Skip to main content

Table 3 Cancer incidence. standardized incidence ratios (SIR) and corresponding 95% confidence intervals by primary site and sex

From: Cancer risk in HIV-infected individuals on HAART is largely attributed to oncogenic infections and state of immunocompetence

Sex Malignancy Observed Events Bonn cohort 1996 - 2008 Expected Events* SIR (95% CI) p-Value
   n n   
Male Kaposi 41 < 0.1 5682.6 (4076.3 - 7555.2) < 0.001
  NHL 28 0.8 35.0 (23.3 - 49.2) < 0.001
  Hodgkin 8 0.2 38.7 (16.5 - 70.2) < 0.001
  Liver 7 0.4 18.2 (7.2 - 34.1) < 0.001
  Anal 6 0.1 87.8 (31.6 - 172.1) < 0.001
  Lung 5 3.3 1.5 (0.5 - 3.1) 0.509
  Oropharyngeal 3 2.4 1.1 (0.2 - 2.7) 0.905
  Colorectal 3 2.7 1.1 (0.2 - 2.8) 0.920
  CUP 2 0.6 3.5 (0.3 - 10.1) 0.215
  Melanoma 1 2.1 0.5 (0.0 - 1.9) 0.682
  Thyroid 1 0.2 5.2 (0.0 - 20.6) 0.478
  Renal 1 0.9 1.1 (0.0 - 4.3) 0.660
  All cancer 106 24.1 4.4 (3.6 - 5.3) < 0.001
  Infection-related 89 1.2 75.5 (60.6 - 92.0) < 0.001
  Non-Infect. related 17 21.6 0.8 (0.5 - 1.2) 0.374
Female Cervix 6 1.5 4.0 (1.5 - 7.9) 0.001
  Kaposi 2 < 0.1 277.2 (26.1 - 794.5) < 0.001
  NHL 2 0.1 18.2 (1.7 - 52.1) < 0.001
  Anal 2 < 0.1 115.2 (10.9 - 330.1) < 0.001
  Breast 1 1.5 0.7 (0.0 - 2.6) 1.000
  Endometrium 1 0.2 5.3 (0.0 - 20.9) 0.472
  Thyroid 1 0.1 8.0 (0.0 - 31.4) 0.289
  All cancer 15 6.0 2.5 (1.4 - 3.9) < 0.001
  Infection-related 12 1.6 7.3 (3.8 - 12.0) < 0.001
  Non-Infect. Related 3 4.1 0.7 (0.1 - 1.8) 0.780
  1. * Expected events within the Bonn cohort based on the age-specific rates of the Saarland population (11).