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  1. Content type: Research

    We conducted a single-centre, randomised, double-blinded, placebo-controlled phase II clinical study to test safety and efficacy of a 12-week therapy with low-dose (700 mg/daily) or high-dose (2800 mg/daily) o...

    Authors: N Dauletbaev, P Fischer, B Aulbach, J Gross, W Kusche, U Thyroff-Friesinger, TOF Wagner and J Bargon

    Citation: European Journal of Medical Research 2009 14:352

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  2. Content type: Research

    Only 50% of gallbladder cancers (GBC) are recognized before operation and the remaining tumors are diagnosed during surgery or afterwards by the pathologist. These situations may demand substantial modificatio...

    Authors: F Löhe, G Meimarakis, C Schauer, M Angele, KW Jauch and RJ Schauer

    Citation: European Journal of Medical Research 2009 14:345

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  3. Content type: Research

    In this paper, we describe the main objectives, the study design and the onset of the patient cohort of the German Competence Network for HIV/AIDS (KompNet). Furthermore, we depict sociodemographic and clinica...

    Authors: K Jansen, C Michalik, M Hahn, S Dupke, S Esser, H Jaeger, S Köppe, A Moll, A Plettenberg, RE Schmidt, A Skaletz-Rorowski and NH Brockmeyer

    Citation: European Journal of Medical Research 2009 14:323

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  4. Content type: Case report

    Rectal polypectomy causes thinning (or even perforation) of the rectal wall in addition to thermic injury at the polypectomy site.

    Authors: WY Khoder, AJ Becker, B Schlenker, S Tritschler, PJ Bastian and CG Stief

    Citation: European Journal of Medical Research 2009 14:320

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  5. Content type: Research

    Macrolide antibiotics are reported to modulate the production of cytokines in various type of cells. We examined the effect of macrolide antibiotics on inflammatory cytokines (IL-6 and IL-8) and chemical media...

    Authors: A Kamemoto, T Ara, T Hattori, Y Fujinami, Y Imamura and P-L Wang

    Citation: European Journal of Medical Research 2009 14:309

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  6. Content type: Research

    High blood pressure is one of the most important risk factors, directly responsible for increasing the cardiovascular morbidity and mortality. The primary objective was to evaluate the efficacy of metoprolol X...

    Authors: A Pareek, SD Zawar, SB Salagre, NB Chandurkar and ND Karnik

    Citation: European Journal of Medical Research 2009 14:297

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  7. Content type: Research

    Blood loss during radical prostatectomy has been a long term issue. The aim of this study was to investigate the influence of the training level of the first assistant regarding blood loss in open retropubic r...

    Authors: A Karl, A Buchner, H Beckerv, M Staehler, M Seitz and C Stief

    Citation: European Journal of Medical Research 2009 14:292

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  8. Content type: Research

    Multiple severe trauma frequently leads to massive dysbalances of the human immune system. This phenomenon is known as "Systemic Inflammatory Response Syndrome (SIRS)". SIRS is connected to multiple organ failure...

    Authors: V Bogner, L Keil, K-G Kanz, C Kirchhoff, BA Leidel, W Mutschler and P Biberthaler

    Citation: European Journal of Medical Research 2009 14:284

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  9. Content type: Case report

    Dysplasia epiphysealis hemimelica (DEH) or Trevor's Disease is a very rare disease with an estimated incidence of one in 1.000.000. The majority of cases reported affect the lower limb and only 25 case reports...

    Authors: T Vogel, T Skuban, C Kirchhoff, A Baur-Melnyk, S Siegert and B Heimkes

    Citation: European Journal of Medical Research 2009 14:272

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  10. Content type: Research

    Currently, total hip replacement (THR) is most commonly performed via a posterior or a direct lateral approach, but the impact of the latter on the invention's outcome has yet not been quantified.

    Authors: W-C Witzleb, L Stephan, F Krummenauer, A Neuke and K-P Günther

    Citation: European Journal of Medical Research 2009 14:256

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  11. Content type: Research

    The search for influencing factors and new pathways in aseptic loosening of arthroplasties is a major focus of recent studies. Analyses of polymorphisms of genes revealed a correlation between a specific allel...

