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Table 1 Clinical characteristics of the patients with PLA2R-associated MN

From: The characters of antibodies against PLA2R in healthy individuals and in the patient with PLA2R associated membranous nephropathy

Characters

Anti-PLA2R positive (n = 18)

Anti-PLA2R negative (n = 12)

P

Age (years)

53.6 ± 14.5

47.6 ± 14.8

0.282

Gender (male/female)

11/7

9/3

0.694

Clinical features

 Urinary protein (g/24 h)

4.5 (2.7, 8.9)

2.3 (1.5, 3.9)

0.025

 Serum albumin (g/l)

27.5 ± 7.5

31.9 ± 7.5

0.122

 Nephrotic syndrome (n, %)

12 (66.7%)

2 (16.7%)

0.011

 eGFR (ml/min/1.73m2)

83.9 ± 28.9

93.1 ± 15.3

0.269

 Anti-PLA2R antibody level (RU/ml)

84.0 (41.8, 221.5)

2.8 (1.0, 6.6)

 < 0.001

Histological features

n = 15

n = 12

 

 Stages of membranous injury, I/II/III + IV

7/7/1/0

7/5/0/0

0.500

 Intensity of glomerular IgG deposit

3.4 ± 0.4

3.0 ± 0.7

0.150

 Glomerular IgG1/IgG2/IgG3/IgG4 deposit, n

15/7/6/15

12/5/3/12

 

 C3 deposit, n (%)

13 (86.7)

9 (75)

0.628

 Intensity of PLA2R staining

2.7 ± 0.7

2.5 ± 0.6

0.426

  1. eGFR calculated by CKD-EPI Statistically
  2. significant P values are shown in bold