Table 3 Treatment and follow-up of 14 patients with pSS combined with PN
No. | Gender | Therapeutic regimen | Follow-up time (years) | Clinical symptoms | mRS rating | ||
|---|---|---|---|---|---|---|---|
Pretreatment | End of follow-up | Pretreatment | End of follow-up | ||||
1 | F | MP, CTX, MMF | 3 | Numbness in the nasolabial fold | No remission | 1 | 1 |
2 | F | MP, MMF, HCQ, adenosine cobalamin tablets | 2 | Numbness in the right lower extremity with loss of tendon reflexes in the ankle joint | Recovered tendon reflexes in the right ankle joint, and disappeared numbness | 4 | 1 |
3 | F | MP, HCQ, adenosine cobalamin tablets, carpal tunnel release | 0.5 | Numbness in the right thumb | Partial remission | 2 | 1 |
4 | F | MP, HCQ, MMF | 1 | Numbness on the right side of the face | No remission | 1 | 1 |
5 | F | MP, HCQ, MTX | 2 | Numbness and pins-and-needles sensation on the lateral edge of the right thigh, with numbness and discomfort in the right thumb | Partial remission | 2 | 1 |
6 | F | MP, HCQ, ASA | 1 | Obvious left anterior tibial sensation, and pins-and-needles discomfort in the right upper arm | Partial remission | 2 | 1 |
7 | M | Did not receive treatment | 0 | Numbness on the right side of the face with diminished pain on the lateral edge of the right thigh | – | 2 | – |
8 | F | MP, CTX, IVIg, rituximab | 4 | The numbness and pins-and-needles sensation started from the feet, with gradually going upwards to the part below the chest, with normal urination and defecation, difficulty walking, and muscle atrophy of lower limbs | No remission | 4 | 4 |
9 | F | MP, CTX, MMF, belimumab | 2.5 | Obvious distal numbness in the feet, leading to the middle tibia | No remission | 2 | 2 |
10 | F | MP, CTX | 4 | Obvious numbness in toes, extending to the peri-ankle joints | Complete remission | 2 | 0 |
11 | F | MP, MMF | 3 | Numbness and pins-and-needles sensation in the feet, with gradual involvement of the tibias | Numbness receded to the dorsum of the foot, still leaving numbness and a pins-and-needles sensation in the dorsum of the feet | 3 | 2 |
12 | M | MP, CTX | 0.5 | Numbness and discomfort in the feet | Complete remission | 1 | 0 |
13 | F | MP, MTX, HCQ, CTX | 3 | Obvious cold pain below the knee joints | Partial remission | 2 | 1 |
14 | F | MP, CTX | 2 | Obvious numbness in the hands and feet | Partial remission | 2 | 1 |
15 | M | MP, HCQ, CTX | 1.5 | Burning sensation in the feet | Partial remission | 3 | 1 |