    Authors: C Wedemeyer, MD Kauther, S Hanenkamp, H Nückel, M Bau, W Siffert and HS Bachmann

    Citation: European Journal of Medical Research 2009 14:250

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  12. Content type: Research

    There is only little data on immune reconstitution in antiretroviral naïve AIDS-patients with toxoplasmosis. The observation of several cases with reduced increase of CD4-cells upon start of antiretroviral tre...

    Authors: U Kastenbauer, E Wolf, C Kollan, O Hamouda and JR Bogner

    Citation: European Journal of Medical Research 2009 14:244

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  13. Content type: Review

    Desmoid tumors are fibroblastic/myofibroblastic neoplasms, which originate from musculo-aponeurotic structures and are classified as deep fibromatoses. Despite their benign histologic appearance and lack of me...

    Authors: E Bölke, H Krasniqi, G Lammering, R Engers, C Matuschek, S Gripp, PA Gerber, G Fischer, M Peiper, S Shaikh, W Budach and K Orth

    Citation: European Journal of Medical Research 2009 14:240

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  14. Content type: Research

    Pneumatosis intestinalis has been increasingly detected in recent years with the more frequent use of computed tomography for abdominal imaging of the intestine. The underlying causes of the gas found during r...

    Authors: PN Khalil, S Huber-Wagner, R Ladurner, A Kleespies, M Siebeck, W Mutschler, K Hallfeldt and K-G Kanz

    Citation: European Journal of Medical Research 2009 14:231

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  15. Content type: Research

    Poor adherence to complex multimodal therapies is a widely recognized problem in the daily care of dialysis patients, contributing to excess morbidity and mortality of this population. While a few studies have...

    Authors: H Schmid, B Hartmann and H Schiffl

    Citation: European Journal of Medical Research 2009 14:185

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  16. Content type: Case report

    Lipodystrophies represent a heterogeneous group of diseases characterized by altered body fat repartition and often metabolic alterations. Here we illustrate a 20 year old male with myositis in association wit...

    Authors: H-J Gdynia, P Weydt, A Ernst, S Klein, A-D Sperfeld and A Riecker

    Citation: European Journal of Medical Research 2009 14:228

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  17. Content type: Research

    Several epidemiological studies address psychosomatic 'self regulation' as a measure of quality of life aspects. However, although widely used in studies with a focus on complementary cancer treatment, and rec...

    Authors: A Büssing, M Girke, C Heckmann, F Schad, T Ostermann and M Kröz

    Citation: European Journal of Medical Research 2009 14:223

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  18. Content type: Research

    Maternal body mass index has an impact on maternal and fetal pregnancy outcome. An increased maternal BMI is known to be associated with admission of the newborn to a neonatal care unit. The reasons and impact...

    Authors: P Kalk, F Guthmann, K Krause, K Relle, M Godes, G Gossing, H Halle, R Wauer and B Hocher

    Citation: European Journal of Medical Research 2009 14:216

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  19. Content type: Research

    Chronic kidney disease is frequent in patients after orthotopic liver transplantation (OLT) and has impact on survival. Patients receiving calcineurin inhibitors (CNI) are at increased risk to develop impaired...

    Authors: T Gerhardt, B Terjung, P Knipper, H Palmedo, RP Woitas, J Kalff, T Sauerbruch and U Spengler

    Citation: European Journal of Medical Research 2009 14:210

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  20. Content type: Research

    A cyclosporine (CsA)-based immunosuppression is associated with an increased incidence of cholelithiasis after heart transplantation. It is not known if tacrolimus (Tac) has comparable biliary side effects in ...

    Authors: J Stief, HU Stempfle, M Götzberger, P Überfuhr, M Köpple, P Lehnert, C Kaiser and U Schiemann

    Citation: European Journal of Medical Research 2009 14:206

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  21. Content type: Research

    To assess the efficacy and safety of a treatment switch from a twice-daily (BID) regimen containing zidovudine (ZDV) and lamivudine (3TC) plus a third agent to a once daily (QD) regimen containing the fixed-do...

    Authors: K Arasteh, L Weitner, S Fenske, B Kuhlmann, M Freiwald, R Ebrahimi, L Gallo, B Ranneberg and T Mertenskoetter

    Citation: European Journal of Medical Research 2009 14:195

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  22. Content type: Research

    In HIV-infected patients, manifestations of the disease are common in the gastrointestinal tract. The objective of our study was to evaluate the diagnostic yield of the Given® Video Capsule System (Given Imaging,...

