Table 1 Mutations of grlA, grlB, gyrA and gyrB and resistance phenotypes of QR-MRSA
No. isolates | SCCmec types | Spa types | MLST | Mutation positions | Phenotypic resistance | MIC (mg/L) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
norA | grlA | grlB | gyrA | gyrB | MRSA | QR-MRSA | MDR | XDR | PDR | CIP | GAT | OFL | NOR | VitK | CIP | ||||
SA.01 | I | t037 | ST30 | G → A | T2460G | A1578G | C2402T | A1578G | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 32 | 64 |
SA.03 | I | t037 | ST108 | G → A | T2460G | A1578G | C2402T | A1578G | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 32 | 64 |
SA.05 | II | t037 | ST108 | NONE | A1578G | T1497C | NONE | T1497C | Positive | Positive | Positive | Positive | Negative | R | I | I | I | 32 | 64 |
SA.06 | I | t037 | ST30 | A → G | T2460G | A1578G | T2409C | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 16 | 32 |
SA.07 | II | t037 | ST30 | NONE | A1578G | A1578G | T2409C | T1497C | Positive | Positive | Positive | Positive | Negative | R | I | R | I | 16 | 64 |
SA.09 | III | t037 | ST30 | A → G | T2460G | T1497C | T2460G | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 16 | 32 |
SA.11 | IV | t037 | ST30 | NONE | A1578G | T1497C | T2460G | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | S | 161 | 64 |
SA.13 | IV | t021 | ST21 | C → T | T2460G | T1497C | NONE | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 6 | 32 |
SA.15 | III | t021 | ST22 | A → G | T2460G | T1497C | T2409C | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 16 | 32 |
SA.17 | III | t030 | ST22 | NONE | A1578G | T1497C | NONE | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | I | I | 161 | 32 |
SA.22 | IV | t037 | ST108 | NONE | A1578G | T1497C | T2409C | A1578G | Positive | Positive | Positive | Positive | Negative | R | R | R | I | 16 | 32 |
SA.23 | V | t037 | ST15 | A → G | T2460G | A1578G | T2409C | A1578G | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 16 | 32 |
SA.24 | III | t044 | ST780 | A → G | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 16 | 32 |
SA.25 | III | t044 | ST02 | C → T | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 8 | 32 |
SA.28 | V | t037 | ST15 | C → T | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 8 | 16 |
SA.30 | III | t090 | ST15 | A → G | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 32 | 16 |
SA.31 | III | t044 | ST15 | A → G | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 32 | 16 |
SA.32 | V | t044 | ST45 | A → G | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 32 | 64 |
SA.33 | IV | t030 | ST298 | A → G | T2460G | A1578G | T2409C | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 8 | 64 |
SA.36 | IV | t021 | ST360 | NONE | A1578G | A1578G | T2409C | A1578G | Positive | Positive | Positive | Positive | Negative | R | R | R | I | 8 | 16 |
SA.48 | V | t030 | ST30 | A → G | A1578G | T1497C | T2460G | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 32 | 128 |
SA.49 | IV | t030 | ST311 | G → A | T2460G | T1497C | T2460G | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 32 | 128 |
SA.50 | V | t030 | ST22 | G → A | A1578G | A1578G | T2460G | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 32 | 32 |
SA.51 | III | t030 | ST22 | A → G | T2460G | A1578G | T2409C | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 32 | 32 |
SA.52 | V | t030 | ST22 | NONE | NONE | T1497C | T2460G | A1578G | Positive | Positive | Positive | Negative | Negative | R | R | R | S | 32 | 32 |
SA.53 | V | t030 | ST508 | NONE | A1578G | T1497C | NONE | A1578G | Positive | Positive | Positive | Negative | Negative | R | R | R | S | 32 | 32 |
SA.54 | V | t030 | ST992 | A → G | A1578G | T1497C | C2402T | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 8 | 16 |
SA.55 | V | t304 | ST982 | A → G | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 8 | 16 |
SA.56 | III | t044 | ST780 | A → G | A1578G | T1497C | T2460G | A1578G | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 8 | 16 |
SA.57 | V | t044 | ST500 | C → T | A1578G | T1497C | C2402T | A1578G | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 16 | 64 |
SA.58 | IV | t044 | ST93 | C → T | A1578G | T1497C | T2460G | A1578G | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 16 | 64 |
SA.59 | IV | t044 | ST189 | C → T | A1578G | T1497C | T2460G | A1578G | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 16 | 64 |
SA.60 | IV | t044 | ST17 | A → G | A1578G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 16 | 64 |
SA.61 | IV | t044 | ST19 | A → G | A1578G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 16 | 64 |
SA.62 | V | t267 | ST839 | A → G | A1578G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 16 | 16 |
SA.63 | IV | t267 | ST902 | C → T | T2460G | A1578G | T2460G | A1578G | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 8 | 16 |
SA.64 | IV | t267 | ST60 | C → T | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Negative | Negative | R | R | R | R | 8 | 32 |
SA.65 | IV | t267 | ST839 | A → G | A1578G | T1497C | T2460G | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 8 | 16 |
SA.66 | IV | t267 | ST832 | A → G | A1578G | T1497C | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 8 | 16 |
SA.67 | IV | t044 | ST260 | A → G | T2460G | A1578G | C2402T | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 8 | 16 |
SA.68 | V | t044 | ST171 | C → T | T2460G | A1578G | T2460G | T1497C | Positive | Positive | Positive | Positive | Negative | R | R | R | R | 8 | 16 |