Skip to main content

Table 2 Preconditioned MSCs transplantation in IBD animal models

From: Therapeutic potential of mesenchymal stem/stromal cells (MSCs)-based cell therapy for inflammatory bowel diseases (IBD) therapy

Condition

Source

Animal

Results

Refs.

Genetically modified MSCs

 DSS-induced colitis

BM

BALB/c mice

Better homing to the colon and spleen of mice models leads to the reduced Th1 and Th17 cells but improving the Tregs numbers by ICAM-1-overexpressing MSCs

[30]

 TNBS-induced colitis

BM

BALB/c mice

Improved homing to the intestinal mucosa and thus causing a more appreciated curative effect by CXCR‑4-overexpressing MSCs

[161]

 TNBS-induced colitis

BM

BALB/c mice

More powerful migration to the inflamed colons, causing a strong anti-inflammatory effect by CXCR2-overexpressing MSCs

[162]

 DSS-induced colitis

BM

C57BL/6 mice

Down-regulation of miR-141 and miR-139 expression but a promoting ICAM-1 and CXCR4 expression in H19-overexpressing MSCs compared with naïve MSCs

[164]

 DSS-induced colitis

Hair follicle

SD rats

Improving intestinal stem cells proliferation (ISC), attenuating inflammatory factors levels, promoting the anti-inflammatory factors, and also reducing DAI score by Nrf-2-overexpressing MSCs

[166]

 DSS-induced colitis

DP

SD rats

Transdifferentiation of the HGF-overexpressing MSCs into ISC-like cells and suppressing inflammatory responses as well as oxidative stress

[82]

 TNBS-induced colitis

DP

BALB/c mice

Promoting the colon length and supporting intestinal mucosa architecture by enhancing M2 but not M1 macrophage polarization by HIF-1-overexpressing MSCs

[168]

 DSS-induced colitis

BM

C57BL/6 mice

Promoting the Tregs and Th2 cells and improving the IDO expression in colon tissue colon by IFN-γ-overexpressing MSCs

[169]

 DSS-induced colitis

BM

BALB/c mice

Improving the Tregs population in colon tissue by IL-35 overexpressing MSCs

[170]

 DSS-induced colitis

BM

SD rats

Improved homing and robust anti-inflammatory response by CX3CR1/IL-25 dual expressing MSCs

[26]

 DSS-induced colitis

UC

CD11b-DTR mice

Suppression of 15-lox-1 expression in macrophage by miR148b-5p-overexpressing MSCs

[245]

 TNBS-induced colitis

BM

SD rats

Supporting the colonic morphology and amelioration of tissue structure by KGF-overexpressing MSCs

[246]

Pre-treated MSCs

 DSS-induced colitis

UC

C57BL/6 mice

Amelioration of the clinical signs of disease and reducing colon shortening by poly(I: C)-pre-treated MSCs

[143]

 DSS-induced colitis

UC

C57BL/6 mice

Enhancing COX-2, IL-6, and IL-8 expression and targeting macrophage polarization by IL-1β pre-treated MSCs

[145]

 DSS-induced colitis

BM

SD rats

Suppression of the Th17 immune response and promoting T regulatory cell phenotype by IL-25-pre-treated MSCs

[148]

 DSS-induced colitis

Tonsil

C57BL/6J mice

Potentiating the immunomodulatory potential via up-regulation of the COX-2/PGE2 axis in TNF-ɑ pre-treated MSCs

[139]

 TNBS-induced colitis

UC

BALB/c mice

Enhancing the therapeutic competence of MSCs due to the activation of the TLR3–Jagged–1-Notch-1 pathway in poly I: C-pre-treated MSCs

[144]

 DSS-induced colitis

BM

C57BL/6 mice

Attenuation of immune cell infiltration and inflammatory cytokines levels in colon tissue by IFN-γ- and poly I: C-pre-treated MSCs

[152]

 DSS and DNBS-induced colitis

AT

C57BL/6 mice

Secretion of higher levels of TSG-6 and PGE2 by MSCs upon priming with TNF-ɑ leading to the stimulation of phenotypic alterations in macrophages

[19]

  1. MSCs mesenchymal stem/stromal cells, BM bone marrow, UC umbilical cord, AT adipose tissue, DP dental pulp, TNBS 2,4,6-trinitrobenzene sulfonic acid, DSS dextran sulfate sodium, Th T helper 1/2/17, FOXP3 Forkhead box P3, IL-1 interleukin-1β, TNF-α tumor necrosis factor-alpha, PGE2 prostaglandin E2, Tregs regulatory T cells, IDO indoleamine 2,3-dioxygenase, IFN-γ interferon-gamma, IL interleukin, TLRs toll-like receptors, ICAM-1 intercellular adhesion molecule-1, CXCR-4 C-X-C chemokine receptor type 4, TSG6 TNFα-stimulated gene-6, KGF keratinocyte growth factor, CX3CR1 CX3C chemokine receptor 1, MCP-1/CCL2 monocyte chemoattractant protein-1, HGF hepatocyte growth factor, NRF2 nuclear factor erythroid 2-related factor 2, miRNAs microRNAs