Serum heparan sulfate levels are elevated in endotoxemia

Table 2 Pulmonary Gas Exchange and Hemodynamics

		Time Point of Measurement
	Baseline	3 h after Endotoxin	6 h after Endotoxin
PaO2, [mmHg]
Endotoxin*	572.2 ± 36.1	342.1 ± 113.5#	225.2 ± 157.7#
Control	603.1 ± 42,2	610.4 ± 48.6	628.2 ± 41.2
PaCO2 [mmHg]
Endotoxin*	34.4 ± 7.8	48.1 ± 7.4#	62.1 ± 18.5#
Control	30.5 ± 5.6	28.0 ± 5.1	28.7 ± 5.8
Minute ventilation [ml/kg.min]
Endotoxin	223.1 ± 43.8	244.9 ± 30.8	234.9 ± 57.9
Control	224.9 ± 50.5	219.4 ± 41.6	221.0 ± 49.3
Peak airway pressure [mbar]
Endotoxin*	26.4 ± 3.3	37.6 ± 3.9	53.6 ± 10.7#
Control*	29.4 ± 2.4	32.0 ± 2.8	36.9 ± 5.2
Norepinephrine requirements [mg/h]
Endotoxin	0.15 ± 0.09#	0.05 ± 0.04	0.15 ± 0.12#
Control	0.0	0.0	0.0
MAP [mmHg]
Endotoxin	72.3 ± 7.3	67.0 ± 9.2	67.6 ± 11.3
Control	90.1 ± 12.2	82.1 ± 9.6	72.5 ± 8.4
Heart Rate [min^-1]
Endotoxin*	86 ± 17	110 ± 17	124 ± 20#
Control*	90 ± 12	82 ± 9	78 ± 13
LVEDP [mmHg]
Endotoxin	9.0 ± 1.2	9.1 ± 1.3	9.0 ± 2.1
Control	8.4 ± 0.2	8.3 ± 0.7	8.3 ± 0.4

* Significant changes over time within a group (p < 0.05). # Significant differences between groups at the referring time points of measurement (p < 0.05).
PaO₂: Arterial oxygen tension; PaCO₂: Arterial carbondioxid tension; MAP: Mean arterial blood pressure; LVEDP: Left ventricular enddiastolic blood pressure

ISSN: 2047-783X