Table 1 Demographic, clinical, laboratory features
Variable | Total (n = 190) | Mild (n = 24) | Moderate-to-severed (n = 166) | P-value | Training cohort (n = 134) | Validation cohort (n = 56) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Mild (n = 19) | Moderate-to-severe (n = 115) | P | Mild (n = 5) | Moderate-to-severe (n = 51) | P | |||||
Birth weight (mean \(\pm\) sd) | 3.3 \(\pm\) 0.5 | 3.2 \(\pm 0.5\) | 3.3 \(\pm 0.5\) | 0.482 | 3.2 \(\pm\) 0.6 | 3.3 \(\pm 0.5\) | 0.634 | 3.3 \(\pm\) 0.2 | 3.4 \(\pm 0.5\) | 0.657 |
Gestational time, week (mean \(\pm\) sd) | 39.4 \(\pm\) 1.1 | 39.2 \(\pm 1.1\) | 39.5 \(\pm 1.1\) | 0.207 | 39.0 \(\pm 1.1\) | 39.5 \(\pm 1.1\) | 0.778 | 39.9 \(\pm 0.8\) | 39.4 \(\pm 1.0\) | 0.351 |
Age, day (mean \(\pm\) sd) | 8.5 \(\pm\) 4.7 | \(7.9\pm 2.1\) | 8.6 \(\pm 4.9\) | 0.5069 | \(8.4\pm 2.1\) | 8.3 \(\pm 4.8\) | 0.936 | \(6.0\pm 1.2\) | \(9.5\pm 5.3\) | 0.182 |
Gender, n (%) | ||||||||||
F | 50 (26.3%) | 3 (12.5%) | 47 (28.3%) | 2 (10.5%) | 34 (29.6%) | 1 (20.0%) | 13 (25.5%) | |||
M | 140 (73.7%) | 21 (87.5%) | 119 (71.7%) | 0.162 | 17 (89.5%) | 81 (70.4) | 0.146 | 4 (80.0%) | 38 (74.5%) | 1.000 |
ALT (mean \(\pm\) sd) | 53.1 \(\pm\) 71.7 | 52.6 \(\pm 85.6\) | 53.2 \(\pm\) 69.7 | 0.968 | 59.7 \(\pm 95.2\) | 51.8 \(\pm 59.7\) | 0.625 | 25.2 \(\pm 13.0\) | 56.3 \(\pm 88.9\) | 0.438 |
AST (mean \(\pm\) sd) | 117.6 \(\pm\) 106.6 | \(85.4\pm 70.7\) | 122.3 \(\pm 110.2\) | 0.112 | 86.7 \(\pm 78.1\) | 125.5 \(\pm 112.6\) | 0.159 | 77.0 \(\pm\) 33.9 | 115.1 \(\pm 105.5\) | 0.425 |
Urea nitrogen (mean \(\pm\) sd) | 5.3 \(\pm\) 3.2 | 4.0 \(\pm 1.8\) | 5.5 \(\pm 3.3\) | 0.031 | 3.9 \(\pm 1.8\) | 5.6 \(\pm 3.6\) | 0.042 | 4.3 \(\pm 1.8\) | 5.2 \(\pm 2.6\) | 0.476 |
Creatinine (mean \(\pm\) sd) | 68.1 \(\pm\) 36.0 | 57.5 \(\pm 29.8\) | 69.7 \(\pm 36.7\) | 0.120 | 53.9 \(\pm\) 30.0 | 71.2 \(\pm\) 37.6 | 0.057 | 71.2 \(\pm 25.7\) | 66.3 \(\pm 34.5\) | 0.760 |
CK-MB (mean \(\pm\) sd) | 129.4 \(\pm\) 211.3 | 119.1 \(\pm 202.3\) | 130.8 \(\pm 213.3\) | 0.800 | 125.4 \(\pm\) 225.2 | 132.4 \(\pm 176.1\) | 0.878 | 95.3 \(\pm 78.7\) | 127.3 \(\pm 281.4\) | 0.801 |
Procalcitonin (mean \(\pm\) sd) | 8.3 \(\pm\) 16.9 | 6.0 \(\pm 17.7\) | 8.6 \(\pm 16.9\) | 0.478 | \(2.7\pm 3.6\) | 9.8 \(\pm 19.1\) | 0.1.06 | 18.5 \(\pm 38.7\) | \(6.0\pm 9.9\) | 0.059 |
Lactic acid (mean \(\pm\) sd) | 5.8 \(\pm 3.1\) | 5.4 \(\pm 2.0\) | 5.9 \(\pm 3.2\) | 0.453 | \(5.4\pm 1.9\) | 6.3 \(\pm 3.5\) | 0.270 | 5.3 \(\pm 2.6\) | 4.9 \(\pm 2.4\) | 0.774 |
D-dimer (mean \(\pm\) sd) | \(4.6\pm 7.6\) | 2.9 \(\pm 2.1\) | 4.8 \(\pm 8.1\) | 0.243 | 2.7 \(\pm 1.6\) | 4.8 \(\pm 7.9\) | 0.244 | 3.7 \(\pm 3.7\) | 4.9 \(\pm 8.6\) | 0.756 |
CO2 (mean \(\pm\) sd) | \(37.1\pm\) 13.8 | 37.8 \(\pm 12.5\) | 37.0 \(\pm 14.0\) | 0.786 | 37.3 \(\pm 13.4\) | 37.4 \(\pm 14.8\) | 0.963 | 39.8 \(\pm 9.3\) | 35.9 \(\pm 12.0\) | 0.490 |
PO2 (mean \(\pm\) sd) | 79.6 \(\pm\) 39.2 | 68.3 \(\pm 18.2\) | 81.2 \(\pm 41.2\) | 0.133 | \(66.0\pm 18.7\) | 76.5 \(\pm 27.1\) | 0.106 | 77.2 \(\pm 14.1\) | 91.8 \(\pm 61.3\) | 0.600 |
HCO3-ion (mean \(\pm\) sd) | 21.0 \(\pm 9.1\) | 25.4 \(\pm 5.3\) | 20.3 \(\pm 9.4\) | 0.001 | 25.5 \(\pm 4.7\) | 20.9 \(\pm 9.8\) | 0.043 | 25.0 \(\pm 8.1\) | 19.1 \(\pm 8.3\) | 0.130 |
PH (mean \(\pm\) sd) | 7.3 \(\pm\) 0.2 | 7.4 \(\pm 0.1\) | 7.3 \(\pm 0.2\) | 0.003 | 7.4 \(\pm 0.1\) | 7.3 \(\pm 0.2\) | 0.005 | 7.4 \(\pm 0.1\) | 7.3 \(\pm 0.2\) | 0.321 |
BE (mean \(\pm\) sd) | -4.3 \(\pm 9.0\) | 1.5 \(\pm 5.1\) | -5.2 \(\pm 9.1\) | \(<0.001\) | 1.7 \(\pm 4.6\) | -4.8 \(\pm 8.6\) | 0.002 | 0.70 \(\pm 7.4\) | -6.0 \(\pm 9.6\) | 0.132 |