A study on endovascular treatment alone and bridging treatment for acute ischemic stroke

Table 4 Functional and safety outcomes of different subgroups

	under4.5 h			4.5–6 h			6–8 h			8–10 h
	EVT (n = 24)	IV+EVT (n = 31)	P	EVT (n = 10)	IV+EVT (n = 15)	P	EVT (n = 25)	IV+EVT (n = 11)	P	EVT (n = 19)	IV + EVT (n = 5)	P
Primary outcome
mRS at 90 d Median score (IQR)	2 (0–6)	2 (0–6)		2 (0–6)	2 (0–5)		2 (0–6)	3 (0–6)		2 (0–6)	2 (1–3)
Secondary outcomes
mRS 0–2 at 90 d—no./total no. (%)†	9 (37.5)	6 (19.4)	0.74	3 (30.0)	13 (86.7)	0.47	8 (32.0)	6 (54.5)	0.18	9 (47.4)	2 (40.0)	0.59
Change in NIHSS score at 24 h Median (IQR)‡	3 (− 6–24)	0 (− 18–16)	0.06	0 (− 30–21)	0 (− 30–21)	0.58	5 (− 3–19)	0 (− 18–6)	0.01	0 (− 14–14)	5(-6–5)	0.14
Change in NIHSS score at 7d Median (IQR)‡	8 (− 4–22)	4 (− 24–23)	0.45	2 (− 30–21)	4 (− 30–21)	0.80	9 (− 3–26)	2 (0–10)	0.02	3 (− 28–14)	6 (− 8–9)	NA
mTICI score of 2b or 3—no./total no. (%)	23 (95.8)	23 (74.2)	0.03	8 (80.0)	12 (80.0)	0.70	22 (88.0)	9 (81.8)	0.25	12 (63.2)	5 (100)	0.15
Safety outcomes
Mortality at 90 d—no/total no. (%)	6 (25.0)	6 (19.4)	0.62	2 (20.0)	2 (13.3)	0.53	1 (4.0)	4 (36.4)	0.02	5 (26.3)	0	NA
Hemorrhage—no/total no. (%)	1 (4.2)	2 (6.5)	0.60	0	2 (13.3)	0.35	1 (4.0)	2 (18.2)	0.22	0	1 (20.0)	NA

Favorable reperfusion was defined as reperfusion of at least 50% and a modified Thrombolysis in Cerebral Infarction score of 2b (50–99% reperfusion) or 3 (complete reperfusion), as assessed with the use of DSA
^*The MRS of functional disability ranges from 0 (no symptoms) to 6 (death)
^†Functional independence was defined as a score of 0, 1, or 2 on the MRS
^‡Change in NIHSS score was defined as a difference value of the NIHSS score between admission and postoperation at 24 h. NIHSS scores at 24 h or in 7 days

ISSN: 2047-783X