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Table 2 Heterogeneity, publication bias, and the overall prevalence of tumors studied in the study based on meta-analysis and random analysis

From: The global prevalence of primary central nervous system tumors: a systematic review and meta-analysis

Tumor type

Number of articles

Sample size

Heterogenicity (I2)

Publication bias (Begg and Mazumdar rank correlation test)

Prevalence (95% CI)

Pituitary adenomas

26

331,575

99.6

0.566

12.2 (95% CI: 9.4–15.7)

Glioma

27

303,967

99.9

0.113

42.8 (95% CI: 29–57.7)

Embryonal tumors

14

207,577

99.3

0.742

3.1 (95% CI: 2.1–4.5)

Ependymal tumors

33

379,800

99.7

0.258

3.2 (95% CI: 2.3–4.4)

Meningioma

42

450,109

99.7

0.438

24.1 (95% CI: 20.5–28.1)

Glial tumor of CNS and pineal gland

17

228,500

99.4

0.692

0.8 (95% CI: 0.4–1.5)

Astrocytic tumors of CNS

33

375,302

99.9

0.744

20.3 (95% CI: 15–26.8)

Oligodendroglial

34

387,350

99.5

0.802

3.9 (95% CI: 3.1–4.9)

Choroid plexus

16

219,897

98.5

0.444

0.4 (95% CI: 0.2–0.7)

Tumors of neuroepithelial tissue

14

162,538

99.8

0.324

34.7 (95% CI: 28.6–41.3)

Glioblastoma

26

616,726

99.9

0.133

17.7 (95% CI: 13.9–22.3)

Germ cell tumors

16

104,207

99.7

0.115

2.6 (95% CI: 0.8–8.2)

Brain tumor

8

314,938

99.2

0.710

70.9 (95% CI: 63.1–77.5)

Spinal tumor

7

108,524

99.9

1.000

12.2 (95% CI: 5–27.1)

Schwannoma

6

65,400

93.3

0.259

6.7 (95% CI: 5.3–8.4)

Medulloblastoma

19

172,593

99.6

0.093

7.7 (95% CI: 4.2–13.6)

Pilocytic astrocytomas

16

427,683

99.7

0.162

3.8 (95% CI: 2.3–6.5)