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Table 1 Baseline data and histological findings of 118 patients with histologically proven non-alcoholic fatty liver disease (NAFLD) and 18 lean controls. Data is presented as mean (SD)

From: The non-invasive 13C-methionine breath test detects hepatic mitochondrial dysfunction as a marker of disease activity in non-alcoholic steatohepatitis

Variable Lean Controls
n = 18
Simple Steatosis
n = 11
Borderline NASH
n = 47
Definite NASH
n = 53
NASH Cirrhosis
n = 7
Gender      
    Male, n 11 7 31 36 5
    Female, n 7 4 16 17 2
Age, yr 44.0 (10) 51.0 (12) 50.5 (12) 49.5 (12) 59.0 (6)
BMI, kg/m 2 24.4 (2.3) 24.6 (4.6) 27.4 (7.2) 30.3 (6.3)a 31.1 (4.6)a
Serum ALT, U/l 26 (8) 41 (12) 67 (40)a 94 (64)aa 64 (30)a
Cholesterol, mg/dl 172 (12) 243 (39) 235 (47) 216 (49) 189 (48)
Triglycerides, mg/dl 136 (17) 142 (75) 239 (1172) 211 (127) 185 (118)
Impaired glucose tolerance, n 0 0 15 21 2
Diabetes mellitus Type 2, n 0 2 9 5 3
Fibrosis score, n      
    F 0 - 9 11 2 -
    F 1 - 1 29 28 -
    F 2 - 1 3 10 -
    F 3 - 0 4 13 -
  1. ap < 0.01 vs. simple steatosis and lean controls by Dunn's post hoc test
  2. Abbreviations: ALT: alanine amino-transferase; BMI: body mass index; n: number of patients