Clinical significance of obstructive sleep apnea in patients with acute coronary syndrome with or without prior stroke: a prospective cohort study

Table 3 Cox regression analyses evaluating the association between OSA and risk of cardiovascular events by a history of stroke

Variables	Prior stroke (n = 207)				Non-prior stroke (n = 1720)
Variables	Unadjusted HR (95% CI)	P-value	Adjusted HR^a (95% CI)	P-value	Unadjusted HR (95% CI)	P value	Adjusted HR^a (95% CI)	P value
MACCE	1.93 (1.10 to 3.36)	0.021	2.04 (1.13 to 3.69)	0.018	1.26 (1.01 to 1.56)	0.040	1.21 (0.96 to 1.52)	0.10
Cardiovascular death	1.15 (0.32 to 4.06)	0.83	1.09 (0.28 to 4.23)	0.90	1.23 (0.54 to 2.80)	0.63	1.05 (0.44 to 2.49)	0.91
Myocardial infarction	4.15 (0.48 to 35.6)	0.19	6.61 (0.61 to 71.56)	0.12	1.55 (0.85 to 2.84)	0.15	1.44 (0.76 to 2.74)	0.27
Stroke	3.22 (0.91 to 11.4)	0.07	3.03 (0.82 to 11.25)	0.10	0.83 (0.40 to 1.75)	0.62	0.84 (0.39 to 1.83)	0.67
Ischemia-driven revascularization	1.57 (0.63 to 3.89)	0.33	1.62 (0.62 to 4.23)	0.33	1.32 (0.94 to 1.85)	0.11	1.27 (0.89 to 1.82)	0.19
Hospitalization for unstable angina	1.37 (0.65 to 2.87)	0.41	1.42 (0.65 to 3.11)	0.38	1.25 (0.97 to 1.61)	0.09	1.21 (0.92 to 1.58)	0.17
Hospitalization for heart failure	1.16 (0.19 to 6.98)	0.87	0.96 (0.14 to 6.80)	0.97	0.95 (0.36 to 2.53)	0.92	0.81 (0.29 to 2.26)	0.69
Composite of major cardiovascular events^b	2.73 (1.17 to 6.38)	0.020	2.84 (1.17 to 6.93)	0.022	1.29 (0.86 to 1.95)	0.23	1.19 (0.77 to 1.84)	0.44
All-cause death	0.67 (0.22 to 1.99)	0.47	0.67 (0.21 to 2.17)	0.50	1.01 (0.51 to 1.99)	0.99	0.86 (0.42 to 1.75)	0.68
All repeat revascularization	1.65 (0.74 to 3.65)	0.22	1.87 (0.81 to 4.34)	0.14	1.18 (0.89 to 1.55)	0.26	1.11 (0.83 to 1.49)	0.49

MACCE, major adverse cardiovascular and cerebrovascular event including cardiovascular death, MI, stroke, ischemia-driven revascularization, or hospitalization for unstable angina or heart failure. OSA obstructive sleep apnea
^aModel adjusted for age, sex, BMI, smoker, hypertension, diabetes mellitus and dyslipidemia
^bComposite end point of major cardiovascular events included cardiovascular death, myocardial infarction, and stroke

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