    Authors: M Oette, A Stelzer, K Göbels, M Wettstein, A Sagir, T Feldt and D Häussinger

    Citation: European Journal of Medical Research 2009 14:191

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  23. Content type: Review

    Here we report a 33-years-old woman with hereditary spherocytosis and hemochromatosis due to homozygosity for the C282Y mutation of the HFE gene. The coinheritance of both conditions led to severe iron overload a...

    Authors: A Höblinger, C Erdmann, CP Strassburg, T Sauerbruch and F Lammert

    Citation: European Journal of Medical Research 2009 14:182

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  24. Content type: Research

    Superstition is common and causes discomfiture or fear, especially in patients who have to undergo surgery for cancer. One superstition is, that moon phases influence surgical outcome. This study was performed...

    Authors: A Kuehnl, M Herzog, M Schmidt, H-M Hornung, K-W Jauch, RA Hatz and C Graeb

    Citation: European Journal of Medical Research 2009 14:178

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  25. Content type: Research

    Infection of the spleen with echinococcus is a rare clinical entity. Because the diagnosis of a splenic infestation with echinococcus is sometimes delayed, large hydatid cysts or pseudotumors may develop, dema...

    Authors: G Meimarakis, G Grigolia, F Loehe, KW Jauch and RJ Schauer

    Citation: European Journal of Medical Research 2009 14:165

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  26. Content type: Research

    Evaluation of gait performance and muscle activity patterns as well as clinical efficacy and safety after single intraarticular injection with hyaluronan compared with triamcinolone in patients with knee osteo...

    Authors: A Skwara, R Ponelis, CO Tibesku, D Rosenbaum and S Fuchs-Winkelmann

    Citation: European Journal of Medical Research 2009 14:157

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  27. Content type: Research

    LIGHT (TNFSF 14) belongs to the tumor necrosis factor superfamily and is expressed by activated T cells as well as various types of antigen presenting cells. LIGHT binds to its cellular receptors TR2 and LTßR ...

    Authors: S Celik, V Shankar, A Richter, H-J Hippe, M Akhavanpoor, F Bea, C Erbel, S Urban, N Blank, N Wambsganss, HA Katus and TJ Dengler

    Citation: European Journal of Medical Research 2009 14:147

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  28. Content type: Research

    Among people with HIV, we examined symptom attribution to HIV or HIV-therapy, awareness of potential side effects and discontinuation of treatment, as well as sex/gender differences.

    Authors: H Kremer, U Sonnenberg-Schwan, G Arendt, NH Brockmeyer, A Potthoff, A Ulmer, K Graefe, T Lorenzen, W Starke and UA Walker

    Citation: European Journal of Medical Research 2009 14:139

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  29. Content type: Case report

    Multiclass-drug resistance, often caused by poor treatment compliance, is a challenging problem in all categories of HIV-infected patients. Selective pressure is higher in youth for both biological and behavio...

    Authors: R Rosso, C Bernardini, B Bruzzone, G Secondo, G Icardi, C Viscoli and A Di Biagio

    Citation: European Journal of Medical Research 2009 14:136

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  30. Content type: Research

    The Complex Regional Pain Syndrome I (CRPS I) is a disease that might affect an extremity after trauma or operation. The pathogenesis remains yet unclear. It has clinical signs of severe local inflammation as ...

    Authors: Ch Schinkel, A Scherens, M Köller, G Roellecke, G Muhr and C Maier

    Citation: European Journal of Medical Research 2009 14:130

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  31. Content type: Research

    Tissue hypoxia after blood loss, replantation and flap reperfusion remains a challenging task in surgery. Normovolemic hemodilution improves hemorheologic properties without increasing oxygen carrying capacity...

    Authors: O Goertz, MH Kirschner, H Lilienfein, P Babilas, HU Steinau, C Andree, A Daigeler, A Stachon, H Homann and S Langer

    Citation: European Journal of Medical Research 2009 14:123

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  32. Content type: Research

    Recently it has been shown that there is not only endocrine insufficiency in diabetic patients, but a frequent co-morbidity of both, the endocrine and exocrine pancreas. The present study was performed to furt...

