Variable | Univariate Analysis | Multivariate Analysis | ||
---|---|---|---|---|
OR (95% CI) | P-value | OR (95% CI) | P-value | |
Age (per increase of 1-year) | 1.04 (1.02–1.06) | 0.000 | 1.03 (1.00–1.06) | 0.021 |
Sex (female vs male) | 0.53 (0.34–0.83) | 0.005 | 0.89 (0.52–1.53) | 0.676 |
Body mass index (per increase of 1 point) | 0.91 (0.87–0.95) | 0.000 | 0.94 (0.89–0.99) | 0.019 |
Smoking index (pack-year) | 1.00 (0.99–1.01) | 0.202 |  |  |
FEV1 (% predicted) | 0.97 (0.96–0.98) | 0.000 | 0.98 (0.97–1.00) | 0.080 |
FVC (% predicted) | 0.98 (0.97–0.99) | 0.000 | 0.99 (0.98–1.01) | 0.647 |
VA (% predicted) | 0.97 (0.96–0.98) | 0.000 | 1.01 (0.99–1.02) | 0.528 |
DLCO (% predicted) (≥ 80 vs < 80%) | 3.14 (2.13–4.63) | 0.000 | 1.03 (0.59–1.80) | 0.911 |
FVC/DLCO (≥ 0.44 vs < 0.44 l/mmol/min/kPa) | 2.56 (1.18–3.62) | 0.000 | 2.11 (1.30–3.45) | 0.003 |
Hypertension (yes vs no) | 1.10 (0.77–1.57) | 0.610 |  |  |
Diabetes (yes vs no) | 1.23 (0.66–2.28) | 0.515 |  |  |
Coronary heart disease (yes vs no) | 3.11 (2.18–4.12) | 0.000 | 3.23 (2.15–4.84) | 0.000 |
SABD (yes vs no) | 1.18 (0.43–3.23) | 0.745 |  |  |
ICS/LABA (yes vs no) | 0.83 (0.57–1.19) | 0.306 |  |  |
ICS/LABA + LAMA (yes vs no) | 0.92 (0.64–1.33) | 0.669 |  |  |
LAMA (yes vs no) | 1.37 (0.95–1.98) | 0.093 |  |  |
pH (≥ 7.4 vs < 7.4) | 0.54 (0.37–0.78) | 0.001 | 0.91 (0.57–1.45) | 0.701 |
PaO2 (≥ 60 vs < 60 mmHg) | 3.47 (2.36–5.10) | 0.000 | 1.76 (1.10–2.82) | 0.019 |
PaCO2 (≥ 50 vs < 50 mmHg) | 4.50 (2.70–7.50) | 0.000 | 3.13 (1.57–6.23) | 0.001 |
Neutrophil count (per increase of 1 × 109/L) | 1.11 (1.04–1.18) | 0.002 | 1.07 (0.99–1.15) | 0.063 |
Albumin (per increase of 1 standard deviation g/L) | 0.94 (0.91–0.98) | 0.005 | 1.01 (0.96–1.06) | 0.726 |
Creatinine (per increase of 1 standard deviation μmol/L) | 1.01 (1.00–1.02) | 0.052 |  |  |
BUN (per increase of 1 standard deviation mmol/L) | 1.15 (1.06–1.26) | 0.001 | 1.04 (0.94–1.15) | 0.480 |
Cystatin C (per increase of 1standard deviation mg/L) | 3.03 (1.64–5.61) | 0.000 | 1.97 (0.94–4.13) | 0.073 |