European Journal of Medical Research

Table 5 Correlation of MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio with lung function, clinical and CBC parameters

From: The usefulness of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio for diagnosis and assessment of COPD severity

	MMP-9		TIMP-1		MMP-9/TIMP-1
	r	p	r	p	r	p
FEV₁/FVC	− 0.308	0.005	− 0.085	0.456	− 0.330	0.003
FVC (%) pred	− 0.294	0.008	− 0.043	0.704	− 0.282	0.011
FEV₁ (%) pred	− 0.367	p ≤ 0.001	− 0.054	0.636	− 0.392	p ≤ 0.001
DLCO (%) pred	− 0.154	0.172	− 0.117	0.302	− 0.153	0.175
TLC (%) pred	0.012	0.918	− 0.119	0.293	0.105	0.355
RV (%) pred	0.220	0.050	− 0.031	0.786	0.277	0.013
VC (%) pred	− 0.323	0.003	− 0.152	0.178	− 0.263	0.018
RV% TLC pred	0.308	0.005	0.015	0.895	0.335	0.002
IC (%) pred	− 0.359	p ≤ 0.001	− 0.148	0.189	− 0.291	0.009
BMI (kg/m²)	0.157	0.164	0.289	0.009	0.043	0.703
CRP (mg/l)	0.301	0.007	0.370	0.001	0.164	0.148
WBC (10 ^ 9/l)	0.462	p ≤ 0.001	0.293	0.009	0.339	0.002
Ne (10 ^ 9/l)	0.478	p ≤ 0.001	0.346	0.002	0.322	0.004
Ne (%)	0.315	0.005	0.225	0.046	0.194	0.086
Eo (10 ^ 9/l)	0.016	0.890	0.007	0.949	0.045	0.698
Eo (%)	− 0.140	0.222	− 0.175	0.125	−0.038	0.743
Hgb (g/l)	0.352	0.002	0.263	0.020	0.243	0.032
CAT	0.273	0.014	0.053	0.641	0.312	0.005
mMRC	0.288	0.010	0.103	0.365	0.281	0.011

FEV₁ forced expiratory volume in 1 s, FVC forced vital capacity, DLCO diffusion capacity for carbon monoxide (CO), KCO carbon monoxide transfer coefficient, TLC total lung capacity, RV residual volume, VC vital capacity, IC inspiratory capacity, ERV expiratory reserve volume, R tot total resistance, WBC count white blood cell count, CRP C- reactive protein, Ne absolute neutrophil count, Hgb hemoglobin, CAT COPD Assessment Test, mMRC modified Medical Research Council, MMP-9 matrix metalloproteinase 9, TIMP-1 tissue inhibitor of metalloproteinase 1

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ISSN: 2047-783X

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