Table 2 Renal pathological parameters of patients with IgAN in the Mfn2-negative group and Mfn2-positive group
From: Mitofusin2 expression is associated with podocyte injury in IgA nephropathy
Mfn2 ( +) (n = 86) | Mfn2(−) (n = 28) | P | |
|---|---|---|---|
M [n (%)] | M0 0 (0%) M1 86 (100%) | M0 1 (3.57) M1 26(96.43%) | 0.25 |
E[n (%)] | E0 45 (52.32%) E1 41 (47.67%) | E0 15 (53.57%) E1 13 (46.43%) | 0.58 |
S [n (%)] | S0 25 (29.07) S1 61 (70.93%) | S0 2 (7.14%) S1 26 (92.86%) | 0.04 |
T [n (%)] | T0 73 (84.88%) T1 13 (15.12%) T2 0 (0%) | T0 14 (50%) T1 12 (42.85%) T2 2 (7.14%) | 0.01 |
C [n (%)] | C0 38 (44.19%) C1 47 (54.65%) C2 1 (1.16%) | C0 10 (35.71%) C1 18 (64.29%) C2 0 (0%) | 0.58 |
Intensity of IgA deposition | 2.98 ± 0.32 | 2.89 ± 0.42 | 0.21 |
Intensity of IgG deposition | 0.72 ± 0.65 | 0.71 ± 0.62 | 0.96 |
Intensity of IgM deposition | 1.14 ± 0.33 | 1.37 ± 0.63 | 0.07 |
Intensity of C3 deposition | 2.24 ± 0.59 | 2.21 ± 0.73 | 0.88 |
C4 deposition [n (%)] | 6 (7.1%) | 3 (10.7%) | 0.68 |
C1q deposition [n (%)] | 22 (25.6%) | 13 (46.4%) | 0.05 |
M/A | 0.112 ± 0.483 | 0.156 ± 0.67 | 0.001 |
Length to width ratio | 2.03 ± 0.93 | 1.23 ± 0.24 | 0.0001 |
Degree of podocyte fusion | 2.10 ± 0.81 | 2.78 ± 1.24 | 0.02 |