The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity

Table 4 Clinical parameters in COPD patients

	n = 98	95% CI
	n = 98	lower CI	upper CI
AECOPD/previous year, med (IQR)	2 (2)	2.0	3.0
COPD duration in years, med (IQR)	7 (6)	6.0	8.0
CAT score, med (IQR)	18.5 (14.2)	16.0	20.0
mMRC score, med (IQR)	2.0 (2.0)	2.0	3.0
CRP, med (IQR)	3.4 (6.2)	2.4	4.6
WBC (10 ^ 9/l), mean ± SD	8.4 ± 2.6	7.9	8.9
Serum neutrophils (10 ^ 9/l), mean ± SD	5.4 ± 2.3	5.0	5.9
Serum eosinophils (10 ^ 9/l), mean ± SD	0.2 ± 0.2	0.2	0.2
Serum eosinophils, (%)	2.3 ± 1.7	2.0	2.7
Serum lymphocytes (10 ^ 9/l), mean ± SD	2.1 ± 0.8	1.9	2.3
FEV_1/FVC, mean ± SD	43.7 ± 12.6	41.2	46.3
Post-BD FVC% predicted, mean ± SD	85.6 ± 19.4	81.7	89.5
Post-BD FEV₁% predicted, mean ± SD	47 ± 18.6	43.3	50.8
DLCO% predicted, mean ± SD	50.1 ± 21.8	45.8	54.5
KCO% predicted, mean ± SD	60.8 ± 24.1	55.8	65.7
TLC% predicted, mean ± SD	125.5 ± 23.5	120.7	130.3
RV% predicted, mean ± SD	194.6 ± 63.4	181.7	207.6
VC% predicted, mean ± SD	91.3 ± 19.5	87.3	95.3
RV% TLC predicted, mean ± SD	146.4 ± 28.1	140.7	152.1
R tot, mean ± SD	0.6 ± 0.3	0.5	0.6
IC% predicted, mean ± SD	85.1 ± 30	79.0	91.3
ERV% predicted, mean ± SD	112.0 (66.0)	97.9	121.4

Data are expressed as the mean ± SD, n (%) or med (95% CI)
BD bronchodilator, AECOPD acute exacerbation of chronic obstructive disease, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, DLCO diffusion capacity for carbon monoxide (CO), KCO carbon monoxide transfer coefficient, TLC total lung capacity, RV residual volume, VC vital capacity, IC inspiratory capacity, ERV expiratory reserve volume, R tot total resistance, WBC count white blood cell count, CRP C-reactive protein, CAT COPD Assessment Test, MMP-9 matrix metalloproteinase 9, TIMP-1 tissue inhibitor of metalloproteinase 1

ISSN: 2047-783X