From: Plasma S-Klotho level affects the risk of hyperuricemia in the middle-aged and elderly people
Characteristic | Total population | S-Klotho levels quartiles, pg/ml | P value | |||
---|---|---|---|---|---|---|
Q1 | Q2 | Q3 | Q4 | |||
 | 843.6 (833.6,853.6) |  < 653.9 |  ≥ 653.9 to < 801.3 |  ≥ 801.3 to < 992.5 |  ≥ 992.5 |  |
Age | 56.29 (55.99,56.60) | 57.46 (57.01,57.91) | 56.46 (55.92,57.00) | 55.89 (55.48,56.31) | 55.26 (54.77,55.75) |  < 0.001 |
Gender (%) |  |  |  |  |  |  < 0.001 |
Man | 48.02 (47.08,48.96) | 49.13 (46.88,51.38) | 51.08 (48.96,53.18) | 48.18 (45.99,50.37) | 43.28 (41.04,45.54) | Â |
Woman | 51.98 (51.04,52.92) | 50.87 (48.62,53.12) | 48.92 (46.82,51.04) | 51.82 (49.63,54.01) | 56.72 (54.46,58.96) | Â |
Race/ethnicity (%) |  |  |  |  |  |  < 0.001 |
Mexican American | 6.48 | 6.41 | 5.97 | 6.76 | 6.84 | Â |
Other Hispanic | 4.55 | 3.95 | 4.26 | 4.59 | 5.45 | Â |
Non-Hispanic White | 73.97 | 74.63 | 77.07 | 74.7 | 69.03 | Â |
Non-Hispanic Black | 9.03 | 9.06 | 7.28 | 7.43 | 12.67 | Â |
Other Race | 5.97 | 5.95 | 5.42 | 6.52 | 6.01 | Â |
Blood pressure (%) | Â | Â | Â | Â | Â | 0.002 |
Non-hypertension | 58.25 | 54.91 | 59.08 | 60.62 | 58.23 | Â |
hypertension | 41.75 | 45.09 | 40.92 | 39.38 | 41.77 | Â |
Smoke (%) |  |  |  |  |  |  < 0.001 |
Don't smoke | 51.39 | 47.16 | 50.11 | 52.07 | 56.54 | Â |
still smoking | 18.42 | 20.92 | 19.55 | 17.23 | 15.82 | Â |
quit smoking | 30.19 | 31.92 | 30.34 | 30.7 | 27.64 | Â |
Alcohol |  |  |  |  |  |  < 0.001 |
Don't drink | 10.55 | 8.87 | 10.91 | 9.91 | 12.6 | Â |
Drink a lot | 77.47 | 80.49 | 78.57 | 77.43 | 73.12 | Â |
Drink occasionally | 11.98 | 10.64 | 10.52 | 12.66 | 14.28 | Â |
Physical activity (%) |  |  |  |  |  |  < 0.001 |
Vigorous recreational activities | 15.06 | 16.7 | 18.59 | 20.48 | 19.8 | Â |
Moderate recreational activities | 28.51 | 33.52 | 33.02 | 30.35 | 29.54 | Â |
Lack of recreational activities | 56.43 | 49.78 | 48.39 | 49.18 | 50.66 | Â |
Body mass index (kg/m2) | 29.57 (29.37,29.78) | 29.67 (29.37,29.97) | 29.63 (29.29,29.97) | 29.63 (29.27,29.99) | 29.34 (28.95,29.73) | 0.489 |
Urea (mmol/l) | 5.07 (5.01,5.13) | 5.24 (5.15,5.33) | 5.09 (5.00,5.17) | 5.01 (4.92,5.11) | 4.84 (4.74,4.94) |  < 0.001 |
Creatinine (mmol/l) | 79.69 (78.83,80.55) | 81.91 (80.83,83.00) | 79.13 (78.13,80.13) | 77.51 (76.69,78.33) | 75.00 (74.15,75.84) |  < 0.001 |
