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Table 1 Relationship between risk scores of both diagnostic models and phenotype in the two validation datasets

From: Identification and verification of feature biomarkers associated with immune cells in neonatal sepsis

Validation dataset 1 (DEG model)

Level

High risk

Low risk

P value

 

n = 31

n = 32

 

Group (%)

   

 Control

13 (41.9)

24 (75.0)

0.011

 Infected

18 (58.1)

8 (25.0)

Sex (%)

   

 Female

13 (41.9)

13 (40.6)

1

 Male

18 (58.1)

19 (59.4)

Corrected gestational age (mean (SD))

236.90 (36.03)

262.69 (35.67)

0.006

Birthweight (mean (SD))

1863.29 (1233.33)

2593.25 (1389.79)

0.031

Validation dataset 1 (IRG model)

   

Level

High risk

Low risk

P value

 

n = 31

n = 32

 

Group (%)

   

 Control

9 (29.0)

28 (87.5)

 < 0.001

 Infected

22 (71.0)

4 (12.5)

Sex (%)

   

 Female

14 (45.2)

12 (37.5)

0.613

 Male

17 (54.8)

20 (62.5)

Corrected gestational age (mean (SD))

223.94 (28.09)

275.25 (27.65)

 < 0.001

Birthweight (mean (SD))

1394.23 (929.43)

3047.66 (1204.01)

 < 0.001

Validation dataset 2 (DEG model)

Level

High risk

Low risk

P value

 

n = 10

n = 10

 

Group (%)

   

 Control

1 (10.0)

5 (50.0)

0.141

 Infected

9 (90.0)

5 (50.0)

 Sex (%)

   

Female

2 (20.0)

2 (20.0)

1

 Male

8 (80.0)

8 (80.0)

Corrected gestational age (mean (SD))

242.50 (18.74)

234.40 (25.98)

0.434

Birthweight (mean (SD))

1344.50 (309.98)

1029.50 (385.61)

0.059

Validation dataset 2 (IRG model)

Level

High risk

Low risk

P value

 

n = 10

n = 10

 

Group (%)

   

 Control

0 (0.0)

6 (60.0)

0.011

 Infected

10 (00.0)

4 (40.0)

Sex (%)

   

 Female

4 (40.0)

0 (0.0)

0.087

 Male

6 (60.0)

10 (100.0)

Corrected gestational age (mean (SD))

244.20 (24.56)

232.70 (19.64)

0.263

Birthweight (mean (SD))

1156.00 (348.22)

1218.00 (420.14)

0.724

  1. DEG differentially expressed gene, SD standard deviation, IRG immune-related gene