Table 2 Mortality, weight, food and water intake, liver weight and histology in rats with D-galactosamine-induced acute liver failure with or without SLV338 treatment
Con | Con+SLV | GalN | GalN+SLV | |
|---|---|---|---|---|
N | 9 | 9 | 19 | 22 |
Mortality (%) | 0 | 0 | 42.9 | 37.1 |
Weight at injection of GalN (g) | 304 ± 7 | 292 ± 3 | 300 ± 4 | 297 ± 3 |
Weight 48 h after GalN (g) | 298 ± 8 | 298 ± 3 | 280 ± 6 | 283 ± 4 |
Food intake within 48 h after GalN (ml) | 47 ± 0.2 | 49 ± 0.5* | 20 ± 1.4*** | 26 ± 2.0***# |
Water intake within 48 h after GalN (ml) | 69 ± 1.9 | 89 ± 2.8*** | 55 ± 2.4** | 65 ± 1.2*## |
Liver weight (g) | 10.5 ± 0.4 | 10.6 ± 0.2 | 9.5 ± 0.5 | 8.5 ± 0.4* |
Liver necrosis score (0-3) | 0.61 ± 0.3 | 0.22 ± 0.1 | 1.95 ± 0.2** | 2.02 ± 0.2** |
Liver inflammation score (0-3) | 0 ± 0 | 0 ± 0 | 0.97 ± 0.2** | 1.09 ± 0.2*** |