Total cholesterol (mmol/l) | 5.21 (5.17,5.24) | 5.23 (5.16,5.30) | 5.21 (5.15,5.26) | 5.20 (5.14,5.26) | 5.19 (5.13,5.25) | 0.865 |
Triglyceride (mmol/l) | 1.88 (1.83,1.92) | 1.99 (1.87,2.12) | 1.90 (1.83,1.97) | 1.84 (1.79,1.90) | 1.77 (1.70,1.84) | 0.001 |
High density cholesterol (mmol/l) | 1.40 (1.39,1.42) | 1.41 (1.38,1.44) | 1.38 (1.36,1.40) | 1.40 (1.38,1.42) | 1.42 (1.40,1.44) | 0.042 |
Low density cholesterol (mmol/l) | 3.43 (3.40,3.46) | 3.42 (3.36,3.48) | 3.45 (3.39,3.50) | 3.43 (3.39,3.48) | 3.42 (3.37,3.47) | 0.921 |
Hyperuricemia |  |  |  |  |  |  < 0.001 |
No | 81.08 (79.81,82.28) | 75.23 (73.03,77.30) | 80.49 (78.29,82.52) | 83.18 (81.19,85.01) | 85.68 (83.55,87.57) | Â |
Yes | 18.92 (17.72,20.19) | 24.77 (22.70,26.97) | 19.51 (17.48,21.71) | 16.82 (14.99,18.81) | 14.32 (12.43,16.45) | Â |
Fasting blood glucose (mmol/l) | 5.79 (5.73,5.85) | 5.64 (5.57,5.71) | 5.70 (5.60,5.80) | 5.77 (5.69,5.85) | 6.07 (5.94,6.20) |  < 0.001 |
Glycosylated haemoglobin (%) | 5.80 (5.77,5.83) | 5.7 (5.7, 5.8) | 5.7 (5.7, 5.8) | 5.7 (5.7, 5.8) | 5.9 (5.9, 6.0) |  < 0.001 |
Heart failure (%) |  |  |  |  |  |  < 0.001 |
No | 97.08 (96.73,97.39) | 95.84 (94.99,96.56) | 97.53 (96.86,98.06) | 97.22 (96.51,97.79) | 97.85 (97.20,98.35) | Â |
Yes | 2.92 (2.61,3.27) | 4.16 (3.44,5.01) | 2.47 (1.94,3.14) | 2.78 (2.21,3.49) | 2.15 (1.65,2.80) | Â |
Coronary heart disease (%) | Â | Â | Â | Â | Â | 0.034 |
No | 95.65 (95.11,96.13) | 94.71 (93.71,95.56) | 95.80 (94.78,96.62) | 95.77 (94.82,96.55) | 96.42 (95.30,97.28) | Â |
Yes | 4.35 (3.87,4.89) | 5.29 (4.44,6.29) | 4.20 (3.38,5.22) | 4.23 (3.45,5.18) | 3.58 (2.72,4.70) | Â |
Stroke (%) | Â | Â | Â | Â | Â | 0.089 |
No | 96.68 (96.31,97.01) | 96.04 (95.00,96.88) | 96.74 (95.97,97.36) | 96.99 (96.31,97.55) | 97.16 (96.37,97.78) | Â |
Yes | 3.32 (2.99,3.69) | 3.96 (3.12,5.00) | 3.26 (2.64,4.03) | 3.01 (2.45,3.69) | 2.84 (2.22,3.63) | Â |
Diabetes (%) | Â | Â | Â | Â | Â | 0.159 |
No | 86.63 (85.60,87.59) | 85.77 (84.05,87.32) | 86.77 (84.79,88.53) | 88.07 (86.68,89.33) | 86.23 (84.37,87.90) | Â |
Yes | 13.37 (12.41,14.40) | 14.23 (12.68,15.95) | 13.23 (11.47,15.21) | 11.93 (10.67,13.32) | 13.77 (12.10,15.63) | Â |
eGFRCKD–EPI (ml/min/1.73m2) | 85.73 (85.15,86.30) | 82.70 (81.82,83.58) | 85.68 (84.71,86.64) | 86.79 (86.10,87.48) | 88.61 (87.79,89.43) |  < 0.001 |