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Table 3 Cancer incidence. standardized incidence ratios (SIR) and corresponding 95% confidence intervals by primary site and sex

From: Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence

Sex

Malignancy

Observed Events Bonn cohort 1996 - 2008

Expected Events*

SIR (95% CI)

p-Value

  

n

n

  

Male

Kaposi

41

< 0.1

5682.6 (4076.3 - 7555.2)

< 0.001

 

NHL

28

0.8

35.0 (23.3 - 49.2)

< 0.001

 

Hodgkin

8

0.2

38.7 (16.5 - 70.2)

< 0.001

 

Liver

7

0.4

18.2 (7.2 - 34.1)

< 0.001

 

Anal

6

0.1

87.8 (31.6 - 172.1)

< 0.001

 

Lung

5

3.3

1.5 (0.5 - 3.1)

0.509

 

Oropharyngeal

3

2.4

1.1 (0.2 - 2.7)

0.905

 

Colorectal

3

2.7

1.1 (0.2 - 2.8)

0.920

 

CUP

2

0.6

3.5 (0.3 - 10.1)

0.215

 

Melanoma

1

2.1

0.5 (0.0 - 1.9)

0.682

 

Thyroid

1

0.2

5.2 (0.0 - 20.6)

0.478

 

Renal

1

0.9

1.1 (0.0 - 4.3)

0.660

 

All cancer

106

24.1

4.4 (3.6 - 5.3)

< 0.001

 

Infection-related

89

1.2

75.5 (60.6 - 92.0)

< 0.001

 

Non-Infect. related

17

21.6

0.8 (0.5 - 1.2)

0.374

Female

Cervix

6

1.5

4.0 (1.5 - 7.9)

0.001

 

Kaposi

2

< 0.1

277.2 (26.1 - 794.5)

< 0.001

 

NHL

2

0.1

18.2 (1.7 - 52.1)

< 0.001

 

Anal

2

< 0.1

115.2 (10.9 - 330.1)

< 0.001

 

Breast

1

1.5

0.7 (0.0 - 2.6)

1.000

 

Endometrium

1

0.2

5.3 (0.0 - 20.9)

0.472

 

Thyroid

1

0.1

8.0 (0.0 - 31.4)

0.289

 

All cancer

15

6.0

2.5 (1.4 - 3.9)

< 0.001

 

Infection-related

12

1.6

7.3 (3.8 - 12.0)

< 0.001

 

Non-Infect. Related

3

4.1

0.7 (0.1 - 1.8)

0.780

  1. * Expected events within the Bonn cohort based on the age-specific rates of the Saarland population (11).