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Table 2 2a. General features, ASFP and renal funcdon (Kidney), blood acid-base status (Blood), and urine components (Urine) of the TRCU patients as found associated with the strata Low (L) and High (H) of 5 markers of OM; for abbreviations and medians of markers coded A - E see footnotes of Table 1. Data are mean (SE); [ ]: number of observations. For other abbreviations and further informations see footnotes and text.

From: Idiopathic recurrent calcium urolithiasis (IRCU): pathophysiology evaluated in light of oxidative metabolism, without and with variation of several biomarkers in fasting urine and plasma - a comparison of stone-free and -bearing male patients, emphasizing mineral, acid-base, blood pressure and protein status

   

General features

   

Kidney

 

Blood

 

Urine

     

Code

Markers

Strata

N*

Age

BMI

kg/(m) 2

Systolic BP

mm Hg

Diastolic BP

mm Hg

ASFP

score

C-Cr**

ml/min

HCO 3

mM-l"'

pH

pH

Volume

ml

Na+K

mM DG

SS-UA

SS-CaOx

DG

SS-HAP

DG

A

P-UA

               
 

   L 307(4)

78

43(1)

26.0(0.3)

126(2)[65]

81(1)[65]

33(3)

112(3)

23.6(0.2)

7.40(0.0)

6.23 (0.09)

246(18)

21(0.8)

4.5(0.2)[74]

0.9(0.1)[74]

3.6(0.3)[74]

 

   H 408(6)

76

40(1)

26.6(0.3)

128(2)[65]

83(1)[65]

41(5)

110(2)

23.3(0.3)

7.40(0.0)

6.02(0.09)

195(15)

20(1.1)

5.3(0.2)171]

1.1(0.1)[71]

2.2(0.4)[71]

 

   p <0.001

 

0.11

0.07

0.34

0.22

0.09d

0.23

0.18

0.37

0.04

0.02

0.08

0.002

0.2

0.003

B

U-MDA

               
 

   L 89(2)

77

40(1)

26.2(0.3)

124(2)[65]

80(1)[65]

37(5)

112(2)

23.1(0.3)

7.40(0.0)

6.05(0.09)

162(13)

18(0.7)

5.2(0.2)

1.3(0.1)

3.1(0.4)

 

   H 173(5)

77

43(1)

26.4(0.3)

130(3)165]

85(2)[65]

37(3)

110(2)

23.9(0.2)

7.41(0.0)

6.20(0.09)

280(18)

23(1.1)

4.5(0.2)

0.6(0.1)

2.7(0.3)

 

   p <0.001

 

0.03

0.26

0.03

0.01

0.32d

0.23

0.02

0.005

0.13

<0.001

0.001

0.003

< 0.001

0.19

C

U-MDA/P-UA

               
 

   I. 244(7)

77

40(1)

26.3(0.3)

124(2)[65]

81(1)[65]

36(5)

112(2)

23.1(0.3)

7.40(0.0)

6.04(0.09)

151(12)

18(0.7)

5.2(0.2)[74]

1.4(0.])[74]

3.1(0.4)[74]

 

   H 519(18)

77

43(1)

26.4(0.4)

130(2)[65]

84(1)[65]

37(3)

110(2)

23.8(0.2)

7.41(0.0)

6.21(0.08)

291(18)

23(1.2)

4.5(0.2)[71]

0.6(0.1)[74]

2.7(0.3)[71]

 

   P <0.001

 

0.11

0.32

0.06

0.05

0.31d

0.29

0.02

0.01

0.08

< 0.001

0.001

<0.001

0.001

0.19

D

U-NIT

               
 

   L 85(3)

59

43(1)

26.4(0.3)

126(3)[52]

81(2)[52]

38(5)

109(3)

23.0(0.3)

7.40(0.0)

6.13(0.10)

184(16)

19(1.0)

5.0(0.2)[52]

1.3(0.2)[52]

3.5(0.4)[52]

 

   H 184(11)

58

42(1)

26.5(0.3)

127(3)[48]

83(2)[48]

35(4)

115(3)

23.4(0.2)

7.40(0.0)

6.20(0.10)

278(22)

22(1.3)

4.5(0.2)[57]

0.7(0.2)[571

2.3(0.4)[57]

 

   P <0.001

 

0, 43

0.41

,0.39

0.26

0.31d

0.09

0.19

0.41

0.33

< 0.001

0.04

0.04

0.004

0.02

E

U-NIT/P-UA

               
 

   L 247(10)

59

41(1)

26.4(0.3)

126(3)L54J

81(2)[54]

36(5)

111(3)

23.1(0.1)

7.40(0.0)

6.11(0.109)

184(16)

19(0.9)

5.0(0.2)[53]

1.2(0.2)[53]

3.2(0.4)[53]

 

   H 533(35)

58

44(1)

26.5(0.4)

127(3)[46]

83(2)[46]

37(5)

113(3)

23.3(0.2)

7.40(0.0)

6.23(0.10)

278(22)

21(1.3)

4.4(0.2)[56]

0.7(0.2)[56]

2.5(0.4)[56]

 

   p < 0.001

 

0.13

0.42

0.42

0.22

0.34d

0.34

0.37

0.49

0.20

< 0.001

0.11

0.03

0.008

0.10

2b. Additional data (urine, plasma, urine/plasma) from the same IRCU padcnts as organized in Table 2a. Data are mean (SE). For further informations see footnotes, Table 2a and text.

