Table 1 Clinical characteristics

No. of patients

696

362 (52)

207 (29.7)

127 (18.2)

Age (median (IQR))

60 (51–69)

59 (49–67)

61 (52–71)

65 (54–74)

< 0.001

 Mean

59.5

57.7

60.8

62.6

Sex

< 0.001

 Female

526 (75.6)

291 (80.4)

159 (76.8)

76 (59.8)

 Male

170 (24.4)

71 (19.6)

48 (23.2)

51 (40.2)

No pre-existing disease

183 (26.3)

99 (27.3)

47 (22.7)

37 (29.1)

0.364

 NK

2 (0.3)

1 (0.3)

1 (0.5)

–

Pre-existing disease

 Arterial hypertension

300 (43.1)

151 (41.7)

95 (45.9)

54 (42.5)

0.649

 NK

2 (0.3)

2 (0.5)

–

–

 Heart insufficiency/arrhythmia

73 (10.5)

35 (9.7)

23 (11.1)

15 (11.8)

0.740

 NK

2 (0.3)

2 (0.5)

–

–

 Heart anomaly

22 (3.2)

7 (1.9)

11 (5.3)

4 (3.1)

NK*

 NK

2 (0.3)

2 (0.5)

–

–

 COPD/asthma

47 (6.8)

18 (5)

18 (8.7)

11 (8.7)

NK*

 NK

2 (0.3)

2 (0.5)

–

–

 Diabetes mellitus

70 (10.1)

29 (8)

27 (13)

14 (11)

0.144

 NK

2 (0.3)

2 (0.5)

–

–

 Renal insufficiency

21 (3)

7 (1.9)

9 (4.3)

5 (3.9)

NK*

 NK

2 (0.3)

2 (0.5)

–

–

 Cancers

106 (15.2)

53 (14.6)

34 (16.4)

19 (15)

0.864

 NK

2 (0.3)

2 (0.5)

–

–

 Endocrine disorder

115 (16.5)

59 (16.3)

38 (18.4)

18 (14.2)

0.630

 NK

2 (0.3)

2 (0.5)

–

–

 Depression

31 (4.5)

18 (5)

9 (4.3)

4 (3.1)

NK*

 NK

1 (0.1)

1 (0.3)

–

–

 Other comorbidities

274 (39.4)

143 (39.5)

87 (42)

44 (34.6)

0.402

 NK

2 (0.3)

2 (0.5)

–

–

 Neurosurgical interventions

31 (4.5)

14 (3.9)

14 (6.8)

3 (2.4)

NK*

 NK

1 (0.1)

1 (0.3)

–

–

ASA score

0.043^§

 1

99 (14.2)

58 (16)

25 (12.1)

16 (12.6)

 2

397 (57)

218 (60.2)

113 (54.6)

66 (52)

 3

180 (25.8)

79 (21.8)

59 (28.5)

42 (33.1)

 4

16 (2.3)

6 (1.7)

7 (3.4)

3 (2.4)

 5

2 (0.3)

–

2 (1)

–

 NK

2 (0.3)

1 (0.3)

1 (0.5)

–