| ALC (pre-NAC) | NLR (pre-NAC) | ALC (post-NAC) | NLR (post-NAC) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Low | High | P value | Low | High | P value | Low | High | P value | Low | High | P value | |
All breast cancer (n = 327) | ||||||||||||
TC (preNAC) | Â | Â | 0.638 | Â | Â | 0.479 | Â | Â | 0.564 | Â | Â | 0.978 |
 Normal | 82 (56.9%) | 79 (54.1%) |  | 76 (53.2%) | 85 (57.8%) |  | 145 (56.2%) | 15 (50.0%) |  | 59 (55.7%) | 101 (55.5%) |  |
 High | 62 (43.1%) | 67 (45.9%) |  | 67 (46.8%) | 62 (42.2%) |  | 113 (43.8%) | 15 (50.0%) |  | 47 (44.3%) | 81 (44.5%) |  |
TG (preNAC) | Â | Â | 0.249 | Â | Â | 0.886 | Â | Â | 0.101 | Â | Â | 0.655 |
 Normal | 117 (81.8%) | 110 (75.9%) |  | 112 (79.4%) | 115 (78.2%) |  | 205 (80.1%) | 20 (66.7%) |  | 81 (77.1%) | 144 (79.6%) |  |
 High | 26 (18.2%) | 35 (24.1%) |  | 29 (20.6%) | 32 (21.8%) |  | 51 (19.9%) | 10 (33.3%) |  | 24 (22.9%) | 37 (20.4%) |  |
TC (postNAC) | Â | Â | 0.388 | Â | Â | 0.219 | Â | Â | 0.292 | Â | Â | 0.163 |
 Normal | 60 (47.6%) | 59 (41.8%) |  | 60 (41.1%) | 59 (48.8%) |  | 105 (43.8%) | 14 (56.0%) |  | 51 (50.5%) | 68 (41.5%) |  |
 High | 66 (52.4%) | 82 (58.2%) |  | 86 (58.9%) | 62 (51.2%) |  | 135 (56.2%) | 11 (44.0%) |  | 50 (49.5%) | 96 (58.5%) |  |
TG (postNAC) | Â | Â | 0.001 | Â | Â | 0.164 | Â | Â | 0.803 | Â | Â | 0.974 |
 Normal | 81 (68.6%) | 63 (46.7%) |  | 73 (52.9%) | 71 (61.7%) |  | 129 (56.8%) | 13 (54.2%) |  | 55 (56.7%) | 87 (56.5%) |  |
 High | 37 (31.4%) | 72 (53.3%) |  | 65 (47.1%) | 44 (38.3%) |  | 98 (43.2%) | 11 (45.8%) |  | 42 (43.3%) | 67 (43.5%) |  |
Luminal (n = 108) | ||||||||||||
TC (preNAC) | Â | Â | 0.54 | Â | Â | 0.838 | Â | Â | 0.728 | Â | Â | 0.665 |
 Normal | 25 (58.1%) | 27 (50.9%) |  | 28 (52.8%) | 24 (55.8%) |  | 48 (55.2%) | 4 (44.4%) |  | 16 (50.0%) | 36 (56.3%) |  |
 High | 18 (41.9%) | 26 (49.1%) |  | 25 (47.2%) | 19 (44.2%) |  | 39 (44.8%) | 5 (55.6%) |  | 16 (50.0%) | 28 (43.7%) |  |
TG (preNAC) | Â | Â | 0.801 | Â | Â | 0.801 | Â | Â | 0.915 | Â | Â | 0.064 |
 Normal | 35 (81.4%) | 41 (77.4%) |  | 41 (77.4%) | 35 (81.4%) |  | 69 (79.3%) | 7 (77.8%) |  | 29 (90.6%) | 47 (73.4%) |  |
 High | 8 (18.6%) | 12 (22.6%) |  | 12 (22.6%) | 8 (18.6%) |  | 18 (20.7%) | 2 (22.2%) |  | 3 (9.4%) | 17 (26.6%) |  |
