Table 1 Characteristics of the patients at baseline
Variables | All (N = 1927) | Prior stroke (n = 207) | Non-prior stroke (n = 1720) | ||||
|---|---|---|---|---|---|---|---|
OSA (n = 121) | Non-OSA(n = 86) | P-value | OSA (n = 893) | Non-OSA(n = 827) | P value | ||
Demographics | |||||||
 Age, y | 56.4 ± 10.5 | 62.0 ± 8.9 | 61.6 ± 9.6 | 0.80 | 55.8 ± 10.6 | 55.7 ± 10.3 | 0.78 |
 Male | 1629 (84.5%) | 100 (82.6%) | 65 (75.6%) | 0.21 | 786 (88.0%) | 678 (82.0%) |  < 0.001 |
 BMI, kg/m2 | 27.1 ± 3.6 | 27.9 ± 3.7 | 25.8 ± 3.2 |  < 0.001 | 28.1 ± 3.5 | 26.0 ± 3.4 |  < 0.001 |
 Neck, circumference, cm | 41 (38–43) | 41 (39 to 44) | 39 (37 to 41) |  < 0.001 | 41.5 (39 to 44) | 40 (38 to 42) |  < 0.001 |
 Waist, circumference, cm | 99 (93 to 105) | 101 (97 to 109) | 96 (90 to 100.3) |  < 0.001 | 101 (95 to 108) | 97 (91 to 102) |  < 0.001 |
 Systolic BP, mm Hg | 126 (117–138) | 127 (118 to 145) | 130 (120 to 142) | 0.47 | 126 (117 to 138) | 126 (116 to 137) | 0.26 |
 Diastolic BP, mm Hg | 76 (70–84) | 76 (70 to 83.5) | 75 (68.8 to 81.0) | 0.64 | 78 (70 to 86) | 75 (69 to 83) |  < 0.001 |
Medical history | |||||||
 Diabetes mellitus | 609 (31.6%) | 50 (58.1%) | 36 (41.9%) | 0.46 | 262 (29.3%) | 254 (30.7%) | 0.53 |
 Hypertension | 1247 (64.7) | 103 (85.1%) | 68 (79.1%) | 0.26 | 588 (65.8%) | 488 (59.0%) | 0.003 |
 Hyperlipidemia | 637 (33.1) | 52 (43.0%) | 31 (36.0%) | 0.32 | 291 (32.6%) | 263 (31.8%) | 0.73 |
 Prior MI | 316 (16.4) | 23 (19.0%) | 14 (16.3%) | 0.61 | 154 (17.2%) | 125 (15.1%) | 0.23 |
 Previous PCI | 399 (20.7) | 33 (27.3%) | 16 (18.6%) | 0.15 | 201 (22.5%) | 149 (18.0%) | 0.021 |
 Previous CABG | 29 (1.5) | 1 (0.8%) | 1 (1.2%) | 0.81 | 17 (1.9%) | 10 (1.2%) | 0.25 |
 Smoking |  |  |  | 0.73 |  |  | 0.08 |
  No | 953 (49.5%) | 76 (62.8%) | 52 (60.5%) |  | 442 (49.5%) | 383 (46.3%) |  |
  Yes | 974 (50.5%) | 45 (37.2%) | 34 (39.5%) |  | 451 (50.5%) | 444 (53.7%) |  |
Baseline tests | |||||||
 Glucose, mmol/L | 5.98 (5.32 to 7.51) | 6.10 (5.47 to 8.24) | 6.10 (5.28 to 7.44) | 0.24 | 6.04 (5.33 to 7.61) | 5.90 (5.29 to 7.29) | 0.17 |
 Hemoglobin A1C, % | 6.10 (5.60 to 7.00) | 6.30 (5.60 to 7.38) | 6.10 (5.70 to 7.00) | 0.35 | 6.10 (5.70 to 7.00) | 6.00 (5.60 to 6.90) | 0.028 |
