Fig. 8

Treatment with BIBF1000 reduced allergen-induced expression of VEGF, FGF-2, PDGF, and TGF inhibited the phosphorylation of AKT and ERK in an experimental model of chronic asthma in mice. A Representative western blots of the expressions of VEGF, FGF-2, PDGF, TGF, p-ERK, ERK, p-AKT, AKT, and β-actin in each study group. Mean densitometric analysis of immunoblots for B VEGF, C FGF-2, D PDGF, and E TGF, F p-ERK/ERK, G p-AKT/AKT ratios in each study group. All values are expressed as mean ± SEM, n = 5, 6. #p < 0.05 vs. sham control, *p < 0.05 vs. vehicle