Impact of peritumoral brain edema on pre- and postoperative clinical conditions and on long-term outcomes in patients with intracranial meningiomas

Table 4 Multiple logistic regression analyses for preoperative cognitive deficits, seizure, palsy and cranial nerve disorder

	Odds ratio	95% Confidence interval	p value
Cognitive deficits
No edema	Reference
Edema < 51.95 cm³	3.21	1.65–6.22	< 0.001
Edema ≥ 51.95 cm³	9.61	5.01–18.41	< 0.001
ASA Score 3, 4	Reference
ASA Score 1	0.43	0.18–1.01	0.05
ASA Score 2	0.44	0.26–0.76	0.002
KPS preop	0.97	0.94–0.98	0.001
Without significance: age, sex, tumor sit and tumor volume
Seizure
No edema	Reference
Edema < 51.95 cm³	3.08	1.66–5.68	< 0.001
Edema ≥ 51.95 cm³	3.82	1.89–7.71	< 0.001
Tumor site: convexity	Reference
Falx/parasagittal	1.11	0.60–2.05	0.73
Tuberculum sellae	0.13	0.01–1.04	0.05
Other	0.42	0.24–0.74	0.002
Tumor volume in cm³	0.98	0.98–0.99	0.01
KPS preop	0.96	0.95–0.98	0.001
Without significance: age, sex and ASA score
Palsy
Age	1.03	1.00–1.05	0.005
Tumor site: convexity	Reference
Falx/parasagittal	0.89	0.40–1.95	0.77
Other	0.45	0.23–0.88	0.01
Tumor volume in cm³	1.00	1.00–1.01	0.001
KPS preop	0.94912	0.92822–0.97049	< 0.001
Without significance: edema, sex and ASA score
Cranial nerve disorder
No edema	Reference
Edema < 51.95 cm³	0.68	0.43–1.05	0.08
Edema ≥ 51.95 cm³	0.27	0.15–0.49	< 0.001
Age	0.97	0.96–0.98	< 0.001
Tumor site: convexity	Reference
Falx/parasagittal	1.62	0.81–3.24	0.16
Tuberculum sellae	20.48	9.11–46.04	< 0.001
Other	5.30	3.17–8.84	< 0.001
KPS preop	0.96	0.95–0.98	< 0.001
Without significance: sex, ASA score and tumor volume

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