TC (postNAC) | Â | Â | 0.853 | Â | Â | 0.667 | Â | Â | 0.926 | Â | Â | 0.38 |
 Normal | 15 (36.6%) | 20 (38.5%) |  | 20 (35.7%) | 15 (40.5%) |  | 31 (37.8%) | 4 (36.4%) |  | 16 (44.4%) | 19 (33.3%) |  |
 High | 26 (63.4%) | 32 (61.5%) |  | 36 (64.3%) | 22 (59.5%) |  | 51 (62.2%) | 7 (63.6%) |  | 20 (55.6%) | 38 (66.7%) |  |
TG (postNAC) | Â | Â | 0.397 | Â | Â | 0.386 | Â | Â | 0.515 | Â | Â | 0.661 |
 Normal | 25 (64.1%) | 28 (54.9%) |  | 34 (63.0%) | 19 (52.8%) |  | 45 (57.0%) | 8 (72.7%) |  | 22 (62.9%) | 31 (56.4%) |  |
 High | 14 (35.9%) | 23 (45.1%) |  | 20 (37.0%) | 17 (47.2%) |  | 34 (43.0%) | 3 (27.3%) |  | 13 (37.1%) | 24 (43.6%) |  |
Luminal-HER (n = 42) | ||||||||||||
TC (preNAC) | Â | Â | 0.176 | Â | Â | 0.491 | Â | Â | 0.135 | Â | Â | 0.774 |
 Normal | 13 (72.2%) | 8 (47.1%) |  | 10 (52.6%) | 11 (68.8%) |  | 19 (65.5%) | 1 (20.0%) |  | 9 (56.3%) | 11 (61.1%) |  |
 High | 5 (27.8%) | 9 (52.9%) |  | 9 (47.4%) | 5 (31.2%) |  | 10 (34.5%) | 4 (80.0%) |  | 7 (43.7%) | 7 (38.9%) |  |
TG (preNAC) | Â | Â | 0.695 | Â | Â | 0.114 | Â | Â | 0.868 | Â | Â | 0.7 |
 Normal | 14 (73.7%) | 14 (82.4%) |  | 17 (89.5%) | 11 (64.7%) |  | 23 (76.7%) | 4 (80.0%) |  | 13 (81.3%) | 14 (73.7%) |  |
 High | 5 (26.3%) | 3 (17.6%) |  | 2 (10.5%) | 6 (35.3%) |  | 7 (23.3%) | 1 (20.0%) |  | 3 (18.7%) | 5 (26.3%) |  |
TC (postNAC) | Â | Â | 0.462 | Â | Â | 0.715 | Â | Â | 0.96 | Â | Â | 0.837 |
 Normal | 10 (58.8%) | 5 (38.5%) |  | 8 (57.1%) | 7 (43.8%) |  | 14 (51.9%) | 1 (50.0%) |  | 7 (53.9%) | 8 (50.0%) |  |
 High | 7 (41.2%) | 8 (61.5%) |  | 6 (42.9%) | 9 (56.2%) |  | 13 (48.1%) | 1 (50.0%) |  | 6 (46.1%) | 8 (50.0%) |  |
TG (postNAC) | Â | Â | 0.274 | Â | Â | 0.897 | Â | Â | 0.206 | Â | Â | 0.705 |
 Normal | 11 (64.7%) | 5 (41.7%) |  | 7 (53.9%) | 9 (56.3%) |  | 15 (57.7%) | 0 (0.00%) |  | 6 (46.2%) | 9 (60.0%) |  |
 High | 6 (35.3%) | 7 (58.3%) |  | 6 (46.1%) | 7 (43.7%) |  | 11 (42.3%) | 2 (100.0%) |  | 7 (53.8%) | 6 (40.0%) |  |
HER2-enriched (n = 72) | ||||||||||||
TC (preNAC) | Â | Â | 0.955 | Â | Â | 0.935 | Â | Â | 0.738 | Â | Â | 0.935 |
 Normal | 20 (60.6%) | 19 (61.3%) |  | 16 (61.5%) | 23 (60.5%) |  | 33 (62.3%) | 6 (54.6%) |  | 16 (61.5%) | 23 (60.5%) |  |
 High | 13 (39.4%) | 12 (38.7%) |  | 10 (38.5%) | 15 (39.5%) |  | 20 (37.7%) | 5 (45.4%) |  | 10 (38.5%) | 15 (39.5%) |  |
