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Table 5 Subgroup analysis of laboratory tests of frail and non-frail patients with diabetes

From: Association of metformin exposure with low risks of frailty and adverse outcomes in patients with diabetes

Variable

Non-frail (n = 340)

Frail (n = 82)

Non-metformin (n = 127)

Metformin (n = 213)

P value

Non-metformin (n = 50)

Metformin (n = 32)

P value

FPG (mmol/L)

6.44 ± 2.02

7.63 ± 2.44

 < 0.001

7.46 ± 3.58

6.69 ± 2.70

0.497

HbA1c (%)

6.97 ± 1.32

7.61 ± 1.58

 < 0.001

6.82 ± 0.96

7.45 ± 1.70

0.244

Triglyceride (mmol/L)

1.52 ± 1.03

1.96 ± 2.11

0.009

1.42 ± 0.63

1.56 ± 0.80

0.509

Total cholesterol (mmol/L)

4.20 ± 1.16

4.28 ± 1.15

0.478

4.05 ± 0.17

4.02 ± 1.31

0.686

HDL (mmol/L)

1.18 ± 0.38

1.09 ± 0.26

0.060

1.05 ± 0.31

1.10 ± 0.27

0.354

LDL (mmol/L)

2.48 ± 0.95

2.48 ± 0.87

0.747

2.39 ± 0.94

2.39 ± 1.11

0.853

Creatinine (umol/L)

78.43 ± 61.16

66.29 ± 19.43

0.084

102.46 ± 74.29

83.06 ± 41.84

0.172

BUN (mmol/L)

6.46 ± 2.70

6.04 ± 1.80

0.120

9.84 ± 5.86

7.49 ± 2.56

0.101

Prealbumin (mg/L)

228.33 ± 49.16

260.22 ± 147.79

 < 0.001

219.1 ± 74.34

227.19 ± 48.47

0.704

Albumin (mg/L)

39.67 ± 4.15

40.41 ± 3.68

0.033

36.94 ± 5.96

37.84 ± 5.28

0.456

Hemoglobin (g/L)

134.06 ± 22.03

137.13 ± 13.90

0.016

123.16 ± 18.36

126.00 ± 26.74

0.287

CRP (mg/L)

2.00 (1.94, 4.00)

2.19 (1.85, 4.00)

0.822

3.47 (2.00, 5.19)

2.00 (1.64, 3.07)

0.017

D-Dimer (ug/mL)

0.33 (0.25, 0.54)

0.26 (0.19, 040)

 < 0.001

0.73 (0.48, 1.53)

0.41 (0.32, 0.70)

0.002

Fibrinogen (g/L)

3.41 ± 0.74

3.36 ± 0.71

0.620

3.71 ± 0.71

3.60 ± 0.84

0.945

NT-proBNP (pg/mL)

128.00 (50.03, 241.50)

57.90 (35.98, 127.25)

 < 0.001

493.50 (221.25, 1367.50)

178.00 (58.60, 394.50)

0.004

Urine mALB/Cre

1.43 (0.35, 8.36)

1.60 (0.30, 7.30)

0.770

3.80 (0.68, 52.80)

17.40 (1.60, 27.10)

0.723

  1. Data for continuous variables are presented as mean ± (standard deviation) or median (interquartile range)
  2. FPG, fasting plasma glucose; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; BUN, blood urea nitrogen; CRP, C-reactive protein; NT-proBNP, N-terminal pro-B-type natriuretic peptide; mALB/Cre, microalbuminuria/creatinine