Fig. 4
B7-H3-CAR-T cells exhibit antitumor activity in a xenograft mouse model of acute myeloid leukaemia (AML). A Schematic diagram of AML transplantation in B-NSG mice. Four female B-NSG mice (6–8 weeks old) in each group (PBS, T cell, and B7-H3-CAR-T cell groups) were injected with 5 × 105 Luciferase-GFP-HEL cells via the tail vein, followed by 1 × 107 effector cells in an equal volume on the day 5. An equal volume of PBS was injected into the mice in the PBS group. B In vivo imaging showing leukaemia progression in mice. C Average weight of the mice. D Mouse survival curve. E Mice survival statistics. **P < 0.01, *P < 0.05, n = 4 mice/group