Table 2 Comparison of renal pathological changes and renal function damage of mice in each group (\(\overline{x}\) ± SD, n = 10)
WT | C3−/− | |||
|---|---|---|---|---|
Sham | AKI-CKD | Sham | AKI-CKD | |
Mesangial hyperplasia score | 0 ± 0 | 1.83 ± 0.45** | 0 ± 0 | 1.15 ± 0.25**# |
Glomerulosclerosis score | 0.11 ± 0.28 | 1.36 ± 0.33** | 0 ± 0 | 0.76 ± 0.08**# |
Tubular interstitial score | 0.33 ± 0.05 | 6.55 ± 0.81** | 0 ± 0 | 3.12 ± 0.46**# |
Glomerular collagen volume fraction (%) | 0 ± 0 | 1.83 ± 0.45** | 0 ± 0 | 1.15 ± 0.25**# |
Renal tubular collagen volume fraction (%) | 0 ± 0 | 0.138 ± 0.021** | 0 ± 0 | 0.016 ± 0.002**# |
BUN(mmol/L) | 11.55 ± 1.17 | 30.20 ± 1.63** | 10.77 ± 1.19 | 19.36 ± 1.98**## |
Scr(umol/L) | 7.12 ± 1.02 | 21.58 ± 2.29** | 6.94 ± 0.82 | 15.78 ± 0.96**## |
UPE (mg/d) | 1.48 ± 0.12 | 10.73 ± 1.08** | 1.52 ± 0.09 | 5.80 ± 1.04**## |