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Table 3 Preoperative clinical condition, surgical and histopathological results

From: Impact of peritumoral brain edema on pre- and postoperative clinical conditions and on long-term outcomes in patients with intracranial meningiomas

 

All patients

No. (%)

No edema

No. (%)

Edema < 51.95 cm3

No. (%)

Edema ≥ 51.95 cm3

No. (%)

p value

Symptomatic meningiomas

627 (90.1%)

314 (86.7%)

188 (90.8%)

125 (98.4%)

< 0.001

Preoperative symptoms and neurological deficits

     

 Headache

200 (28.7)

98 (27.1)

57 (27.5)

45 (35.4)

0.188

 Cognitive deficits

91 (13.1)

15 (4.1)

32 (15.5)

44 (34.6)

< 0.001

 Palsy

60 (8.6)

15 (4.1)

27 (13)

18 (14.2)

< 0.001

 Sensitivity disorder

43 (6.3)

21 (5.8)

17 (8.2)

5 (3.9)

NK*

 Cranial nerve disorder

211 (30.3)

144 (39.8)

50 (24.2)

17 (13.4)

< 0.001

 Olfactory dysfunction

21 (3)

3 (0.8)

9 (4.3)

9 (7.1)

NK*

 Seizure

92 (13.2)

23 (6.4)

41 (19.8)

28 (22)

< 0.001

 Aphasia

42 (6)

7 (1.9)

20 (9.7)

15 (11.8)

NK*

 Gait disorder and dizziness

132 (19)

65 (18)

44 (21.3)

23 (18.1)

0.621

 Hormonal disorder

5 (0.7)

1 (0.3)

4 (1.9)

–

NK*

 Visible swelling

31 (4.5)

28 (7.7)

2 (1)

1 (0.8)

NK*

Tumor resection (Simpson Grade)

    

0.025§

 1

359 (51.6)

170 (47)

118 (57)

71 (55.9)

 

 2

191 (27.4)

98 (27.1)

60 (29)

33 (26)

 

 3

25 (3.6)

18 (5)

5 (2.4)

2 (1.6)

 

 4

80 (11.5)

51 (14.1)

15 (7.2)

14 (11)

 

 5

7 (1)

6 (1.7)

1 (0.5)

–

 

 NK

34 (4.9)

19 (5.2)

8 (3.9)

7 (5.5)

 

Histology

     

 Meningothelial

333 (47.8)

186 (51.4)

83 (40.1)

64 (50.4)

0.026

 Transitional

125 (18)

60 (16.6)

43 (20.8)

22 (17.3)

0.44

 Fibrous

88 (12.6)

56 (15.5)

30 (14.5)

2 (1.6)

< 0.001

 Psammomatous

14 (2)

9 (2.5)

4 (1.9)

1 (0.8)

NK*

 Angiomatous

11 (1.6)

4 (1.1)

2 (1)

5 (3.9)

NK*

 Secretory

22 (3.2)

10 (2.8)

6 (2.9)

6 (4.7)

NK*

 Microcystic

10 (1.4)

2 (0.6)

3 (1.4)

5 (3.9)

NK*

 Choroidal

2 (0.3)

–

1 (0.5)

1 (0.8)

NK*

 Atypical

57 (8.2)

18 (5)

22 (10.6)

17 (13.4)

0.004

 Papillary

1 (0.1)

–

–

1 (0.8)

NK*

 Anaplastic

8 (1.1)

2 (0.6)

5 (2.4)

1 (0.8)

NK*

 NK

25 (3.6)

15 (4.1)

8 (3.9)

2 (1.6)

 

WHO Classification

    

< 0.001$

 1

621 (89.2)

338 (93.4)

178 (86)

105 (82.7)

 

 2

59 (8.5)

18 (5)

22 (10.6)

19 (15)

 

 3

10 (1.4)

3 (0.8)

5 (2.4)

2 (1.6)

 

 NK

6 (0.9)

3 (0.8)

2 (1)

1 (0.8)

 

Ki-67 index (median (IQR))

3.0 (2.0–5.0)

3.0 (2.0–5.0)

5.0 (2.0–5.0)

5.0 (3.0–10.0)

< 0.001

 (Mean)

5.9

5.1

6.6

6.9

 

 NK (no. of cases)

197 (28.3)

121 (33.4)

42 (20.3)

34 (26.8)

 
  1. Variables with significant differences between the three groups are highlighted in bold
  2. No. number, NK not known, IQR interquartile range, p value p value for differences between the three groups (without and with edema) (Fisher’s exact test for categorical variables, Kruskal–Wallis test for continuous variables)
  3. *Dichotomous variables with less than 50 occurrences in one of the categories in all patients were not tested for differences between the three groups (without and with edema)
  4. §Simpson grades IV and V were merged for Fisher’s exact test
  5. $WHO classes 2 and 3 were merged for Fisher’s exact test
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European Journal of Medical Research

ISSN: 2047-783X

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