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Table 1 Pharmacokinetics of echinocandins for the treatment of Candida infections

From: Pharmacology and metabolism of anidulafungin, caspofungin and micafungin in the treatment of invasive candidosis - review of the literature

Parameter anidulafungin caspofungin micafungin
Mode of administration IV IV IV
Dose linearity + + +
Oral availability [%] n/a n/a n/a
Plasma protein binding [%] 99 97 99
Volume of distribution [L] 30-50 n/a 18
Elimination half-life [h] 24 9-11 10-17
Route of elimination D, D/M M
  F U > F F > U
  1. E = excretion unchanged; M = drug is metabolised; D = drug is degraded; U = urine; F = faeces