Table 2 Expression of Notch signaling molecules in odontogenic neoplasms as examined by ISH and IHC
Studies | Notch1 | Notch2 | Notch3 | Notch4 | Jagged1 | Jagged2 | Delta1 |
|---|---|---|---|---|---|---|---|
Ameloblastoma (n = 22) [14] | Â | Â | Â | Â | Â | Â | Â |
   Peripheral cells | - | + | - | NA | -/+ | NA | -/+ |
   Central cells | +/++ | ++ | +/++ | NA | + | NA | +/++ |
   Keratinizing cells | - | - | - | NA | - | NA | - |
   Granular cells | - | - | - | NA | - | NA | - |
   Stromal cells | +/++ | +/++ | +/++ | NA | +/++ | NA | +/++ |
Ameloblastic carcinoma (n = 1) [16] | Â | Â | Â | Â | Â | Â | Â |
   Peripheral cells | + | NA | NA | NA | NA | NA | NA |
   Central cells | +++ | NA | NA | NA | NA | NA | NA |
Ameloblastic fibroma (n = 1) [17] | Â | Â | Â | Â | Â | Â | Â |
   Peripheral cells | + | NA | NA | NA | NA | NA | NA |
   Central cells | +++ | NA | NA | NA | NA | NA | NA |
   Dental papilla-like cells | +++ | NA | NA | NA | NA | NA | NA |
Odontogenic myxoma (n = 1) [17] | Â | Â | Â | Â | Â | Â | Â |
   Dental papilla-like cells | - | NA | NA | NA | NA | NA | NA |
Squamous odontogenic tumor (n = 1)* | Â | Â | Â | Â | Â | Â | Â |
   Peripheral cells | ++ | - | + | +++ | +/++ | - | -/+ |
   Central cells | ++ | - | + | +++ | +/++ | - | -/+ |
   Keratinizing cells | ++ | - | + | +++ | +/++ | - | -/+ |
   Cystic degeneration | ++ | - | + | +++ | +/++ | - | -/+ |
   Clear cells | ++ | - | + | +++ | +/++ | - | -/+ |
   Dystrophic calcifications | ++ | - | + | +++ | +/++ | - | -/+ |