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Table 1 Classification of clinical characteristics of the COVID-19 cohorts

From: Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome

Characteristics

Mild (References) Cohort

Severe (Cases) Cohort

p-value

N = 123

N = 64

Host factors

 Age (years)—Median (IQR)

62 (21–90)

66.8 (30–95)

 > 0.05

 Gender—(Male/Female)

1.5

2.5

 > 0.05

 ICU admission

0.0

68.0%

 Death

0.0

48.0%

 Smoke

21.0%

14.0%

 > 0.05

 Fever(> 37.3 °C)

24.0%

40.0%

0.03

Comorbilities

 Obesity

13.0%

14.0%

 > 0.05

 Hypertension

51.2%

67.1%

 > 0.05

 Diabetes

16.2%

50.0%

2.4 e-6

 Cardiovascular/Coronary heart disease

38.2%

32.8%

 > 0.05

 Respiratory disease

14.6%

23.4%

 > 0.05

 Cerebrovascular disease

5.6%

7.8%

 > 0.05

 History of cancer

12.1%

3.1%

 > 0.05

 No comorbility

17.8%

6.5%

 > 0.05

Biochemical parameters

 Elevated creatinine (> 1.33 mg/dL)

4.0%

7.0%

 > 0.05

 Reduced albumine (< 4 g/dL)

82.2%

92.3%

 > 0.05

 Elevated AsT (> 40 U/L)

26.6%

53.8%

 > 0.05

 Elevated LDH (> 245 mU/ml)

60.0%

76.9%

 > 0.05

 Elevated C reactive protein (> 8.2 mg/L)

31.0%

61.5%

 > 0.05

 Elevated D-dimer (> 1000 ng/mL)

48.8%

69.2%

 > 0.05

 Elevated white cell count (> 4 × 109/L)

0.0%

0.0%

 > 0.05