Figure 2

Effects of PARP-l inhibition on atherosclerotic plaques in Apoe^-/- mice. Morphomctric quantification of fractional stenosis [%] (A) and maximum stenosis [%] (A) and maximum stenosis [%] (B) of early atherosclerotic lesions were compared between INO-1001 treated (n = 15) and control mice (n = 15). Results are shown as box plots displaying medians and 25th and 75th percentiles as boxes and 10th and 90th percentiles as whiskers. Representative Oil Red O immunohistostainings from aortic root of control (C) and INO-1001 treated (D) mice are shown.