Figure 2
From: GDF-15 protects from macrophage accumulation in a mousemodel of advanced atherosclerosis
Macrophage staining of the aortic root of a LDLr−/−mouse, transplanted with bone marrow from a GDF-15−/−donor (A) demonstrated an enhanced macrophage accumulation (arrows) within the atherosclerotic lesion compared to a control animal (B). Staining for ICAM-1 furthermore showed an increased expression (arrows) in animals transplanted with GDF-15 deficient bone marrow (C) in contrast to controls (D). Pictures demonstrate a colocalization of macrophages and ICAM-1.