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Table 4 Big endothelin-1 and endothelin-1 tissue concentrations in rats with D-galactosamine-induced acute liver failure with or without SLV338 treatment

From: Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure

  Con Con+SLV GalN GalN+SLV
N 9 9 19 22
Liver     
   Big Endothelin-1 (pg/100mg protein) 29 ± 9 25 ± 2 38 ± 4 21 ± 4#
   Endothelin-1 (pg/100mg protein) 40 ± 16 45 ± 13 19 ± 3 25 ± 6
Kidney     
   Big Endothelin-1 (pg/100mg protein) 18 ± 3 16 ± 4 18 ± 4 13 ± 2*
   Endothelin-1 (pg/100mg protein) 122 ± 22 67 ± 19 59 ± 11* 43 ± 6**
  1. Con, controls; SLV, SLV338; GalN, D-galactosamine.
  2. Data are means ± standard error of the mean.
  3. *p < 0.05, **p < 0.01 vs. Con. #p < 0.01 vs. GalN.