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Table 1 Baseline characteristics of participants

From: Plasma S-Klotho level affects the risk of hyperuricemia in the middle-aged and elderly people

Characteristic

Total population

S-Klotho levels quartiles, pg/ml

P value

Q1

Q2

Q3

Q4

 

843.6 (833.6,853.6)

 < 653.9

 ≥ 653.9 to < 801.3

 ≥ 801.3 to < 992.5

 ≥ 992.5

 

Age

56.29 (55.99,56.60)

57.46 (57.01,57.91)

56.46 (55.92,57.00)

55.89 (55.48,56.31)

55.26 (54.77,55.75)

 < 0.001

Gender (%)

     

 < 0.001

Man

48.02 (47.08,48.96)

49.13 (46.88,51.38)

51.08 (48.96,53.18)

48.18 (45.99,50.37)

43.28 (41.04,45.54)

 

Woman

51.98 (51.04,52.92)

50.87 (48.62,53.12)

48.92 (46.82,51.04)

51.82 (49.63,54.01)

56.72 (54.46,58.96)

 

Race/ethnicity (%)

     

 < 0.001

Mexican American

6.48

6.41

5.97

6.76

6.84

 

Other Hispanic

4.55

3.95

4.26

4.59

5.45

 

Non-Hispanic White

73.97

74.63

77.07

74.7

69.03

 

Non-Hispanic Black

9.03

9.06

7.28

7.43

12.67

 

Other Race

5.97

5.95

5.42

6.52

6.01

 

Blood pressure (%)

     

0.002

Non-hypertension

58.25

54.91

59.08

60.62

58.23

 

hypertension

41.75

45.09

40.92

39.38

41.77

 

Smoke (%)

     

 < 0.001

Don't smoke

51.39

47.16

50.11

52.07

56.54

 

still smoking

18.42

20.92

19.55

17.23

15.82

 

quit smoking

30.19

31.92

30.34

30.7

27.64

 

Alcohol

     

 < 0.001

Don't drink

10.55

8.87

10.91

9.91

12.6

 

Drink a lot

77.47

80.49

78.57

77.43

73.12

 

Drink occasionally

11.98

10.64

10.52

12.66

14.28

 

Physical activity (%)

     

 < 0.001

Vigorous recreational activities

15.06

16.7

18.59

20.48

19.8

 

Moderate recreational activities

28.51

33.52

33.02

30.35

29.54

 

Lack of recreational activities

56.43

49.78

48.39

49.18

50.66

 

Body mass index (kg/m2)

29.57 (29.37,29.78)

29.67 (29.37,29.97)

29.63 (29.29,29.97)

29.63 (29.27,29.99)

29.34 (28.95,29.73)

0.489

Urea (mmol/l)

5.07 (5.01,5.13)

5.24 (5.15,5.33)

5.09 (5.00,5.17)

5.01 (4.92,5.11)

4.84 (4.74,4.94)

 < 0.001

Creatinine (mmol/l)

79.69 (78.83,80.55)

81.91 (80.83,83.00)

79.13 (78.13,80.13)

77.51 (76.69,78.33)

75.00 (74.15,75.84)

 < 0.001

Total cholesterol (mmol/l)

5.21 (5.17,5.24)

5.23 (5.16,5.30)

5.21 (5.15,5.26)

5.20 (5.14,5.26)

5.19 (5.13,5.25)

0.865

Triglyceride (mmol/l)

1.88 (1.83,1.92)

1.99 (1.87,2.12)

1.90 (1.83,1.97)

1.84 (1.79,1.90)

1.77 (1.70,1.84)

0.001

High density cholesterol (mmol/l)

1.40 (1.39,1.42)

1.41 (1.38,1.44)

1.38 (1.36,1.40)

1.40 (1.38,1.42)

1.42 (1.40,1.44)

0.042

Low density cholesterol (mmol/l)

3.43 (3.40,3.46)

3.42 (3.36,3.48)

3.45 (3.39,3.50)

3.43 (3.39,3.48)

3.42 (3.37,3.47)

0.921

Hyperuricemia

     

 < 0.001

No

81.08 (79.81,82.28)

75.23 (73.03,77.30)

80.49 (78.29,82.52)

83.18 (81.19,85.01)

85.68 (83.55,87.57)

 

Yes

18.92 (17.72,20.19)

24.77 (22.70,26.97)

19.51 (17.48,21.71)

16.82 (14.99,18.81)

14.32 (12.43,16.45)

 

Fasting blood glucose (mmol/l)

5.79 (5.73,5.85)

5.64 (5.57,5.71)

5.70 (5.60,5.80)

5.77 (5.69,5.85)

6.07 (5.94,6.20)

 < 0.001

Glycosylated haemoglobin (%)

5.80 (5.77,5.83)

5.7 (5.7, 5.8)

5.7 (5.7, 5.8)

5.7 (5.7, 5.8)

5.9 (5.9, 6.0)

 < 0.001

Heart failure (%)

     

 < 0.001

No

97.08 (96.73,97.39)

95.84 (94.99,96.56)

97.53 (96.86,98.06)

97.22 (96.51,97.79)

97.85 (97.20,98.35)

 

Yes

2.92 (2.61,3.27)

4.16 (3.44,5.01)

2.47 (1.94,3.14)

2.78 (2.21,3.49)

2.15 (1.65,2.80)

 

Coronary heart disease (%)

     

0.034

No

95.65 (95.11,96.13)

94.71 (93.71,95.56)

95.80 (94.78,96.62)

95.77 (94.82,96.55)

96.42 (95.30,97.28)

 

Yes

4.35 (3.87,4.89)

5.29 (4.44,6.29)

4.20 (3.38,5.22)

4.23 (3.45,5.18)

3.58 (2.72,4.70)

 

Stroke (%)

     

0.089

No

96.68 (96.31,97.01)

96.04 (95.00,96.88)

96.74 (95.97,97.36)

96.99 (96.31,97.55)

97.16 (96.37,97.78)

 

Yes

3.32 (2.99,3.69)

3.96 (3.12,5.00)

3.26 (2.64,4.03)

3.01 (2.45,3.69)

2.84 (2.22,3.63)

 

Diabetes (%)

     

0.159

No

86.63 (85.60,87.59)

85.77 (84.05,87.32)

86.77 (84.79,88.53)

88.07 (86.68,89.33)

86.23 (84.37,87.90)

 

Yes

13.37 (12.41,14.40)

14.23 (12.68,15.95)

13.23 (11.47,15.21)

11.93 (10.67,13.32)

13.77 (12.10,15.63)

 

eGFRCKD–EPI (ml/min/1.73m2)

85.73 (85.15,86.30)

82.70 (81.82,83.58)

85.68 (84.71,86.64)

86.79 (86.10,87.48)

88.61 (87.79,89.43)

 < 0.001

  1. Continuous variables are described by average ± standard deviation or median (quartile spacing); description of adoption rate and constituent ratio of classified variables
  2. Urea, Creatinine, Total cholesterol, Triglyceride, High density cholesterol, Low density cholesterol, Fasting blood glucose: (mmol/l)