Table 1 Studies in a chronological order focusing on adherence to prescribed oral medication in adult HD patients
Study, year | Included patients | Medication type | % Non-adherent | Nonadherence definition/assessment | Results |
|---|---|---|---|---|---|
Wenerowicz, 1978 [15] | 19 | PB | 60 | P > 4.5 mg/dl PSR (questionnaire) | Patients with internal locus of control1 orientation showed higher compliance than with external locus |
Cummings, 1982 [51] | 116 | PB | 70 | P > 5.5 mg/dl PSR (interview) | Situational factors and psychosocial variables major contributors to adherence |
Betts, 1988 [52] | 46 | PB | 74 | P > 5 mg/dl PSR (questionnaire) | Length of time on HD, age, educational level and response to illness not significantly related to adherence |
Weed-Collins, 1989 [22] | 30 | PB | 64 | P > 5.5 mg/dl PSR (questionnaire) | Perceived barriers ("forgetting" and "being away from home") most significant predictors of compliance, women significantly more compliant |
Blanchard, 1990 [53] | 40 | PB, CAS, Vits | 28 | PSR (questionnaire) | Majority of HD patients knew dosing schedules but knowledge about drug treatment was grossly deficient |
Bame, 1993 [23] | 1230 | PB, AHT, CAS | 50 | P > 6.0 mg/dl | Prevalence of noncompliance consistent with previous studies; older age and higher income associated with compliance |
Kaplan, 1994 [7] | 30 | PB, AHT | 67 | PSR (questionnaire) Reporting missing a dose | Drug selection and medication compliance contained greatest number of potential problems |
Cleary, 1995 [18] | 51 | AHT, PB, CAS, Vits | 61 | P > 4.5 mg/dl (interview) | Patients with long-term HD more compliant with AHT and CAS than with PB |
Lin, 1997 [54] | 86 | PB, CAS | 24 - 61 | P > 4.59 mg/dl, PSR, nurses' assessment | Multidimensional Health Locus of Control (MHLC) scale had only slight influence on measures of compliance |
Curtin, 1997 [17] | 135 | AHT, PB | 42 - 80 | MEMS | Patients ≤ 65 yrs made more dosing errors with AHT and missed taking PB on more days than patients > 65 yrs |
Leggat, 1998 [16] | 6251 | PB | 22 | P > 7.5 mg/dl | Younger patients and smokers with higher rates of noncompliance; blacks significantly less noncompliant than whites |
Curtin, 1999 [6] | 135 | AHT, PB | 73 | PSR, pill count, MEMS | African-Americans with higher rates of noncompliance |
Caraballo Nazario, 2001 [19] | 53 | AHT, PB, CAS | 75 | PSR, Reporting missing a dose (structured interview) | Significant association between compliance and educational level |
Horne, 2001 [55] | 47 | AHT, PB, CAS | 57 | PSR, Reporting missing a dose (self report) | Nonadherence correlated with concerns about potential adverse effects of medication |
Tomasello, 2004 [56] | 129 | PB | 38-51 | PSR (taking < 80% of medication), P > 5.5 mg/dl | Compliance did not account for the large difference in prescribed pill burden |
Rahman, 2004 [57] | 205 | AHT | 23 | PSR, Reporting missing a dose | Good adherence to AHT therapy |
Holley, 2006 [20] | 39 | AHT, PB | 21 | PSR, Reporting missing a dose (structured interview) | Inadequate prescription coverage, lack of transportation, and medication cost contribute to noncompliance |
Lindberg, 2007 [58] | 144 | AHT, PB, CAS, Vits | 80 | Discrepancy between self-report and medication list | Deviation between consumption and prescription in chronic HD patients |
Hirth, 2008 [21] | 5478 | AHT, PB, CAS | 3 *-29 ** | Reporting costrelated nonadherence (questionnaire) | Cost-related nonadherence varies across countries, substantial international variation |