  

Urine

       

Plasma

   

Urine (U)/Plasma (P)

  

Code

Markers

Strata

N-AIb-P mg

Ca mM

Pi mM

Ca/Pi

mM/mM

(Ca/Pi)/Cit 1/mM

(Ca/Pi)/Mg

1/mM

N-Alb-P 1 -1

N-Alb-P g 1 -1

PTH

pg ml -1

Ca

mM-1 -1

Pi

mM-1 -1

Ca/Pi

mM/mM

U M /P M *

U NP /P NP **

 

A

P-UA

               
 

L

8.4(2.4)

0, 35(0, 02)

1, 3(0.07)

0, 40(0, 06)

0.32(0.04)

0, 32(0, 03)

40(8)[75]

23.1(0.5)

26(1)

2.34(0.01)

1.01(0.02)

2, 45(0.04)

0.16(0.02)

1.68(0.3)[75]

 
 

   H

4, 0(0.6)

0, 29(0.02)

1, 2(0.09)

0.38(0.05)

0.32(0.06)

0, 32(0.06)

28(3)[73]

24.5(0.5)

28(2)

2.34(0, 01)

1.01(0.02)

2.45(0.05)

0.16(0, 02)

1.19(0.1)173)

 
 

   P

0.005 d

0.01

0, 17

0, 37

0.21

0, 20

0.16

0.03

0, 13

0, 29

0, 46

0, 50

0.39

0.08d

 

B

U-MDA

               
 

   L

3.5(0.6)

0.31(0.02)

1.18(0.07)

0.40(0.05)

0, 26(0.03)

0, 24(0.03)

32(3)[75]

23.4(05)

29(2)

2.35(0.01)

1.00(0.02)

2.49(0.05)

0.16(0.02)

1.42(0.1)[74]

 
 

   H

8.9(2.4)

0, 33(0.02)

1.31(008)

0.39(0.06)

0.33(0.07)

040(0.06)

36(8)[73]

24.2(0.5)

25(1)

2, 33(0, 01)

1, 02(0.02)

2.42(0.04)

0.16(0.02)

1, 45(0 3)[74]

 
 

   p

0.001d

0.23

0.11

0.42

0.03d

0.001d

0.14

0.14

0.04

0.21

0.16

0.13

0.49

0.09d

 

C

U-MDA/P-UA

               
 

   L

3.5(0.5)

0.30(0.02)

1.13(0.08)

0.40(0.05)

0.26(0.09)

0.25(0.03)

32(3)[75]

23.7(0.5)

28(1)

2.35(0.01)

1.00(0.02)

2.49(0, 04)

0.16(0.02)

1.41(0, 1)[74]

 
 

   H

8.9(2.4)

0.35(0.02)

1.35(0.08)

0.39(0.06)

0.39(0.04)

039(0.06)

36(8)[731

23.8(0.5)

26(1)

2, 33(0.01)

1.02(0, 02)

2.42(0.05)

0.16(0.02)

1.46(0.3)[74]

 
 

   p

0.001 d

0.03

0.02

0.42

0.005

0.00 l d

 

0.43

0.12

0.14

0.19

0.14

0.49

0.16d

 

D

U-Nit

               
 

   L

68(2.8)

0.32(0.03)

1.21(0.09)

0.39(0.05)

0.24(0.03)

0.28(0.03)

39(8)[57]

23.9(0 7)

30(2)

235(0.02)

0.97(0.02)

2.54(0.05)

0.15(0.02)

1.65(0.3)[57]

 
 

   H

6.7(1.8)

0.34(0.02)

1.25(0.09)

0.39(0.06)

0.43(0.09)

0.39(0.07)

30(7)[56]

23.0(0.6)

26(2)

2 33(0.01)

1.05(0.02)

2.35(0.05)

0.17(0.02)

1.31(0.2)[56]

 
 

   p

0.1011

0.32

0, 37

48

0.02 d

007d

009d

0.18

0.05

0.12

0.005

0.004

0.32

0.14d

 

E

U-Nit/P-UA

               
 

   L

6.2(2.8)

0.32(0.03)

1.12(0.09)

0.47(0.06)

0.33(0.07)

0.36(0.07)

37(8)[57]

23.9(0, 7)

30(2)

236(0.02)

0.99(0.02)

2.53(0.05)

0.18(0.02)

59(0.3)[56]

 
 

   H

7, 4(1.8)

0.34(0.02)

1.34(6.09)

0.31(0.07)

0.34(0.06)

0.31(0 04)

33(7)[56]

22.9(0.6)

26(1)

2.32(0.01)

1.04(0.02)

2.36(0.05)

0.14(0.01)

1.37(0.2)[57J

 
 

   p

0.04 d

0.3

0.04

0.01

0.19

0.5

0.24

0.14

0.06

0.005

0.04

0.01

0.04

0.32d

 
  1. *: Number of patients in strata; **: Creatinine clearance; p (in bold): level of significance ≤ 0.05; d: based on logio data; shaded areas: parameters supposedly participating in IRCU pathogenesis.
  2. d: based on log10 data: *: denotes Ca/Pi in urine divided by Ca/Pi in plasma: **: denotes 103 × N-Alb-P in urine divided by N-Alb-P in plasma; dashed position (UM/PM): end-point of Ca and Pi metabolism, as modified by change of parameters given as shaded positions (codes E, D, B).