Skip to main content

Table 2 Mortality, weight, food and water intake, liver weight and histology in rats with D-galactosamine-induced acute liver failure with or without SLV338 treatment

From: Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure

  Con Con+SLV GalN GalN+SLV
N 9 9 19 22
Mortality (%) 0 0 42.9 37.1
Weight at injection of GalN (g) 304 ± 7 292 ± 3 300 ± 4 297 ± 3
Weight 48 h after GalN (g) 298 ± 8 298 ± 3 280 ± 6 283 ± 4
Food intake within 48 h after GalN (ml) 47 ± 0.2 49 ± 0.5* 20 ± 1.4*** 26 ± 2.0***#
Water intake within 48 h after GalN (ml) 69 ± 1.9 89 ± 2.8*** 55 ± 2.4** 65 ± 1.2*##
Liver weight (g) 10.5 ± 0.4 10.6 ± 0.2 9.5 ± 0.5 8.5 ± 0.4*
Liver necrosis score (0-3) 0.61 ± 0.3 0.22 ± 0.1 1.95 ± 0.2** 2.02 ± 0.2**
Liver inflammation score (0-3) 0 ± 0 0 ± 0 0.97 ± 0.2** 1.09 ± 0.2***
  1. Con, controls; SLV, SLV338; GalN, D-galactosamine.
  2. Data are means ± standard error of the mean.
  3. *p < 0.05, **p < 0.01, ***p < 0.001 vs. Con. #p < 0.05, ##p < 0.01 vs. GalN.