Inhibitory activities of vitamins K2 against clinical isolates of quinolone-resistant and methicillin-resistant Staphylococcus aureus (QR-MRSA) with different multi-locus sequence types (MLST), SCCmec, and spa types

Pasandideh, Naime Kashefi; Tahmasebi, Hamed; Dehbashi, Sanaz; zeyni, Behrouz; Arabestani, Mohammad Reza

doi:10.1186/s40001-022-00939-x

Table 2 Pearson (r) and χ2 (p) correlation between antibiotic resistance, efflux pump gene expression profile, vitamin K₂ and molecular typing in of S. aureus isolates

From: Inhibitory activities of vitamins K2 against clinical isolates of quinolone-resistant and methicillin-resistant Staphylococcus aureus (QR-MRSA) with different multi-locus sequence types (MLST), SCCmec, and spa types

Antibiotic resistance	Pearson (r) and χ2 (p) correlations
	K₂ MICs		norA Expr		grlA Expr		grlB Expr		gyrA Expr		gyrB Expr		Clinical samples
	r	p	r	p	r	p	r	p	r	p	r	p	r	p
GEN	−0.497	0.050	0.362	< 0.001	−0.361	0.012	−0.345	0.016	0.793	≤ 0.001	−3.794	< 0.001	−3.794	< 0.001
E	0.491	0.053	0.535	0.002	0.082	0.579	0.037	0.802	0.746	≤ 0.001	0.454	0.0029	−0.445	0.026
TET	0.556	0.025	0.450	< 0.001	−0.002	0.992	0.040	0.786	0.188	0.200	0.373	0.029	0.047	0.502
CIP	0.561	0.024	0.435	0.015	−0.316	0.029	0.419	0.003	0.245	0.094	0.115	0.0149	0.040	0.786
GAT	0.769	0.001	0.337	0.254	0.327	0.023	0.485	≤ 0.001	0.019	5.272	0.055	0.079	0.319	0.043
NOR	0.642	0.007	0.540	< 0.001	−0.239	0.102	0.163	0.269	0.296	−0.102	0.195	0.015	0.575	0.055
OFL	0.682	0.004	0.234	0.710	−0.199	0.176	0.217	0.138	0.007	−0.461	0.173	0.019	0.263	0.269
RIF	−0.431	0.096	0.336	0.195	−0.062	0.675	−0.301	0.038	0.632	0.135	0.551	0.003	0.217	0.138
PEN	0.476	0.062	0.421	0.074	0.351	0.014	0.401	0.005	0.0551	−0.072	0.188	0.030	−0.301	0.044
CLI	0.443	0.086	0.317	0.402	−0.361	0.012	−0.345	0.016	0.793	≤ 0.001	0.500	0.006	−0.401	0.015
MRSA strains	0.449	0.081	0.344	0.0019	0.280	0.040	0.037	0.802	0.246	0.007	0.235	0.046	−0.345	0.016
MDR strains	0.794	0.001	0.498	< 0.001	−0.622	0.009	0.040	0.786	0.177	0.005	0.242	0.007	−0.037	0.002
XDR strains	−0.728	0.001	0.384	< 0.001	−0.316	0.029	0.419	0.003	−0.542	0.064	0.923	0.066	0.040	0.086
SCCmce types
SCCmecI	−0.522	0.038	−0.522	0.038	−0.369	0.025	−0.288	0.039	−0.679	0.010	0.324	0.910	−0.445	0.026
SCCmecII	0.065	0.810	−0.816	< 0.001	−0.217	0.138	−0.500	0.001	−0.399	0.044	0.321	0.805	0.330	0.012
SCCmecIII	−0.481	0.060	−0.481	0.060	−0.390	0.042	−0.235	0.039	−0.062	0.006	0.521	0.094	0.040	0.786
SCCmecIV	0.598	0.014	0.598	0.014	0.401	0.065	−0.242	0.037	0.351	0.055	0.317	0.402	−0.419	0.003
SCCmecV	0.722	0.002	0.722	0.002	−0.345	0.016	0.629	0.088	−0.361	0.049	0.334	0.810	−0.485	0.004
spa types	0.344	0.019	−0.223	0.406	−0.249	0.352	−0.398	0.127	0.077	0.777	0.056	0.837	0.554	0.550
MLST	0.509	0.056	0.447	0.040	−0.390	0.022	−0.445	0.036	0.493	0.033	0.378	0.076	−0.665	0.001
K₂ MICs	–	–	−0.622	< 0.001	−0.490	< 0.001	0.566	< 0.001	−0.542	0.064	0.579	0.003	−0.744	< 0.001
CIP MICs	–	–	−0.530	< 0.001	−0.629	< 0.001	−0.219	< 0.001	−0.711	0.001	−0.398	0.001	−0.621	< 0.001
Clinical samples
Blood	−0.442	0.044	−0.522	0.038	0.272	0.019	−0.794	< 0.001	0.642	0.007	0.115	0.672	–	–
Urine	−0.716	0.051	−0.816	< 0.001	−0.102	0.029	0.154	0.094	−0.117	0.667	−0.475	0.063	–	–
Burn wound	−0.288	0.039	−0.481	0.060	−0.461	0.007	0.353	0.022	−0.267	0.017	−0.173	0.521	–	–
Pus swab	−0.598	0.024	0.598	0.014	0.135	0.632	0.005	0.849	0.195	0.469	−0.398	0.126	–	–
Catheter	−0.722	0.032	0.722	0.002	−0.072	0.055	0.155	0.069	0.160	0.555	−0.522	0.038	–	–

GEN gentamycin, ER erythromycin, TET tetracycline, CIP ciprofloxacin, GAT gatifloxacin, NOR norfloxacin, LIZ linezolid, RIF rifampin, OFL ofloxacin, P penicillin, CL clindamycin, MRSA methicillin-resistant Staphylococcus aureus, MDR multidrug-resistant, XDR extreme drug resistance, MLST multi-locus sequence typing, Expr expression level of gene
r: indicates the association between a dependent variable and independent variables by a linear regression model. The significance level was set at 0.05
p: indicates the significance of the χ² test. Variables were considered normal when p ≤ 0.05

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