    Authors: N Ewald, A Raspe, C Kaufmann, RG Bretzel, HU Kloer and PD Hardt

    Citation: European Journal of Medical Research 2009 14:118

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  33. Content type: Research

    Endothelial progenitor cells (EPC) which are characterised by the simulateous expression of CD34, CD133 and vascular endothelial growth receptor 2 (VEGF 2) are involved in the pathophysiology of congestive hea...

    Authors: M Fritzenwanger, F Lorenz, C Jung, M Fabris, H Thude, D Barz and HR Figulla

    Citation: European Journal of Medical Research 2009 14:113

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  34. Content type: Research

    The insulin-like and vasodilatatory polypeptide relaxin (RLX), formerly known as a pregnancy hormone, has gained interest as a potential humoral mediator in human heart failure. Controversy exists about the re...

    Authors: M Heringlake, T Kox, J Poeling, S Klaus, T Hanke, N Franz, F Eberhardt, H Heinze, FP Armbruster and L Bahlmann

    Citation: European Journal of Medical Research 2009 14:106

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  35. Content type: Review

    Neurofibromatosis (NF) is one of the most common genetic disorders. Inherited in an autosomal dominant fashion, this phacomatosis is classified into two genetically distinct subtypes characterized by multiple ...

    Authors: PA Gerber, AS Antal, NJ Neumann, B Homey, C Matuschek, M Peiper, W Budach and E Bölke

    Citation: European Journal of Medical Research 2009 14:102

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  36. Content type: Review

    Stereotactic radiosurgery is related to the history of "radiotherapy" and "stereotactic neurosurgery". The concepts for neurosurgeons and radiooncologists have been changed during the last decade and have also...

    Authors: J Vesper, E Bölke, C Wille, PA Gerber, C Matuschek, M Peiper, HJ Steiger, W Budach and G Lammering

    Citation: European Journal of Medical Research 2009 14:93

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  37. Content type: Research

    The aim of the present roentgenographic in vitro study was to determine the initial straight length from the cemento-enamel junction (CEJ) to the appearance of a root canal curvature in human mandibular premol...

    Authors: B Willershausen, A Kasaj, B Röhrig and B Briseño

    Citation: European Journal of Medical Research 2009 14:85

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  38. Content type: Research

    Gene silencing associated with aberrant methylation of promoter region CpG islands is an acquired epigenetic alteration that serves as an alternative to genetic defects in the inactivation of tumor suppressor ...

    Authors: DM Kordi Tamandani, RC Sobti, M Shekari and A Huria

    Citation: European Journal of Medical Research 2009 14:71

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  39. Content type: Research

    Disturbances in wound healing in patients with hyperglycaemic blood sugar values are a common clinical problem. Recent studies identified PPARα-ligands as potential skin therapeutic agents. The aim of this stu...

    Authors: S Valentin, J Rudolph, O Goertz, N Botteck, S Langer and S Schneider

    Citation: European Journal of Medical Research 2009 14:65

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  40. Content type: Research

    Alterations of bone metabolism have been observed in numerous studies of HIV-infected patients. Sex steroids are known to profoundly influence bone mass and bone turnover. Hypogonadism is common in HIV-infecti...

    Authors: J Teichmann, U Lange, T Discher, J Lohmeyer, H Stracke and RG Bretzel

    Citation: European Journal of Medical Research 2009 14:59

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  41. Content type: Research

    Activation of the endothelin (ET) system promotes inflammation and fibrosis in various tissues including the kidney. Male ET-1 transgenic mice are characterized by chronic kidney inflammation and renal scarrin...

    Authors: P Kalk, C Thöne-Reineke, A Schwarz, M Godes, C Bauer, T Pfab and B Hocher

    Citation: European Journal of Medical Research 2009 14:55

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  42. Content type: Review

    Multiple myeloma (MM) is a malignancy with excessive production of monoclonal proteins. At disease presentation 30% of MM patients have significant renal impairment which may progress to renal failure requirin...

    Authors: L Kleeberg, S Morgera, C Jakob, B Hocher, M Schneider, H Peters, S Rötzer, C Müller, M Kaiser, C Fleissner, U Heider, H-H Neumayer and O Sezer

    Citation: European Journal of Medical Research 2009 14:47

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