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Table 2 Logistic regression analysis by considering the 21 CpGs signature

From: Role of epigenetics in the clinical evolution of COVID-19 disease. Epigenome-wide association study identifies markers of severe outcome

Dataset

Number of samples

Variable

Coef

Std.Err

p-value

OR

(CI)

Sig

This study

 Covid + mild (123) vs Severe (64)

n = 187

PC1

0.94

0.149

3.3E-10

2.55

1.96

3.53

***

 Covid + mild (123) vs Covid- (75)

n = 198

PC1

0.11

0.074

0.11

1.12

0.97

1.30

ns

 Covid + severe (64) vs Covid- (75)

n = 139

PC1

0.83

0.146

1.1E-08

2.3

1.78

3.17

***

GSE167202 (Konigsberg I.R. et al. 2021)

 Covid + Severe (48) vs mild (115)

n = 163

PC1

0.33

0.088

1.16E-04

1.4

1.19

1.68

***

GSE174818 (Balnis J. et al. 2021)

 Covid + Severe (55) vs mild (45)

n = 100

PC1

0.52

0.128

3.75E-05

1.69

1.34

2.23

***

  1. Coef. logistic coefficients, Std.Err. Standard Error, OR Odds Ratio, CI Confidence Interval, Sig. Statistical Significance
  2. ***p <  < 0.01