Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy

Saadh, Mohamed J.; Mikhailova, Maria V.; Rasoolzadegan, Soheil; Falaki, Mojgan; Akhavanfar, Roozbeh; Gonzáles, José Luis Arias; Rigi, Amir; Kiasari, Bahman Abedi

doi:10.1186/s40001-023-01008-7

Table 1 Naive MSCs transplantation in IBD animal models

From: Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy

Diseases	Source	Model	Results	Refs.
TNBS-induced colitis	UC	BALB/c mice	Reducing colitis by suppression of the Th1/17 activation	[227]
DSS-induced colitis	BM	C57BL/6 mice	Reducing the numbers of neutrophils in colon tissue and metalloproteinase activity in the mucosa while promoting the Tregs population	[85]
DSS-induced colitis	BM	BALB/c mice	Attenuation of TNF-α and IL-1β levels in both the inflamed colon and serum	[68]
DSS and TNBS-induced colitis	UC	BALB/c mice	Amelioration of colitis by up-regulating NOD2/COX2 signaling pathways	[69]
TNBS-induced colitis	Placenta	BALB/c mice	Promoting the therapeutic potential of MSCs by improving the PGE2-mediated M2 macrophage polarization by combination therapy with chitosan-based hydrogel	[228]
TNBS-induced colitis	AT BM	Wistar rats	Promoting VEGF and TGF-β levels while attenuating TNF-α and IL-1β	[229]
TNBS-induced colitis	BM	Wistar rats	MSCs’ partial differentiation into IECs and secreting VEGF and TGF-β1	[230]
DSS-induced colitis	BM	C57BL/6 mice	Recruiting M2 macrophage to reduce colitis severity by secretion of the TGFβ1	[231]
AOM and DSS-induced colitis	UC	C57BL/6 mice	Enhancing Treg cells differentiation by MSCs-secreted TGF-β	[232]
DSS-induced colitis	AT	C57BL/6 mice	Stimulation of the polarization of the M2 macrophages by MScs-secreted TSG-6	[233]
DSS-induced colitis	BM	C57BL/6 mice	Suppression of dendritic cells (DCs) activation by the release of galectin 3	[58]
AOM and DSS-induced colitis	BM	C57BL/6 mice	Amelioration of histological damage along with reducing TNF-α, IL-1β, and IL-6 levels and down-regulation of STAT3 phosphorylation in colon tissue	[234]
DSS-induced colitis	UC	C57BL/6 mice	Eliciting anti-inflammatory response in colon tissue by improving Treg/Th17 cells ratio in the spleen and mesenteric lymph nodes	[235]
DSS-induced colitis	BM	C57BL/6 mice	Improved levels of IDO and IL-10 in serum	[236]
DSS-induced colitis	BM	C57BL/6 mice	Improving IL-10 levels, the inflamed colons	[237]
DSS-induced colitis	BM	BALB/c mice	Potentiating intestinal integrity by up-regulation of E-cadherin expression	[25]
DSS-induced colitis	UCB	C57BL/6 mice	Reducing T cell infiltration into the inflamed colon while promoting Tregs frequency	[114]
DSS-induced colitis	UC	C57BL/6 mice	Attenuation of disease activity index (DAI), histological colitis scores along with promoting body weight	[22]
DSS-induced colitis	BM	C57BL/6 mice	Induction of DCs differentiation into rDCs, leading to ameliorated chronic colitis	[71]
TNBS-induced colitis	BM	Hartley guinea pigs	Diminishment of the immune cell infiltration to damaged colons and also reducing neuronal loss in colon tissue	[238]
TNBS-induced colitis	AT BM	Hartley guinea pigs	Amelioration of enteric neuropathy and plexitis	[239]
DSS-induced colitis	BM	C57BL/6 mice	Improvement of the MSCs therapeutic effects by human cord blood-derived platelet lysate	[126]
DSS-induced colitis	UC	C57BL/6 mice	Amelioration of colon and liver pathology by attenuating the LPS levels and TNF-α, IFN-γ, IL-1β, IL-17A, TLR4, TRAF6, and NF-κB expression in inflamed colon	[240]
TNBS-induced colitis	AT	C57BL/6 mice	Reducing colitis severity and diarrhea and enhancing body weight and survival	[241]
DSS-induced colitis	AM	SD rats	Reducing DAI score, weight loss, colon shortening, and the histological colitis score in association with down-regulation of TNF-α, IL-1β, and MIP	[242]
TNBS-induced colitis	AT	Hartley guinea pigs	Attenuation of weight loss, colonic tissue damage, and immune cell infiltration	[243]
DSS-induced colitis	AT	C57BL/6 mice	Enhancing Tregs by MSCs-secreted PGE2	[79]
TNBS-induced colitis	BM	SD rats	Enhancing MSCs recruitment to the colonic mucosa by combination therapy with G-CSF leads to reduced DAI, MPO activity	[125]
TNBS-induced colitis	UC	BALB/c mice	Improvement of CD5 + B cells and Tregs while decreasing Th1 cells, Th17 cells, and various pro-inflammatory cytokines levels in inflamed colon	[116]
DSS-induced colitis	BM	C57BL/6 mice	Improvement of IL-10 secretion by MSCs upon combination therapy with wogonin	[128]
TNBS-induced colitis	BM	C57BL/6 mice	Exerting gastrointestinal mucosal tissues repair by MSCs-secreted IGFBP7	[244]

MSCs mesenchymal stem/stromal cells, BM bone marrow, UC umbilical cord, UCB umbilical cord blood, AT adipose tissue, TNBS 2,4,6-trinitrobenzene sulfonic acid, DSS dextran sulfate sodium, AOM azoxymethane, Th T helper 1/2/17, FOXP3 Forkhead box P3, IL-1 interleukin-1β, TNF-α Tumor necrosis factor-alpha, NOD2 nucleotide-binding oligomerization domain-containing protein 2, COX-2 cyclooxygenase-2, TGF-β transforming growth factor-beta, PGE2 prostaglandin E2, VEGF vascular endothelial growth factor, Tregs regulatory T cells, TSG-6 TNF-stimulated gene 6, STAT3 signal transducer and activator of transcription 3, IDO indoleamine 2,3-dioxygenase, IFN-γ interferon-gamma, IL interleukin, rDCs regulatory dendritic cells, TLRs toll-like receptors, TRAF6 tumor necrosis factor receptor-associated factor 6, NF-κB nuclear factor kappa B, NLRP3 NLR family pyrin domain containing 3, G-CSF granulocyte colony-stimulating factor, MPO myeloperoxidase, IGFBP7 insulin-like growth factor-binding protein 7, MIF migration inhibitory factor

Back to article page

ISSN: 2047-783X

Contact us

Submission enquiries: jacinth.kennady@springernature.com
General enquiries: info@biomedcentral.com

European Journal of Medical Research

Contact us