Fig. 7

Treatment with BIBF1000 reduced allergen-induced expression of α-SMA, PCNA, iNOS, MMP-2, MMP-9, and COX-2 in an experimental model of chronic asthma in mice. A Representative western blots of the expression of α-SMA, PCNA, iNOS, MMP-2, MMP-9, COX-2, and β-actin in each study group. Mean densitometric analysis of immunoblots for B α-SMA, C PCNA, D iNOS, E MMP-2, F MMP-9, and G COX-2 in each study group. All values are expressed as mean ± SEM, n = 5. #p < 0.05 vs. sham control, *p < 0.05 vs. vehicle