 22 | 72 | 869.1 | 4.19# (2.63–6.35) | 5 | 37 | 119.05 | 1.41 (0.46–3.29) | 4 | 14 | 274.06 | 1.68 (0.46–4.31) |
8122/3: transitional cell carcinoma, spindle cell | 68 | 104 | 2379.77 | 10.05# (7.8–12.74) | 43 | 104 | 6400.21 | 32.04# (23.19–43.16) | 19 | 53 | 1383.53 | 6.48# (3.9–10.12) | 5 | 19 | 464.74 | 2.5 (0.81–5.84) | 1 | 6 | 440.6 | 2.02 (0.05–11.27) |
8140/3: Adenocarcinoma, NOS | 61 | 89 | 1301.96 | 7.40# (5.66–9.5) | 17 | 89 | 2396.29 | 15.22# (8.87–24.37) | 30 | 65 | 1526.49 | 10.34# (6.98–14.76) | 8 | 29 | 543.81 | 3.72# (1.61–7.34) | 6 | 16 | 728.82 | 2.88# (1.06–6.27) |