Table 4 Big endothelin-1 and endothelin-1 tissue concentrations in rats with D-galactosamine-induced acute liver failure with or without SLV338 treatment
Con | Con+SLV | GalN | GalN+SLV | |
|---|---|---|---|---|
N | 9 | 9 | 19 | 22 |
Liver | ||||
Big Endothelin-1 (pg/100mg protein) | 29 ± 9 | 25 ± 2 | 38 ± 4 | 21 ± 4# |
Endothelin-1 (pg/100mg protein) | 40 ± 16 | 45 ± 13 | 19 ± 3 | 25 ± 6 |
Kidney | ||||
Big Endothelin-1 (pg/100mg protein) | 18 ± 3 | 16 ± 4 | 18 ± 4 | 13 ± 2* |
Endothelin-1 (pg/100mg protein) | 122 ± 22 | 67 ± 19 | 59 ± 11* | 43 ± 6** |