 Triglyceride, mmol/L | 1.51 (1.10 to 2.20) | 1.44 (1.07 to 1.90) | 1.38 (1.11 to 1.89) | 0.53 | 1.59 (1.13 to 2.31) | 1.47 (1.05 to 2.18) | 0.16 |
 Total Cholesterol, mmol/L | 4.12 (3.47 to 4.91) | 3.93 (3.40 to 4.50) | 3.92 (3.46 to 4.80) | 0.47 | 4.18 (3.52 to 4.94) | 4.09 (3.41 to 4.96) | 0.35 |
 HDL-C, mmol/L | 1.00 (0.86 to 1.16) | 0.98 (0.87 to 1.14) | 1.01 (0.84 to 1.17) | 0.80 | 0.98 (0.85 to 1.13) | 1.02 (0.87 to 1.18) | 0.003 |
 LDL-C, mmol/L | 2.43 (1.90 to 3.09) | 2.34 (1.92 to 2.88) | 2.31 (1.90 to 3.00) | 0.72 | 2.46 (1.95 to 3.11) | 2.42 (1.83 to 3.11) | 0.17 |
 Hs-CRP, mmol/L | 2.06 (0.82 to 6.13) | 2.35 (0.86 to 9.25) | 1.50 (0.65 to 3.98) | 0.24 | 2.53 (1.05 to 7.24) | 1.44 (0.61 to 4.69) |  < 0.001 |
 LVEF, % | 61.0 (56.0 to 65.0) | 62.0 (55.5 to 65.5) | 58.0 (66.0 to 66.0) | 0.86 | 60.0 (55.0 to 65.0) | 62.0 (57.0 to 66.0) | 0.010 |
Diagnosis | Â | Â | Â | 0.96 | Â | Â | 0.013 |
 Unstable angina | 1132 (58.7%) | 74 (61.2%) | 54 (62.8%) |  | 498 (55.8%) | 506 (61.2%) |  |
 NSTEMI | 365 (18.9%) | 23 (19.0%) | 15 (17.4%) |  | 168 (18.8%) | 159 (19.2%) |  |
 STEMI | 430 (22.3%) | 24 (19.8%) | 17 (19.8%) |  | 227 (25.4%) | 162 (19.6%) |  |
Procedures | |||||||
 Vessels |  |  |  | 0.64 |  |  | 0.19 |
 0 | 170 (8.8%) | 9 (7.4%) | 7 (7.8%) |  | 69 (7.7%) | 85 (10.3%) |  |
 1 | 512 (26.6%) | 21 (17.4%) | 19 (22.1%) |  | 240 (26.9%) | 232 (28.1%) |  |
  ≥ 2 | 1245 (64.6%) | 91 (75.2%) | 60 (69.8%) |  | 584 (65.4%) | 510 (61.7%) |  |
 PCI | 1209 (62.7%) | 72 (59.5%) | 52 (60.5%) | 0.89 | 595 (66.6%) | 490 (59.3%) | 0.002 |
 CABG | 130 (6.7%) | 14 (11.6%) | 10 (11.6%) | 0.99 | 45 (5.0%) | 61 (7.4%) | 0.044 |
Medications on discharge | |||||||
 Aspirin | 1877 (97.4%) | 114 (94.2%) | 81 (94.2%) | 0.99 | 873 (97.8%) | 809 (97.8%) | 0.93 |
 P2Y12 inhibitors | 1768 (91.7%) | 110 (90.9%) | 80 (93.0%) | 0.59 | 828 (92.7%) | 750 (90.7%) | 0.13 |
 β-blockers | 1488 (77.2%) | 92 (76.0%) | 52 (60.5%) | 0.016 | 707 (79.2%) | 637 (77.0%) | 0.28 |
 ACEIs/ARBs | 1195 (62.0%) | 82 (67.8%) | 55 (64.0%) | 0.57 | 583 (65.3%) | 475 (57.4%) | 0.001 |
 Statins | 1897 (98.4%) | 119 (98.3%) | 83 (96.5%) | 0.40 | 878 (98.3%) | 817 (98.8%) | 0.42 |