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Table 2 Positions and frequencies of selected C-terminal mutations in sequences of viral isolate from HIV-1 infected patients

From: Mutations in the C-terminal region of the HIV-1 reverse transcriptase and their correlation with drug resistance associated mutations and antiviral treatment

   

therapy-naïve patients

pre-treated patients

 

HXB2- sequence

substitutions in total (%)

Substitutions

Total (%)

Substitutions

Total (%)

369

T

5 (8%)

P

1 (4%)

AIV

4 (10%)

395

K

9 (13%)

R

2 (8%)

R

7 (15%)

399

E

15 (21%)

D

2 (8%)

DGK

13 (29%)

520

Q

4 (5%)

None

0

EHK

4 (8%)

524

Q

10 (14%)

E

2 (8%)

EK

8 (16%)

554

A

37 (51%)

NST

10 (40%)

NST

26 (54%)

  1. Amino acids in bold are only present in sequences derived from pre-treated patients (*).
  2. Only the Positions and frequencies of C-terminal mutations that are either statistical associated or showing the tendency to be associated with antiretroviral treatment are shown