TG (preNAC) | Â | Â | 0.363 | Â | Â | 0.539 | Â | Â | 0.046 | Â | Â | 0.349 |
 Normal | 26 (83.9%) | 22 (73.3%) |  | 20 (83.3%) | 28 (75.7%) |  | 42 (84.0%) | 6 (54.6%) |  | 18 (72.0%) | 30 (83.3%) |  |
 High | 5 (16.1%) | 8 (26.7%) |  | 4 (16.7%) | 9 (24.3%) |  | 8 (16.0%) | 5 (45.4%) |  | 7 (28.0%) | 6 (16.7%) |  |
TC (postNAC) | Â | Â | 0.593 | Â | Â | 0.787 | Â | Â | 0.697 | Â | Â | 0.267 |
 Normal | 16 (66.7%) | 20 (58.8%) |  | 17 (58.6%) | 19 (65.5%) |  | 30 (60.0%) | 6 (75.0%) |  | 16 (72.7%) | 20 (55.6%) |  |
 High | 8 (33.3%) | 14 (41.2%) |  | 12 (41.4%) | 10 (34.5%) |  | 20 (40.0%) | 2 (25.0%) |  | 6 (27.3%) | 16 (44.4%) |  |
TG (postNAC) | Â | Â | 0.021 | Â | Â | 0.264 | Â | Â | 0.766 | Â | Â | 0.779 |
 Normal | 18 (81.8%) | 15 (48.4%) |  | 14 (53.9%) | 19 (70.4%) |  | 29 (63.0%) | 4 (57.1%) |  | 13 (65.0%) | 20 (60.6%) |  |
 High | 4 (18.2%) | 16 (51.6%) |  | 12 (46.1%) | 8 (29.6%) |  | 17 (37.0%) | 3 (42.9%) |  | 7 (35.0%) | 13 (39.4%) |  |
TNBC (n = 105) | ||||||||||||
TC (preNAC) | Â | Â | 0.539 | Â | Â | 0.683 | Â | Â | 0.364 | Â | Â | 0.664 |
 Normal | 24 (48.0%) | 25 (55.6%) |  | 22 (48.9%) | 27 (54.0%) |  | 45 (50.6%) | 4 (80.0%) |  | 18 (56.3%) | 31 (50.0%) |  |
 High | 26 (52.0%) | 20 (44.4%) |  | 23 (51.1%) | 23 (46.0%) |  | 44 (49.4%) | 1 (20.0%) |  | 14 (43.7%) | 31 (50.0%) |  |
TG (preNAC) | Â | Â | 0.22 | Â | Â | 0.462 | Â | Â | 0.287 | Â | Â | 0.034 |
 Normal | 42 (84.0%) | 33 (73.3%) |  | 34 (75.6%) | 41 (82.0%) |  | 71 (79.8%) | 3 (60.0%) |  | 21 (65.6%) | 53 (85.5%) |  |
 High | 8 (16.0%) | 12 (26.7%) |  | 11 (24.4%) | 9 (18.0%) |  | 18 (20.2%) | 2 (40.0%) |  | 11 (34.4%) | 9 (14.5%) |  |
TC (postNAC) | Â | Â | 0.382 | Â | Â | 0.19 | Â | Â | 0.294 | Â | Â | 0.87 |
 Normal | 19 (43.2%) | 14 (33.3%) |  | 15 (31.9%) | 18 (46.2%) |  | 30 (37.0%) | 3 (75.0%) |  | 12 (40.0%) | 21 (38.2%) |  |
 High | 25 (56.8%) | 28 (66.7%) |  | 32 (68.1%) | 21 (53.8%) |  | 51 (63.0%) | 1 (25.0%) |  | 18 (60.0%) | 34 (61.8%) |  |
TG (postNAC) | Â | Â | 0.008 | Â | Â | 0.025 | Â | Â | 0.353 | Â | Â | 0.817 |
 Normal | 27 (67.5%) | 15 (36.6%) |  | 18 (40.0%) | 24 (66.7%) | 40 (52.6%) | 1 (25.0%) | 14 (48.3%) | 27 (52.9%) |  | ||
 High | 13 (32.5%) | 26 (63.4%) |  | 27 (60.0%) | 12 (33.3%) | 36 (47.4%) | 3 (75.0%) | 15 (51.7%) | 24 (47.1%) |  |