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Table 2 Assessment of tumor microenvironment of breast cancer bone metastasis

From: Metastasis of breast cancer to bones alters the tumor immune microenvironment

Variable

Median

IQR

Stroma (%)

70

40–80

Stromal TILs (%)

5

5–10

Stromal CD4 + TILs (/mm2)

12.5

1–27.5

Stromal CD8 + TILs (/mm2)

5

1–35

CD4/CD8 ratio

1

0.53–5.18

Stromal HLA-DR + macrophages (/mm2)

85

60–120

Stromal CD68 + macrophages (/mm2)

37.5

12.5–57.5

HLA-DR/CD68 ratio

2.27

1.44–5

PD-1 expression

43/63

68.25 (%)

PD-L1 expression

5/63

7.94 (%)

Osteoclasts (/mm2)

0.33

0–3