Table 1
From: GNAS1 T393C polymorphism and disease progression in patients with malignant melanoma
All | TT | TC | CC | P | |
|---|---|---|---|---|---|
N (%) | 328 | 69 (21.0) | 149 (45.4) | 110 (33.5) | |
Gender (m/f) | 167/161 | 30/39 | 86/63 | 51/59 | 0.074 |
Mean age at diagnosis | 54.2 | 55.0 | 54.4 | 53.4 | 0.517 |
UICC Category. | |||||
I | 202 (61.6) | 45 (22.3) | 85 (42.1) | 72 (35.6) | |
II | 72 (22.0) | 13 (18.1) | 34 (47.2) | 25 (34.7) | |
III | 47 (14.3) | 9 (19.1) | 30 (63.8) | 8 (17.0) | |
IV | 7 (2.1) | 2 (28.6) | 0 (0) | 5 (71.4) | 0.683 |
Type | |||||
SSM | 153 | 31 | 71 | 51 | |
NM | 38 | 8 | 16 | 14 | |
LMM | 34 | 9 | 14 | 11 | |
ALM | 30 | 7 | 16 | 7 | |
UCM | 73 | 14 | 32 | 27 | |
Tumor thickness (mm) | |||||
<0,75 | 191 (58.2) | 40 (20.9) | 80 (41.9) | 71 (37.2) | |
0,75-1,5 | 55 (16.8) | 14 (25.5) | 27 (49.1) | 14 (25.5) | |
1,5- 4 | 58 (17.7) | 8 (13.8) | 31 (53.4) | 19 (32.8) | |
> 4 | 24 (7.3) | 7 (29.2) | 11 (45.8) | 6 (25.0) | 0.385 |
Clark level | |||||
I | 51 (15.5) | 10 (19.6) | 22 (43.1) | 19 (37.3) | |
II | 40 (12.2) | 10 (25.0) | 15 (37.5) | 15 (37.5) | |
III | 114 (34.8) | 24 (21.1) | 50 (43.9) | 40 (35.1) | |
IV | 92 (28.0) | 20 (21.7) | 45 (48.9) | 27 (29.1) | |
V | 10 (3.0) | 2 (20.0) | 6 (60.0) | 2 (20.0) | 0.333 |
Node | |||||
0 | 305 (93.0) | 66 (21.6) | 135 (44.3) | 104 (34.1) | |
1 | 13 (4.0) | 3 (23.1) | 6 (46.2) | 4 (30.8) | |
2 | 10 (3.0) | 0 (0) | 8 (80.0) | 2 (20.0) | 0.865 |
Distant metastasis | |||||
No | 321 (97.9) | 67 (20.9) | 149 (46.4) | 105 (32.7) | |
Yes | 7 (2.1) | 2 (28.6) | 0 (0,0) | 5 (71.4) | 0.266 |